This document is a newsletter from the International Senologic and Oncologic Scientific Community (ISOSC) that provides information on recent publications in oncology and breast cancer research, upcoming conferences, and summaries of expert discussions on cancer treatment. It lists several new peer-reviewed articles on topics like HER2-positive breast cancer treatment and screening techniques. It also announces upcoming breast cancer and oncology conferences worldwide and provides summaries of expert workshops on treating cancers like breast cancer, kidney cancer, prostate cancer, and leukemia.

1. Senology Newsletter Page 1 of 3
Senology.org - Newsletter
International Senologic and Oncologic Scientific Community (ISOSC)
"Connecting specialists worldwide"
Editor-in-Chief: Gian Paolo Andreoletti, MD
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Literature Selection
Verma S et al.: "Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer", N Engl J Med.
2012 Oct 1. [Epub ahead of print]
Shim JS et al.: "Selective Inhibition of HER2-Positive Breast Cancer Cells by the HIV Protease
Inhibitor Nelfinavir", J Natl Cancer Inst. 2012 Oct 5. [Epub ahead of print]
Esposito A et al.: "Are there benefits in routine clinical practice of continuing trastuzumab after
progression for metastatic breast cancer patients?", Anticancer Drugs. 2012 Nov;23(10):1089-98
Hannouf MB et al.: "Cost-effectiveness of a 21-gene recurrence score assay versus Canadian clinical
practice in women with early-stage estrogen- or progesterone-receptor-positive, axillary lymph-node
negative breast cancer, BMC Cancer. 2012 Oct 2;12(1):447. [Epub ahead of print]
Vataire AL et al.: "Cost-effectiveness of a chemotherapy predictive test", Bull Cancer. 2012 Oct 5.
[Epub ahead of print]
Carayol M et al.: "Psychological effect of exercise in women with breast cancer receiving adjuvant
therapy: what is the optimal dose needed?", Ann Oncol. 2012 Oct 5. [Epub ahead of print]
Saadatmand SS et al.: "Breast density as indicator for the use of mammography or MRI to screen
women with familial risk for breast cancer (FaMRIsc): a multicentre randomized controlled trial", BMC
Cancer. 2012 Oct 2;12(1):440. [Epub ahead of print]
Bluekens AM et al.: "Comparison of Digital Screening Mammography and Screen-Film Mammography
in the Early Detection of Clinically Relevant Cancers: A Multicenter Study", Radiology. 2012 Oct 2.
[Epub ahead of print]
Zhao Y et al.: "High-resolution, low-dose phase contrast X-ray tomography for 3D diagnosis of human
breast cancers", Proc Natl Acad Sci U S A. 2012 Oct 22. [Epub ahead of print]
Berghoff AS et al.: "Brain-only metastatic breast cancer is a distinct clinical entity characterised by
favourable median overall survival time and a high rate of long-term survivors", Br J Cancer. 2012 Oct
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9 [Epub ahead of print]
Eirò N et al.: "Prediction of metastatic breast cancer in non-sentinel lymph nodes based on
metalloprotease-1 expression by the sentinel lymph node", Eur J Cancer. 2012 Oct 11[Epub ahead of
print]
Medhavan D et al.: "Circulating miRNAs as Surrogate Markers for Circulating Tumor Cells and
Prognostic Markers in Metastatic Breast Cancer", Clin Cancer Res. 2012 Oct 18. [Epub ahead of print]
Comment
"Preoperative needle biopsy improves the quality of surgery in women with breast cancer",Ted A.
James, Department of Surgery, University of Vermont College of Medicine, Burlington, VT, USA
"Our study demonstrates that obtaining a pre-operative diagnosis of cancer significantly improves surgical
outcomes with respect to margin control and the total number of operations required to treat a patient with
breast cancer. This translates into improved quality of care for the patient and a reduction in health care costs
associated with secondary procedures. As much as it is possible, attempts should be made to perform a
needle biopsy to confirm the presence of breast cancer prior to the patient going to the operating room.
Further study is required to better understand barriers to the use of pre-operative needle biopsies, and efforts
made to expand its use in the diagnosis breast cancer ".
(Commentary on: James TA et al.: "Preoperative needle biopsy improves the quality of breast cancer
surgery", J Am Coll Surg. 2012 Oct;215(4):562-8)
Discussion
"Regional nodal irradiation after a positive sentinel lymph node is a reasonable alternative to axillary dissection in
early breast cancer" - Share your opinion on LinkedIn®
Questions and Answers
Breast Cancer Medical Therapy Workshop Summary - with George Somlo, City of Hope Comprehensive
Cancer Center, Duarte, CA, USA
Breast Cancer Radiotherapy Workshop Summary - with Simona Shaitelman, Department of Radiation
Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Breast Cancer Genomic Profiling Workshop Summary - with Joseph Sparano, Albert Einstein College of
Medicine, New York, NY, USA
Fragments of History
1932 - Geoffrey Langdon Keynes in London uses radium as the sole treatment of operable cases of breast
cancer (Keynes GL.: "The radium treatment of carcinoma of the breast", Brit J Surg 1942;19:415–80)
Calendar of Events
Breast Cancer in Young Women Conference, November 8-10, 2012, Dublin, Ireland
IBUS - International Breast Ultrasound Course, November 13-15, 2012, Tel Aviv, Israel
8th Meet the Professor. Advanced International Breast Cancer Conference (AIBCC), November 15-17,
2012, Padova , Italy - with the Patronage of Senology.org
2012 CTRC-AACR San Antonio Breast Cancer Symposium, December 4-8, 2012, San Antonio, TX, USA
2nd San Marino Breast Forum, December 1, 2012, San Marino, San Marino, SRM
Literature Selection
Chaichana KL et al.: "Multiple resections for patients with glioblastoma: prolonging survival", J
Neurosurg. 2012 Oct 19. [Epub ahead of print]
Dillon KE et al.: "Pretreatment antimüllerian hormone levels determine rate of posttherapy ovarian
reserve recovery: acute changes in ovarian reserve during and after chemotherapy", Fertil Steril. 2012
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Oct 18 [Epub ahead of print]
Cheng AS et al.: "Helicobacter pylori Causes Epigenetic Dysregulation of FOXD3 to Promote Gastric
Carcinogenesis", Gastroenterology. 2012 Oct 8[Epub ahead of print]
Liao X et al.: "Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival", N Engl J Med.
2012 Oct 25;367(17):1596-606
Pizzichetta MA et al.: "Negative pigment network: An additional dermoscopic feature for the diagnosis
of melanoma", J Am Acad Dermatol. 2012 Oct 9 [Epub ahead of print]
Olmos D et al.: "Prognostic value of blood mRNA expression signatures in castration-resistant
prostate cancer: a prospective, two-stage study", Lancet Oncol. 2012 Oct 8 [Epub ahead of print]
Parent ME et al.: "Night Work and the Risk of Cancer Among Men", Am J Epidemiol. 2012 Oct 3. [Epub
ahead of print]
Bolla M et al.: "Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer:
long-term results of a randomised controlled trial (EORTC trial 22911)", Lancet. 2012 Oct 18 [Epub
ahead of print]
Questions and Answers
Kidney Cancer Workshop Summary 1 and Summary 2 - with Nicholas Vogelzang, Comprehensive Cancer
Centers of Nevada, Las Vegas, NV, USA, and with Scott Tykodi, University of Washington, Seattle, WA, USA
Prostate Cancer Workshop Summary 1 and Summary 2 - with Daniel Petrylak, Yale Cancer Center and
Smilow Cancer Hospital, Yale, New Haven, USA, and with Cy Stein, City of Hope, Duarte, CA, USA
Leukemia Workshop Summary - with Jonathan Kolitz, North Shore University Hospital/LIJ Medical Center,
New York, NY, USA
Myeloma Workshop Summary - with Craig Hofmeister, Ohio State University College of Medicine,
Columbus, OH, USA
Melanoma Workshop Summary - with Richard Joseph, Mayo Clinic, Florida, USA
Literature Selection
Schierbeck LL et al.: "Effect of hormone replacement therapy on cardiovascular events in recently
postmenopausal women: randomised trial", BMJ. 2012 Oct 9;345:e6409
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