DNA Sequencing: Emerging Technologies and Applications

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DNA Sequencing: Emerging Technologies and Applications
Published on July 2010

Report Summary

The worldwide market for sequencing products will grow from an estimated $1.3 billion in 2010 to more than $3.3 billion by 2015, a
compound annual growth rate (CAGR) of 20.5% over the next 5 years.

Life-science research and drug discovery and development applications represent the two largest markets for DNA sequencing
revenues, accounting for an estimated $920.1 million in 2010. These markets are forecast to grow at a compound annual growth rate
(CAGR) of 13% to reach nearly $1.7 billion in 2015.

Emerging applications, including personal genomics and clinical diagnostics, are forecast to account for $541.4 million by the year
2015, an increase from $15.5 million in 2010 representing a 103.5% compound annual growth rate (CAGR).

Table of Content

Chapter- 1: INTRODUCTION -- Complimentary

STUDY GOALS AND OBJECTIVES 1
REASONS FOR DOING THE STUDY 1
INTENDED AUDIENCE 2
SCOPE OF REPORT 2
METHODOLOGY 3
INFORMATION SOURCES 3
RELATED BCC REPORTS 3
ANALYST CREDENTIALS 4
BCC ONLINE SERVICES 4
DISCLAIMER 4

Chapter-2: EXECUTIVE SUMMARY

SUMMARY TABLE GLOBAL VALUE OF DNA SEQUENCING PRODUCTS, BY END-USE APPLICATION, THROUGH 2015 ($
MILLIONS) 5
SUMMARY FIGURE GLOBAL VALUE OF DNA SEQUENCING PRODUCTS, BY END-USE APPLICATION, 2009-2015 ($
MILLIONS) 6
EXECUTIVE SUMMARY (CONTINUED) 7

Chapter-3: OVERVIEW

INTRODUCTION 8
TABLE 1 SCOPE OF THIS REPORT 9
MARKET POTENTIAL OF DNA SEQUENCING PRODUCTS 9

DNA Sequencing: Emerging Technologies and Applications (From Slideshare) Page 1/13


TABLE 2 GLOBAL VALUE OF DNA SEQUENCING WORKFLOW PRODUCTS, BY TYPE, THROUGH 2015 ($ MILLIONS) 10
SEQUENCING INDUSTRY GROWTH DRIVING FORCES 11
TABLE 3 DNA SEQUENCING KEY GROWTH DRIVING FORCES 11
SEQUENCING INDUSTRY GROWTH ' (CONTINUED) 12
SEQUENCING PRODUCTS 13
SEQUENCING INSTRUMENTS 13
SEQUENCING CONSUMABLES 13
SEQUENCING PRODUCT LIFE CYCLE STATUS 14
TABLE 4 PRODUCT LIFE CYCLE STATUS OF SEQUENCING PLATFORMS 14
COMMERCIAL STATUS 15
SEQUENCING INDUSTRY 16
TABLE 5 SEQUENCING INSTRUMENT COMPETITORS, BY TECHNOLOGY 16
SEQUENCING INDUSTRY (CONTINUED) 17
Chapter-4: DNA SEQUENCING TECHNOLOGIES

GENETIC ANALYSIS 18
FIGURE 1 CENTRAL MOLECULAR BIOLOGY DOGMA 18
FIGURE 2 DNA, MRNA, AND GENETIC VARIATION 19
TABLE 6 SCOPE OF KEY GENETIC ANALYSIS TECHNOLOGIES 20
GENETIC ANALYSIS (CONTINUED) 21
HISTORY OF DNA SEQUENCING 22
TABLE 7 DNA SEQUENCING HISTORICAL TIMELINE 22
TABLE 7 (CONTINUED) 23
HISTORY OF DNA SEQUENCING (CONTINUED) 24
FIGURE 3 SEQUENCING COST TREND, BASE PAIRS SEQUENCED PER DOLLAR 27
FIGURE 4 SEQUENCING THROUGHPUT TREND 28
FIGURE 5 HUMAN GENOME SEQUENCING COST TREND, 2000-2015 (DOLLARS) 29
FIGURE 6 $1,000 GENOME PRODUCT SPACE 30
OVERVIEW OF SEQUENCING TECHNOLOGIES 31
TABLE 8 DNA SEQUENCING TECHNOLOGY PLATFORM COMPARISON 31
SANGER SEQUENCING 32
SANGER SEQUENCING TECHNOLOGY 32
FIGURE 7 DDNTP CHEMICAL STRUCTURE 33
FIGURE 8 SANGER SEQUENCING WORKFLOW 34
SANGER SEQUENCING COSTS 35
FIGURE 9 COST BREAKDOWN FOR SEQUENCING A SINGLE HUMAN GENOME, USING 2005 SANGER SEQUENCER
TECHNOLOGY (%) 36
LIMITATIONS OF SANGER SEQUENCING 37
TABLE 9 LIMITATIONS OF SANGER SEQUENCING TECHNOLOGY 37
TECHNOLOGY DEVELOPMENTS IN SANGER SEQUENCING 37
TABLE 10 IMPROVEMENTS IN SANGER SEQUENCING TECHNOLOGY 38
NEXT-GENERATION SEQUENCING TECHNOLOGIES 38
INTRODUCTION 38
NEXT-GENERATION SEQUENCING WORKFLOW 39
TABLE 11 NEXT-GENERATION SEQUENCING WORKFLOW STEPS 39
FIGURE 10 NEXT-GENERATION SEQUENCING TECHNOLOGIES 40



Next-generation Sequencing ' (Continued) 41
TABLE 12 WORKFLOW COMPARISON OF SELECTED NEXT-GENERATION DNA SEQUENCING PLATFORMS 42
TABLE 13 NEXT-GENERATION SEQUENCE PLATFORMS 43
FIGURE 11 SCHEMATIC COMPARISON OF ROCHE/454, LIFE TECHNOLOGIES, AND ILLUMINA SEQUENCING PLATFORMS 44
TABLE 14 NEXT-GENERATION SEQUENCING PLATFORM ADVANTAGES AND LIMITATIONS 45
SEQUENCING BY SYNTHESIS WITH REVERSIBLE TERMINATORS 45
FIGURE 12 SEQUENCING BY SYNTHESIS: REVERSIBLE TERMINATOR REACTION 46
PYROSEQUENCING 47
FIGURE 13 SEQUENCING BY SYNTHESIS: PYROSEQUENCING REACTION 48
SEQUENCING BY LIGATION 49
Sample Preparation 50
Sequencing Reaction 51
FIGURE 14 SCHEMATIC OF SOLID SEQUENCING BY LIGATION 51
Cycle 1 52
Cycle 2 52
Cycles 3 to 5 52
Decoding 52
FIGURE 15 DECODING SOLID COLOR DATA 53
THIRD-GENERATION SEQUENCING 54
Single-molecule Sequencing by Synthesis 54
Nanopore Sequencing 55
FIGURE 16 SINGLE-MOLECULE SEQUENCING BY SYNTHESIS 56
Nanopore Sequencing (Continued) 57
FIGURE 17 NANOPORE SEQUENCING WORKFLOW AND TECHNOLOGY APPROACHES 58
SEQUENCING TECHNOLOGY PLATFORMS COMPARED 60
TABLE 15 KEY PERFORMANCE METRICS FOR SEQUENCING TECHNOLOGIES 60
TABLE 16 COST AND PERFORMANCE COMPARISON OF SELECTED NEXT- AND THIRD-GENERATION DNA SEQUENCING
PLATFORMS 61
Sequencing Technology ' (Continued) 62
SEQUENCING PRODUCT LIFE CYCLE 63
TABLE 17 LIFE CYCLE OF DNA SEQUENCING TECHNOLOGIES 63
SEQUENCING INSTRUMENT CUMULATIVE INSTALLED BASE 64
FIGURE 18 GLOBAL CUMULATIVE INSTALLED BASE OF DNA SEQUENCERS, THROUGH APRIL 2010 (%) 64
SEQUENCE READ LENGTH 65
TABLE 18 READ LENGTHS FOR SELECTED SEQUENCING PLATFORMS 65
SEQUENCER PERFORMANCE SPACE 66
FIGURE 19 SEQUENCING COMPETITIVE MARKET SPACE 67
END-USER SWITCHING 68
PAIRED-END READS 69
TABLE 19 STRENGTHS AND LIMITATIONS OF PAIRED-END READS 70
BARCODING 71
DNA POLYMERASES 71
SEQUENCING BIOINFORMATICS 72
TABLE 20 INFORMATICS WORKFLOW FOR NEXT-GENERATION SEQUENCING 72
TECHNOLOGY CHALLENGES FOR NEXT-GENERATION PLATFORMS 73
TABLE 21 TECHNOLOGY CHALLENGES FOR NEXT-GENERATION SEQUENCING 74



Technology Challenges ' (Continued) 75

Chapter-5: DNA SEQUENCING APPLICATIONS

INTRODUCTION 76
FIGURE 20 WHOLE GENOME SEQUENCING PROJECTS FOR PROKARYOTES AND EUKARYOTES, AS OF APRIL 2010
(NUMBER OF GENOMES SEQUENCED) 76
FIGURE 20 (CONTINUED) 77
FIGURE 21 WHOLE GENOME SEQUENCING EUKARYOTIC PROJECTS, BY TYPE, AS OF APRIL 2010 77
RESEARCH AND DRUG DISCOVERY APPLICATIONS 78
INTRODUCTION 78
Introduction (Continued) 79
TABLE 22 GENETIC ANALYSIS FORMATS COMPARISON 80
TABLE 23 SEQUENCING APPLICATIONS 81
TABLE 24 DE NOVO VERSUS RESEQUENCING REQUIREMENTS 82
DE NOVO SEQUENCING 82
De Novo Human Sequencing 82
De Novo Microbial Sequencing 83
TABLE 25 CASE STUDY 1: NEANDERTHAL DNA SEQUENCING 84
RESEQUENCING 85
Whole Genome Resequencing (Genome-wide Association Studies or Loci Discovery) 85
FIGURE 22 RELATIVE NUMBER OF DISEASE-CAUSING ALLELES AT MAF5 AND MAF1 86
FIGURE 23 SINGLE SEQUENCER, WHOLE GENOME THROUGHPUT TRENDS 1975-2015 87
Targeted Resequencing 88
SEQ-BASED METHODS 89
TABLE 26 GENETIC ANALYSIS APPLICATIONS WHERE SEQUENCING COMPETES WITH MICROARRAYS 89
Chromatin Immunoprecipitation Applications 90
TABLE 27 COMPARISON OF SEQUENCING WITH MICROARRAYS FOR CHIP APPLICATIONS 90
DNase-seq 91
Gene Expression Analysis 91
TABLE 28 COMPARISON OF SEQUENCING AND MICROARRAYS FOR GENE EXPRESSION ANALYSIS 92
MethylSeq 93
DNA Mutation Studies 94
Complementary Sequencing and Microarray Platforms Drive Market Growth 94
DIAGNOSTICS AND DRUG DISCOVERY 95
FIGURE 24 APPLICATIONS SPACE WITH INTENSE TECHNOLOGY COMPETITION 96
FIGURE 25 APPLICATIONS SPACE WITH INTENSE TECHNOLOGY COMPETITION 97
DIAGNOSTICS AND DRUG DISCOVERY (CONTINUED) 98
DIAGNOSTICS AND DRUG DISCOVERY (CONTINUED) 99
PERSONAL GENOMICS 100
FIGURE 26 GENETIC ANALYSIS COST/INFORMATION CONTENT TRENDS 101

Chapter-6: DNA SEQUENCING INITIATIVES

INTRODUCTION 102
FIGURE 27 NIH FUNDING AWARDS, BY INSTITUTE, FOR DNA SEQUENCING ' RELATED PROJECTS, 2009-2010 (%) 103
NHGRI $1,000 GENOME PROJECT FUNDING 104



TABLE 29 NHGRI GRANTS UNDER $1,000 GENOME PROGRAM, FY2009 ($) 104
FIGURE 28 NHGRI $1,000 GENOME PROJECT AWARDS VALUE, FY2007- FY2009 ($ MILLIONS) 105
FIGURE 29 $1,000 GENOME PROJECT AWARDS, BY TECHNOLOGY, 2007-2009 (%) 106
SEQUENCING-RELATED GENOMICS PROJECTS OVERVIEW AND STATUS 107
TABLE 30 IMPORTANT SEQUENCING RESEARCH INITIATIVES 107
GENOME SEQUENCING PROJECTS 109
Functional Genomics in Norway (FUGE) II 109
Personal Genome Project 110
Archon X Prize in Genomics 110
Genomes 10K Project 111
1,000 Plant and Animal Reference Project 111
MEDICAL SEQUENCING PROJECTS 111
Mapped Autosomal Mendelian Disorders 112
Allelic Spectrum in Common Disease Program 112
Clinseq Project 112
CANCER SEQUENCING PROJECTS 113
Cancer Genome Project 113
Tumor Sequencing Project (TSP) 113
The Cancer Genome Atlas 113
MICROBIAL SEQUENCING PROJECTS 114
Human Microbiome Project 115
Microbial Genome Sequencing Project 115
Marine Microbial Genome Sequencing Project 116
Fungal Genome Initiative 116
Pathogen Sequencing Program 116
Genomic Encyclopedia of Bacteria and Archaea (GEBA) 117
Metagenomics of the Human Intestinal Tract (MetaHIT) 117
Gut Microbiome Initiative 118
10,000 Microbial Genomes Project 118
GENOME VARIATION PROJECTS 119
Encyclopedia of DNA Elements (ENCODE) 119
1,000 Genomes Project 120
1,000 Plant Genomes Project 120
Resequencing Technology Program 121
Human Genome Structural Variation Project 122
Yanhuang Project 123
AGRICULTURAL GENOMICS 123
National Plant Genome Initiative 123
EPIGENOMICS SEQUENCING PROJECTS 124
TABLE 31 EPIGENOMICS INITIATIVES 125
EUROPE 126
UNITED STATES 127
United States (Continued) 128
ASIA 129
IMPACT OF SEQUENCING PROJECTS 129



FIGURE 30 GROWTH IN BASE PAIRS DEPOSITED IN GENBANK, 1988-2008 (BILLIONS) 130

Chapter-7: DNA SEQUENCING INDUSTRY STRUCTURE

INDUSTRY STRUCTURE ANALYSIS 131
FIGURE 31 DNA SEQUENCING INDUSTRY STRUCTURE, 1995-2005 132
FIGURE 32 DNA SEQUENCING INDUSTRY STRUCTURE: POST 2005 133
INDUSTRY STRUCTURE ANALYSIS (CONTINUED) 134
TABLE 32 DNA SEQUENCING INDUSTRY TRANSITION 135
THE ROLE OF EARLY ADAPTORS 135
SEQUENCING INSTRUMENT COMPETITOR POSITIONING 136
FIGURE 33 SEQUENCER PLATFORM POSITIONING BY READS AND READ LENGTH 137
TABLE 33 SEQUENCING INSTRUMENT COMPETITORS, BY TECHNOLOGY 137
Sequencing Instrument ' (Continued) 139
Sequencing Instrument ' (Continued) 140
SEQUENCING SAMPLE PREPARATION INDUSTRY 141
TABLE 34 POSITIONING OF SEQUENCE ENRICHMENT FORMATS 141
TABLE 35 SEQUENCING SAMPLE PREPARATION COMPANY POSITIONING 142
Sequencing Sample ' (Continued) 143
SEQUENCING BIOINFORMATICS INDUSTRY 144
TABLE 36 DNA SEQUENCING BIOINFORMATICS COMPANY POSITIONING 144
SEQUENCING SERVICES INDUSTRY 145
TABLE 37 DNA SEQUENCING SERVICES COMPANY POSITIONING, BY MARKET FOCUS 146
SEQUENCING INSTRUMENTS COMPETITOR MARKET SHARES 147
FIGURE 34 ESTIMATED COMPETITOR MARKET SHARE: SEQUENCING INSTRUMENTS AND REAGENTS, 2009 (%) 147
FIGURE 35 ESTIMATED COMPETITOR MARKET SHARE: SANGER SEQUENCING INSTRUMENTS AND REAGENTS,
2009 (TOTAL MARKET $466.2 MILLION) (%) 148
FIGURE 36 ESTIMATED COMPETITOR MARKET SHARE: NEXT-GENERATION SEQUENCING INSTRUMENTS AND
REAGENTS, 2009 (TOTAL MARKET $607.4 MILLION) (%) 150
Sequencing Instruments ' (Continued) 151
INDUSTRY ACQUISITIONS AND STRATEGIC ALLIANCES 152
TABLE 38 SEQUENCING INDUSTRY ACQUISITIONS, 2007-2010 153
Industry Acquisitions ' (Continued) 154
TABLE 39 SEQUENCING INDUSTRY STRATEGIC ALLIANCES, 2007-2010 155
SEQUENCING REAGENTS SUPPLY ALLIANCES 158
PERSONAL GENOMICS INDUSTRY DYNAMICS 158
TABLE 40 MEDIUM TO HIGH CONTENT DTC GENETIC TESTING KEY COMPETITORS 159
FIGURE 37 PERSONAL GENOMICS COMPETITIVE SPACE, BY TEST COST AND SCOPE 160
TABLE 41 PERSONAL GENOMICS COMPETITOR STRATEGIES 161
Personal Genomics ' (Continued) 162
DNA SEQUENCING END USERS 163
TABLE 42 DNA SEQUENCING END-USER MARKET SEGMENTS 163
Major Sequencing Centers 163



TABLE 43 NEXT-GENERATION SEQUENCING INSTRUMENT INSTALLATIONS, BY MAJOR SEQUENCING CENTER, 2010 164
Major Sequencing Centers (Continued) 165
FIGURE 38 MAJOR SEQUENCING CENTER'S SHARE OF THE GENOME SEQUENCING PROJECTS MARKET BY NUMBER OF
SEQUENCING PROJECTS, APRIL 2010 (%) 166
FIGURE 39 BEIJING GENOMICS INSTITUTE ADOPTION OF NEXT-GENERATION SEQUENCERS, 2008 AND 2010 (NUMBER OF
SEQUENCERS) 167
Large Core Sequencing Centers 168
TABLE 44 EXAMPLES OF LARGE CORE SEQUENCING CENTERS 168
Small to Mid-size Laboratories 169
Sequencing Service Laboratories 169
Sequencing Service ' (Continued) 170

Chapter-8: DNA SEQUENCING MARKETS

GROWTH DRIVING FORCES 171
TABLE 45 DNA SEQUENCING KEY GROWTH DRIVING FORCES 171
GROWTH DRIVING FORCES (CONTINUED) 172
GROWTH DRIVING FORCES (CONTINUED) 173
FIGURE 40 EUKARYOTIC SEQUENCING PARADIGM 174
GENETIC ANALYSIS MARKETS 175
TABLE 46 GLOBAL VALUE OF GENETIC ANALYSIS MARKET, BY ANALYSIS TYPE, THROUGH 2015 ($ MILLIONS) 176
FIGURE 41 SNP GENOTYPING MARKET 177
GENETIC ANALYSIS MARKETS (CONTINUED) 178
DNA SEQUENCING PRODUCTS MARKETS 179
DNA SEQUENCING MARKETS BY PRODUCT TYPE 179
TABLE 47 GLOBAL VALUE OF DNA SEQUENCING WORKFLOW PRODUCTS, BY TYPE, THROUGH 2015 ($ MILLIONS) 179
DNA Sequencing ' (Continued) 180
TABLE 48 GLOBAL VALUE OF DNA SEQUENCING INSTRUMENT AND CONSUMABLES MARKET, BY PRODUCT TYPE,
THROUGH 2015 ($ MILLIONS) 181
DNA SEQUENCING MARKETS BY SANGER AND NEXT-GENERATION FORMATS 182
FIGURE 42 GLOBAL VALUE OF SEQUENCING INSTRUMENTS AND CONSUMABLES, BY TECHNOLOGY PLATFORM, 2010
AND 2015 (DOLLARS) 182
TABLE 49 GLOBAL VALUE OF DNA SEQUENCING INSTRUMENTS, BY PLATFORM, THROUGH 2015 ($ MILLIONS) 184
TABLE 50 GLOBAL VALUE OF DNA SEQUENCING CONSUMABLES MARKET, BY PLATFORM, THROUGH 2015 ($ MILLIONS)
185
DNA SEQUENCING MARKETS BY END USER 186
TABLE 51 GLOBAL VALUE OF DNA SEQUENCING INSTRUMENTS AND CONSUMABLES, BY CUSTOMER TYPE, THROUGH
2015 ($ MILLIONS) 186
DNA Sequencing ' (Continued) 187
TABLE 52 GLOBAL VALUE OF SANGER SEQUENCING INSTRUMENTS AND CONSUMABLES, BY CUSTOMER, THROUGH
2015 ($ MILLIONS) 188
TABLE 53 GLOBAL VALUE OF NEXT-GENERATION SEQUENCING INSTRUMENTS AND CONSUMABLES, BY CUSTOMER,
DNA SEQUENCING MARKETS BY TECHNOLOGY 190
TABLE 54 GLOBAL VALUE OF DNA SEQUENCING INSTRUMENTS AND CONSUMABLES MARKET, BY TECHNOLOGY,
DNA SEQUENCING MARKETS BY END-USER APPLICATION 192



TABLE 55 GLOBAL VALUE OF DNA SEQUENCING, BY END-USE APPLICATION, THROUGH 2015 ($ MILLIONS) 193
Research and Drug Discovery and Development 193
Forensic and Human ID 194
Bacterial Genomics 195
Agricultural Genomics 195
Clinical Diagnostics 196
TABLE 56 LABORATORIES DEVELOPING NEXT-GENERATION SEQUENCING DX TESTS 197
Personal Genomics 197
Personal Genomics (Continued) 198
Other Applications 199
TABLE 57 GLOBAL VALUE OF NEXT-GENERATION SEQUENCING INSTRUMENTS AND CONSUMABLES, BY END-USE
APPLICATION, THROUGH 2015 ($ MILLIONS) 200
Other Applications (Continued) 201
TABLE 58 GLOBAL VALUE OF SANGER SEQUENCING INSTRUMENTS AND CONSUMABLES, BY END-USE APPLICATION,
DNA SEQUENCING MARKETS BY GENOME TYPE 203
TABLE 59 GLOBAL VALUE OF SEQUENCING, BY GENOME TYPE, THROUGH 2015 ($ MILLIONS) 203
DNA Sequencing Markets (Continued) 204
DNA SEQUENCING MARKETS BY ANALYSIS TYPE 205
TABLE 60 GLOBAL VALUE OF DNA SEQUENCING, BY ANALYSIS TYPE, THROUGH 2015 ($ MILLIONS) 206
TABLE 61 GLOBAL VALUE OF NEXT-GENERATION SEQUENCING, BY ANALYSIS TYPE, THROUGH 2015 ($ MILLIONS) 207
TABLE 62 GLOBAL VALUE OF SANGER SEQUENCING, BY ANALYSIS TYPE, THROUGH 2015 ($ MILLIONS) 208
DNA SEQUENCING MARKETS BY GEOGRAPHY 209
TABLE 63 GLOBAL VALUE OF DNA SEQUENCING PRODUCTS, BY GEOGRAPHICAL MARKET, THROUGH 2015 ($ MILLIONS)
209
TABLE 64 GLOBAL VALUE OF SANGER SEQUENCING PRODUCTS, BY GEOGRAPHICAL MARKET, THROUGH 2015 ($
MILLIONS) 210
TABLE 65 GLOBAL VALUE OF NEXT-GENERATION SEQUENCING PRODUCTS, BY GEOGRAPHICAL MARKET, THROUGH
2015 ($ MILLIONS) 211
DNA Sequencing Markets ' (Continued) 212

Chapter-9: DNA SEQUENCING PATENT STATUS

RECENT PATENT ACTIVITY IN NEXT-GENERATION DNA SEQUENCING 213
TABLE 66 NEXT-GENERATION SEQUENCING PATENT RECENT ACTIVITY 213
Sequencing by Synthesis 214
Single-molecule Sequencing 215
Nanopore Sequencing 215
Polony Sequencing 216
Nucleotide Modifications and Analogs 216
DNA Polymerases 217
Paired-end Inventions 217
Other Methods 218
PATENT POSITION OF SEQUENCING COMPETITORS 218
FIGURE 43 SEQUENCING-RELATED PATENTS, BY COMPANY (NUMBER OF PATENTS) 218
TECHNOLOGY DISTRIBUTION OF NEXT-GENERATION SEQUENCING PATENTS 220



FIGURE 44 GLOBAL NEXT-GENERATION SEQUENCING PATENTS, BY TECHNOLOGY, 2001-2009 220
GEOGRAPHICAL DISTRIBUTION OF NEXT-GENERATION SEQUENCING PATENTS 221
FIGURE 45 GLOBAL NEXT-GENERATION SEQUENCING-RELATED PATENTS, BY GEOGRAPHY, 2000-2009 (NUMBER OF
PATENTS) 222
SEQUENCING LITIGATION STATUS 223
TABLE 67 SEQUENCING IP LITIGATION STATUS 223
SEQUENCING LITIGATION STATUS (CONTINUED) 224
INTELLECTUAL PROPERTY POSITION OF SELECTED SEQUENCING COMPANIES 225
LIFE TECHNOLOGIES 225
LI-COR BIOSCIENCES 226
HELICOS BIOSCIENCES 227
ILLUMINA 227
INTELLIGENT BIO-SYSTEMS 228
PACIFIC BIOSCIENCES 228

Chapter-10: COMPANY PROFILES

23ANDME 229
AFFOMIX CORPORATION 230
AFFYMETRIX, INC. 230
AGILENT TECHNOLOGIES, INC. 231
AGILENT TECHNOLOGIES, INC. (CONTINUED) 232
ARTEMIS HEALTH, INC. 233
BASE4INNOVATION, LTD. 233
BECKMAN COULTER 233
BECKMAN COULTER (CONTINUED) 234
BIO.LOGIS CENTER FOR HUMAN GENETICS 235
BIONANOMATRIX, INC. 235
BIOTIQUE SYSTEMS INC. 236
CALIPER LIFE SCIENCES 236
CALIPER LIFE SCIENCES (CONTINUED) 237
CALIPER LIFE SCIENCES (CONTINUED) 238
COLLABRX, INC. 239
COMPLETE GENOMICS, INC. 240
CONEXIO GENOMICS 240
CORRELAGEN DIAGNOSTICS, INC. 241
DANAHER MOTION 242
DECODEME 243
DELTADOT, LTD. 244
DNANEXUS, INC. 244
DNA STAR, INC. 245
ELECTRONIC BIOSCIENCES 245
EUROFINS MEDIGENOMIX GMBH 245
EXPRESSION ANALYSIS, INC. 246
FASTERIS SA 246
FEBIT BIOTECH GMBH 247
FIREBIRD BIOMOLECULAR SCIENCES, LLC 248
FLUIDIGM CORPORATION 248



FLUIDIGM CORPORATION (CONTINUED) 249
FOUNDATION FOR APPLIED MOLECULAR EVOLUTION 250
GATC BIOTECH AG 250
GE HEALTHCARE 251
GENEDATA AG 252
GENOME DIAGNOSTICS B.V 252
GENOMEQUEST, INC. 253
GENOMATIX SOFTWARE, INC. 254
GENOVOXX GMBH 254
GEOSPIZA, INC. 255
HALCYON MOLECULAR 256
HELICOS BIOSCIENCES CORPORATION 256
INTERNATIONAL BUSINESS MACHINES CORP. 257
ILLUMINA, INC. 258
ILLUMINA, INC. (CONTINUED) 259
TABLE 68 ILLUMINA SEQUENCING TECHNOLOGY SPACE 260
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE 261
INTELLIGENT BIO-SYSTEMS 262
INTERNA GENOMICS BV 263
ION TORRENT SYSTEMS 264
IP GENESIS INC. 264
ISENTIO AS 265
KNOME, INC. 265
LASERGEN, INC. 266
LI-COR BIOSCIENCES 266
LIFE TECHNOLOGIES, INC. 267
LIFE TECHNOLOGIES, INC. (CONTINUED) 268
LIFE TECHNOLOGIES, INC. (CONTINUED) 269
LIFECODEXX 270
LIGHTSPEED GENOMICS 270
LINGVITAE AS 271
MICROCHIP BIOTECHNOLOGIES, INC. 271
MWG BIOTECH AG 272
MYCROARRAY.COM 273
NABSYS, INC. 273
NAVIGENICS 274
NETWORK BIOSYSTEMS 275
NEWGENE, LTD. 276
NUGEN TECHNOLOGIES, INC. 277
OLINK GENOMICS AB 277
OPGEN, INC. 278
OXFORD NANOPORE TECHNOLOGIES 278
PACIFIC BIOSCIENCES 279
PACIFIC BIOSCIENCES (CONTINUED) 280
POPULATION GENETICS TECHNOLOGIES, LTD. 281
QUANTALIFE, INC. 282
RAINDANCE TECHNOLOGIES, INC. 283
REAL TIME GENOMICS 284



REVEO INC. 284
ROCHE LIFE SCIENCES 285
ROCHE LIFE SCIENCES (CONTINUED) 286
ROCHE LIFE SCIENCES (CONTINUED) 287
SEIRAD, INC. 288
SEQUENOM, INC. 288
SEQUENOM, INC. (CONTINUED) 289
SEQUENOM, INC. (CONTINUED) 290
SEQWRIGHT 291
SHIMADZU SCIENTIFIC INSTRUMENTS 292
SMARTGENE 292
SOURCE BIOSCIENCES, PLC. 293
SORENSON GENOMICS 293
U.S. GENOMICS 293
VISIGEN BIOTECHNOLOGIES, INC. 294
X-PRIZE FOUNDATION 295
ZS GENETICS 295


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