The document discusses guidelines for discontinuing antiepileptic drug (AED) treatment in patients who have been seizure-free. It summarizes studies that identified factors associated with risk of seizure recurrence after stopping AEDs. For patients who are seizure-free for 2-5 years, have had only partial or generalized seizures, have a normal neurological exam and IQ, and a normalized EEG with treatment, the risk of recurrence is about 69% for children and 61% for adults. The guidelines recommend considering discontinuing AEDs for patients meeting these criteria. Future research is still needed to better predict individual patient risks.

1. Practice Parameter : A guideline for discontinuing antiepileptic drugs in seizure-free patients – Summary Statement Neurology 1996;47:600-602 Dr. Rafael Higashi (neurologist) Institute of Neurology Deolindo Couto UFRJ- Epilepsy Outpatient Unit www.estimulacaoneurologica.com.br

2. The Quality Standarts Subcommittee of The American Academy of neurology (AAN) Develops practice parameters for neurologists pertaining to diagnostic procedures, treatment modalities, and clinical desorders.

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