1. HORMONES AND CANCER HORMONES AND CANCER Richin john koshy

2. OVERVIEW: HORMONES HORMONE DEPENDENT CANCER RISK FACTORS CAUSING CANCER PATHOPHYSIOLOGY THERAPEUTIC MEDICATIONS CONCLUSION

3. Hormones are peptide or a steroid which is produced by a tissue and conveyed to the bloodstream to the target organs for maturation Hormones are involved in growth and development of an individual

4. HORMONE DEPENDENT CANCERS: Hormones share a strong bond in cancer and its progression and the role in which hormones play in cancer are seen in breast ,prostate and ovaries

5. RISK FACTORS : BREAST CANCER Null Parity Early Menarche Late Menopause Hormone Replacement Theraphy High Fat Diet Oral Contraceptive Pills ? DEBATE

6. RISK FACTORS:PROSTATE CANCER Ethnic group Androgen receptor

7. PATHOPHYSIOLOGY

10. ANTI ANDROGENS :Bicalutamide and Nilutamide which block the binding of androgen to receptors are commonly used as a hormonal therapy GNRH AGONIST :Leuprolide acetate or Goserelin acetate can be given which eventually leads to chemical castration

14. Conclusion Breast and Prostate tumours have a common feature in that at some stage in their evolution they were hormone dependent cancers, and therefore hormone therapy is an intuitively obvious therapeutic approach

15. Refrences Risbridger ,G.P et al.Breast and prostate cancer more similiar than diffrent .Nature (2010) Ricke, W. A. et al. Prostatic hormonal carcinogenesis ismediated by in situ estrogen production and estrogen trial. J. Urol. 176, 965–970 (2006) Ma, X. J., Dahiya, S., Richardson, E., Erlander, M. &Sgroi, D. C. Gene expression profiling of the tumor microenvironment during breast cancer progression.BreastCancer Res. 11, 7 (2009).