Existing Preclinical Models for Parkinson's Disease R&D are not satisfactory. Not young But Relevant is a new preclinical model designed by Pharmaseed, which better mimics the disease by including in one model the most prominent disease's risk factors.

2. Dr NoClue,
How come that with 15
animals per arm
We can demonstrate drug
efficacy in Parkinson’s
Disease mouse model, yet
with 300 patients per arm
we can not?

3. Dear Dr Y, it is not so
complicated! Just have a look
at the disease mechanism

4. Dr NoClue…
So many parameters and
unknowns… where should
I start?
Feeling
hungry…what shall I
have for dinner?

5. Dr Y, it is simple! Start with
young mice, or even young
rats, and dosed them with
neurotoxins. Or we can use
transgenics, we have so many
wonderful models!
Didn’t we try them
already?...I want
to go shopping

6. I think I’ll have
some pasta, and
what about
dessert?

7. Dr Y, it is complicated to run
a study on aged animals that
are on a western diet…this is
not the way we were trained
to think!
Shoes…
I need new shoes

8. I lost my apetite…I need
to loose some weight. I
am getting old…almost
irrelevant

9. It might be a good idea to include the
known risk factors in one model…if you
think about it there aren’t too
many…just add aging, environmental
factors and western diet and you may
cover 80% of the risk factors
I need new glasses…I
hate the bifocal

10. 125 euros a pair…
30% discount but I
like them
Dr Y, it might be worth
including what we know about
PD risk factors in one « dirty »
model…we would be less
academic but so much more
relevant!!

11. I like your
innovative idea, so
simple and so
smart!
She likes me