1.
SOFTWARE USED IN
FORMULATION DESIGN
PROCESS
SUBMITTED BY: SUBMITTED TO:
RAHUL PAL (FINALYEAR, VII SEM) MS. KARISHMA SINGH
DEPARTMENT OF PHARMACY

2.
DESIGN OF EXPERIMENT FOR
FORMULATION AND DEVELOPMENT
All pharmaceutical products are formulated to specific dosage from drugs to be effectively
delivered to patient typical pharmaceutical dosage from include, tablets, capsules, solutions and
suspensions etc.
- Formulation are a process of selection of components and processing.
- Now days computer tools used in the formulation and development of pharmaceutical
products.
In Pharmaceutics is the process in which different chemical substances, including the active drug, are
combined to produce a final medicinal Product.

3.
DRUG DESIGN PROCESS
 It is the inventive process of finding new medications based on the knowledge of a biological target.
Selected/Designed Molecules should be:
 Organic small molecule complementary in shape to the target.
 Oppositely charge to the biomolecules target.

4.
METHODS
Structure Based Drug Design Ligand Based Drug Design

5.
COMPUTER SOFTWARE
 There are several software which are used in the formulation process, mainly given below and
some of their features also including in: -
Software Silent feature
Design Expert Used for optimizing pharmaceutical
formulation and process
Minitab For Automated data analysis.
DOE PRO XL MS-Excel compatible DOE software for
automated data analysis
CARD For Data Analysis include graphics and
help feature

6.
Software for Drug Designing,
Formulation And Development
Sr. No. Pharmacological Activity Software Name Major use
01. Pharmacokinetics Properties DDDPlus/MapCheck Compare dose or Frequency
Measurement.
02. Ligand Interaction Schrodinger Ligand Receptor Docking
03. Structure Activity Relationship ArgusLab Molecular docking calculation
and molecular modeling
package
04. Image analysis and Visualizers Discovery Studio Visualizer Views and Analyse Protein
Data
05. Data Analysis QSARPro Protein-Protein Interaction
Study
06. Behavior Study MARS (Multimodal Animal
Rational System)
Animal Activity Tracking,
Enzyme activity

7.
Other Software
ChemDraw
Chemical Structure
Making, Conversion
Name and Structure
Structure
Cleanup, Its
Very Useful
SwissADME
Determine the
Pharmacokinetics
Parameters (ADME)
Support the Optimization
of the absorption,
Distribution, Metabolism,
Excretion

8.
CONCLUSIONS
 We have discussed different software based on different approaches that are playing major role
in the drug designing and drug discovery now days.
 Using design of experiment formulation scientist evaluate the all formulation factors in
systematically and timely manner to optimize the formulation and manufacturing process.
 Design of experiment and statistical analysis have used in the formulation development.
 The compute aided drug design has large number of success stories and continue to play a vital
role in the drug discovery process.
 In this regards, the approach has been utilized in proposing drug candidate against Corona
Virus Disease 2019 (COVID-19)

9.
THANK TOU