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Pharmacology know why, know-what,know-how

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Pharmacology know why, know-what,know-how

  1. 1. CONGRATULATIONS…….. YOU ALL HAVE FAILED
  2. 2. YOU ALL HAVE FAILED TO MISS SUCCESS….!
  3. 3. PHARMACOLOGY- KNOW-WHAT, KNOW-WHY, KNOW Dr. V.SATHYA NARAYANAN M.B.B.S., M.D., PROFESSOR OF PHARMACOLOGY
  4. 4. PHARMACOLOGY TEXT BOOKS
  5. 5. PHARMACOLOGY TEXT BOOKS
  6. 6. WHAT IS PHARMACOLOGY ? ∗ SCIENCE OF DRUGS AND THEIR ∗ INTERACTIONS ON LIVING SYSTEM
  7. 7. WHAT IS A DRUG ? ∗ ANY SUBSTANCE USEFUL FOR ∗ CURING THE DISEASE ∗ PREVENTING THE DISEASE
  8. 8. WHAT A DRUG ALSO CAN DO ? ∗ HARM- From minor to serious ∗ Sometimes even FATAL
  9. 9. WHAT A DRUG CANNOT DO? ∗ Magical cure for every disease…
  10. 10. WHY PHARMACOLOGY ?
  11. 11. Increased intake of a prescribed and unPrescribed medicine
  12. 12. Prescribing drugs is the deciding factor in patient cure
  13. 13. To choose drugs wisely
  14. 14. WHEN TO STUDY PHARMACOLOGY ?
  15. 15. KNOW-WHEN? ∗ NOW AND… ∗ EVERYDAY ∗ WITH BOOKS AND PATIENTS ∗ GUIDED BY EXPERTS
  16. 16. CONTINUOUS AND EVEN LIFELONG…. ∗ Should be continuous, life long
  17. 17. WHAT TO STUDY IN PHARMACOLOGY?
  18. 18. WHAT TO STUDY IN PHARMACOLOGY ? ∗ General pharmacology - Definitions - Routes of drug administration - Pharmacokinetics - Pharmacodynamics - Adverse drug reactions ∗ Systemic pharmacology - ANS, CVS, blood, autacoids related drugs, RS, CNS, GIT, Hormones, Chemotherapy
  19. 19. General pharmacological principles ∗
  20. 20. Definitions
  21. 21. Routes of drug administration
  22. 22. PHARMACOKINETICS ∗ What the body does to the drug.
  23. 23. Pharmacokinetics Is what the body does to the drug. ∗ Absorption ∗ Distribution ∗ Metabolism ∗ Elimination
  24. 24. PHARMACODYNAMICS ∗ What the drug does to the body. ∗
  25. 25. Pharmacodynamics Is what the drug does to the body. Interaction of drugs with cellular proteins, such as receptors or enzymes, to control changes in physiological function of particular organs. ∗ Drug-Receptor Interactions ∗ Binding ∗ Dose-Response ∗ Effect ∗ Signal Transduction ∗ Mechanism of action, Pathways
  26. 26. Endogenous compounds act on their Receptors Neurotransmitter Neuropeptides Hormones Ions http://www.morphonix.com/software/education/science/brain/game/specimens/neurotrans
  27. 27. Drug-Receptor Interactions ∗Drug-receptor interactions  signals to trigger a cascade of events. collection of many cellular responses serve to amplify the signal produce a final effect. ∗Effectors are thus the molecules that translate the drug- receptor interaction into changes in cellular activity. •  •+         EFFECT DRUG UG + RECEPTOR DRUG + RECEPTOR EFFECTOR EFFECTOR INTERACTION COMPLEX SYSTEM STIMULUS BINDING ACTIVATION TRANSDUCTION AMPLIFICATION RESPONSE SIGNALLING PATHWAY
  28. 28. Adverse drug reactions
  29. 29. Prevention is better than cure
  30. 30. Clinical pharmacology & drug development
  31. 31. SYSTEMIC PHARMACOLOGY
  32. 32. Systemic pharmacology ∗ ANS ∗ CVS ∗ BLOOD ∗ Autacoids ∗ RS ∗ CNS ∗ GIT ∗ Hormones ∗ Chemotherapy
  33. 33. KNOW-HOW
  34. 34. HOW TO STUDY PHARMACOLOGY ? ∗ Classification ∗ Pharmacological actions ∗ Mechanism of action ∗ Pharmacokinetics ∗ Adverse drug reactions ∗ Drug interactions ∗ Precautions ∗ Contraindications ∗ Indications (Therapeutic uses)
  35. 35. Classification
  36. 36. Pharmacological actions
  37. 37. Mechanism of action
  38. 38. Pharmacokinetics
  39. 39. Adverse drug reactions
  40. 40. Drug interactions
  41. 41. Precautions
  42. 42. Contraindications
  43. 43. Indications (Therapeutic uses)
  44. 44. DO”S ∗ Keep correct time ∗ Be attentive ∗ Hear and listen ∗ Take notes ∗ Be relaxed ∗ Maintain silence
  45. 45. DON”Ts ∗ Talk with others during lecture ∗ Use cellphones ∗ Call the names of your friends
  46. 46. Even thousands of miles of journey starts with a single step…….. lao tzu a chinese mystic
  47. 47. A JOKE TO END ∗ A chief doctor was on a practical demonstration of the two top most qualities of a skilful doctor to newly arrived young medical students with a patient ∗ He said, “listen my dear students… ∗ you must have keen observation and tolerance for becoming skilful and efficient”
  48. 48. ∗ Then He did a PerRectal examination in the patient and sucked his middle finger ∗ The students were amazed and stunned..! ∗ He asked “Now can any of you demonstrate this..?” ∗ There was a murmuring among the youngsters and slowly One student came forward with bravery
  49. 49. ∗ He did the P.R examination through his middle finger and sucked his middle finger with a disgusting face ∗ The senior doctor smiled to the student and said , good.. You have tolerance, but no observation and added I did P.R with my index finger and I sucked my middle finger……..

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