1. Epigenetics refers to heritable changes in gene expression that do not involve changes to the underlying DNA sequence. 2. Important epigenetic mechanisms include DNA methylation, histone modification, and microRNA involvement. These mechanisms play roles in normal development and cell differentiation. 3. Epigenetic changes can be influenced by environmental factors and behaviors. They also contribute to genomic imprinting and X-chromosome inactivation. 4. Abnormal epigenetic patterns are implicated in cancer development. Targeting epigenetic alterations offers potential for new cancer interventions.

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6. “
What beyond Genetics is playing here?

7. Epigenetics: Basic Concept
and Its Relationship with
Development and Cancer
Speaker,
Dr. Md. Mohiuddin Masum
MS Anatomy, Phase-A, Year-1, Block-1
Guided by,
Prof. K M Shamim
Professor, Dept. of Anatomy, BSMMU

8. “
• Define epigenetics
• Describe important epigenetic mechanism and explain the
implication of epigenetics in normal functions, disease and
disease presentation
Objective

9. “
• Outline the heritability or epigenetic effects
• Explain the role of epigenetic in the development of cancer
• Outline the potentials of epigenetic intervention in battling cancer
Objective
(contd.)

10. Epigenetics
Epi +
Genetics
Heritable changes
in gene expression
that operate outside of
changes in DNA itself

12. Chromosome Structure
Purines Pyrimidines

13. Chromosome Structure (contd.)

14. DNA Methylation

15. Histone Modification
ac
me
P
ub
acclt
Acetylation
Methylation
Phosphorylation
Ubiquination
Deimination

16. microRNA

17. Genetics
Environment
Behavior
Nutrition

20. Inactivation of X-chromosome
Barr Body

21. Differention of Pluripotent Stem Cells to
Somatic Cells

22. Genomic Imprinting
Working set Imprinted set
(and thus silenced)
Working set Imprinted set
(and thus silenced)
Combination- 1 Combination- 2
Normal
Non-working set Imprinted set
(and thus silenced)
Non-working set Imprinted set
(and thus silenced)
Father’s gene is imprinted (silenced)
Mothers gene is mutated (non-working)
Mother’s gene is imprinted (silenced)
Father’s gene is mutated (non-working)
Prader-Wili syndrome Angelman syndrome
♀ ♂ ♀♂
♀ ♂ ♀ ♂

24. Mother: 1st Generation
Fetus: 2nd Generation
Germ cells: 3rd Generation

26. Epigenetics
Genetics

29. Battling Cancer Using Epigenetics

30. Battling Cancer Using Epigenetics