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BIOTECH 
CROWDFUNDING 
BY ROB L I T T LEF I ELD
WHY CROWDFUNDING? 
• Longstanding tradition in US of generous support for research at places 
like the Dana-Farber Cancer Institute or UC San Francisco 
• Many of those donors want to take the next step by investing in companies 
building on that research to develop treatments 
• While most biotech companies are for-profit, creating therapies for 
diseases and then bringing them to the market may appeal to the 
crowd 
• In particular: patients, friends and family, medical practitioners and researchers 
for whom finding a cure for unmet diseases is an urgent and highly emotional 
matter and may be more important than realizing a return on investment 
• People are often willing to donate money to a not-for-profit charity 
dedicated to medical or bioscience research. 
• Crowdfunding appeals to this population as it might allow them to directly impact 
on medical innovation in a fully transparent manner i.e. it will be clear to them 
where their money is going and for what purpose 
2
HOW TO ATTRACT INTEREST 
• Studies show most important factors for investors are 
1. Perceived market potential 
2. Prior experience of the entrepreneur 
3. Being personally moved by the idea of the business 
• Crowdfunding is a form of ‘activism’ & a way to make an 
impact by supporting US businesses that reflects the 
investor’s own values 
• Many feel it is important people beyond the very wealthy 
have an opportunity to fund small businesses 
• Driven by ‘potential to do good deeds’ rather than to realize a ROI 
3
CURRENT CROWDFUNDING MARKET 
• Jumpstart Our Business Startups (JOBS) Act in Fall of 
2013 SEC released new regulations on crowdfunding 
• Early-stage firms struggle to attract investors 
• Terribly hard - more difficult than it ever has been 
• Consulting firms help esoteric and complex work of biotech firms 
• >250 "biotech" startups seeking capital on AngelList 
• Mostly genomics, DIY, diagnostic, or life science service 
• Several therapeutic startups, for example, Rodin 
4
DRAWBACKS 
• Time for innovation is lengthy 
• High failure rate is unattractive 
• Unsophisticated public may not understand 
biotechnology/scientific propositions 
• High-level of due diligence for individual investors 
• Proprietary information rights & IP issues 
• May prove unattractive to business angels 
• Administrative burden of paperwork, registration, 
regulation, tax 
• No warranties for further funding round/no exit 
5
TYPES OF FUNDING 
Equity I 
• Allows for accredited investors to view private investment opportunities on a 
password-protected website 
• Suit entrepreneurs who want to avoid public exposure of their fundraising 
campaigns 
Equity II 
• Can raise an unlimited amount of capital from an unlimited number of accredited 
investors 
• All done through equity crowdfunding portals which make it simple to advertise their 
offerings across the web 
• Most popular type of equity crowdfunding, it exposes entrepreneurs to a huge 
audience of potential investors (6-8 million accredited investors in US) 
Equity III 
• Allows unaccredited investors to participate (the 99%) 
• With platforms to offer and sell securities online, entrepreneurs will enjoy the ability 
to potentially reach out to over 50 million Americans 
• More regulatory requirements to manage 
6
ANGEL FUNDING MARKET 
• Angel investing of $20bn per year across all sectors 
• 21% start-ups in Healthcare services/Medtech 
• 8% in Biotech (1500/yr) 
• Fewer than 100 biotech startups are backed by angels with 
more than $500K in any given year 
• Angel investing driven locally or through networks around 
successful pharma executives 
7
TOP BIOTECH CROWDFUNDING SITES 
1. Poliwogg 
2. Healthcare Hatch / Indiegogo 
3. WiSeed 
4. Medstartr 
5. DoDo Funding 
6. CrowdCube 
7. Seedr 
8. Consano 
9. Oncology Crowd AU 
8
POLIWOGG 
• Healthcare specific, NY-based, well-connected 
• Not individuals, focuses on equity investors 
• <20 life science companies listed for crowdfunding, many 
more in review ($1-$4million min) 
• SEC limit on non-accredited investors of just $1million per 
year (will eventually lift) 
• Realize more value quickly with small donations – this will 
help a startup appeal to serious investors 
• Equity-based crowdfunding has volumes of paperwork, 
very complex, prohibitively burdensome 
• All-or-Nothing funding of $2m - $10m 
9 www.poliwogg.com
INDIEGOGO 
• International crowdfunding site where anyone can raise 
money for film, music, art, charity, small businesses, 
gaming, theater, and more 
• Biotech Example: J147: Therapeutics for ALS 
• Funding histopathology (microscopic tissue examination) lab work to 
better analyze the results for study ongoing at Salk Institute 
• Originally seeking $30K (see: J147 Crowd Funding Site) 
10 
www.indiegogo.com
WISEED 
• European (Fr) equity-based crowdfunding website 
• WiSEED community = 20,000 potential investors 
• Vote on 10 projects/month, audit, choose 3, can raise $50,000 to 
$685,000 against equity stake of 5-20% of company (min invest 
of $100) 
• All individual investments combined into a single holding 
company, dedicated exclusively to this investment, in which 
investors hold a stake. Platform monitors and maintain 
communication 
• Initial review, e-voting, due diligence (audit), valuation (not a 
financial study but intended to give a value to the project, based 
on the assumptions of revenues and expenses in relation to 
expectations from market society) 
• WiSEED has helped 27 companies raise $6+ million in equity 
funding 
11 www.wiseed.com
ROCKETHUB 
• Keep all funds raised (not “all-or-nothing”) 
• Reach goal: 4% commission fee + 4% credit card handling 
fee 
• Don’t reach goal: 8% commission fee + 4% credit card 
handling fee 
• Focus on art, science, business and social good projects 
http://www.rockethub.com/abo1u2t
MEDSTARTR/MEDFUNDR 
• Patient, doctors, companies funding healthcare innovation 
• Most small funds $10k-$20k, nothing in biotech 
• Mostly hardware/software, consumer, product/device 
• Focus on small projects for small medical problems 
www.medstartr.com 13
DODO FUNDING 
• "Crowdfunding platform for biotech projects” 
• Goal sum, 90 days, 5% commission to DoDo, uses PayPal 
• “If selected by committee, get public exposure, marketing and 
communication help…” 
• Rewards: 
• Acknowledgements in scientific papers 
• Personal updates 
• Insight into how research is going 
• Finalize products 
• Equity in the company 
• All-or-Nothing platform 
• Bioengineering, bioinformatics, DNA barcoding, education, 
genomics, metagenomics, nanobiotechnology, proteomics, 
synthetic biology, transcriptomics 
www.dodofunding.com 14
CROWDCUBE 
• Founded in 2010, London-based CrowdCube is the next 
generation of business investment. 
• It is a new way to fund start-ups and business expansion by 
crowdfunding for equity, giving entrepreneurs a platform to connect 
with people and raise venture capital. 
• Mostly professional services, internet businesses, 
consumer 
www.crowdcube.com 15
SEEDRS 
• Equity capital platform, very friends and family 
• “For an investment of $150,000, between 20% and 40% of 
your company's equity is what investors are likely to 
expect. 
• The average equity offered by startups on Seedrs is in the 
10% to 50% range” 
• $10,000 - $300,000 with 1-40% equity 
16 
www.seedrs.com
CONSANO 
• Consano brings crowd-funding to the world of medical 
research 
• Donation based, focus on healing 
• $25,000 - $1,500,000, 2 months time frame 
• Receive money whether or not goal reached 
• Only 15 projects listed on website 
17 
www.consano.org
BLAZEFUND 
• Equity crowdfunding in business services, technology, 
consumer, energy, software, internet, healthcare & life 
sciences 
• Equity shares 
• Convertible debt 
• Partnership options 
• No real healthcare projects ongoing, did help Perle 
• Many closed 
18 
www.blazefund.com
INVESTING ZONE 
• Equity-based platform; 10-90% of company 
• Projects ranging from $200,000 to $800,000 
• Not healthcare specific in any way, no biotech 
• “Adopted the principles of crowdfunding to connect 
businesses with its network of angel investors” 
19 
www.investingzone.com
ONCOLOGYCROWD AU 
• “There are few crowdfunding sites dedicated to scientific 
research and even less to oncology which is surprising 
considering the number of consumers that are passionate 
about improving patient outcomes” 
• Recently launched 
• Oncology “Hive” networking platform coming soon 
20 
www.oncologycrowd.com.au
OTHER WEBSITES 
1. Health Tech Hatch (hardware, $10K avg) 
2. CircleUp (mostly consumer/retail) 
3. iCrowd (rather basic platform) 
4. RocketHub (mostly consumer/retail) 
5. Petridish.org (DIY, science, nature) 
6. Flintwave (Dutch crowdfunding, science focus) 
7. IAmScientist (science and tech) 
8. Longecity ($4K - $16K research funding) 
9. Dragon Innovation (hardware products) 
10. CrowdCure (life science projects) 
11.OpenGenius (research projects) 
12. PledgeIt (UK charity for leukemia and lymphoma) 
13. TechMoola (crowdfunding for inventions, tech) 
14. Experiment.com (was Microryza, science <$10K, lmtd) 
15. Xconomy (news and analytics site) 
16. Syndicate Room (equity crowdfunding) 
17. Crowdnetic (tech/mrkt data for crowdfunding) 
21
EXAMPLES OF BIOTECH FUNDING 
• WiSEED 
• IndieGoGo 
• CrowdCube 
22
WiSEED 
www.antabio.com 
23
• Developers of innovative drugs against cancer 
• Fundraising closed $1.1m on WiSEED 
24 
www.urodelia.com
• Cell Guidance Systems make research tools to aid stem 
cell scientists 
• Stem cells are being developed to provide treatments for 
diseases increasing stroke, coronary disease, diabetes 
and Parkinson's. 
• CrowdCube, funded. $400,000 with 138 investors, 290% 
target, 14.55% equity offered 
25 
www.cellgs.com
• French biotech developing first-in-class candidate-drugs 
• Support neural repair in order to treat traumatic or severe 
degenerative disorders of the CNS and to contribute to the 
restoration of neurological function, and thus to improve the quality 
of life of patients. 
• In 2012, Neuronax used WiSEED to facilitate series ‘A’ 
financing of clinical trials in spinal cord injury. 
• $1,234,000 in first funding, min of $100 per invest 
26 
www.neuronax.com
• Development of novel antimicrobial products 
• Emerging crisis of antibiotic resistance for microbial pathogens in 
the US & throughout the world 
• Was seeking $2 - $3m in equity investment for XF-73 as of 
late-2013 on CrowdCure 
27 
www.destinypharma.com
• Ambiotis is the first Contract Research Organization (CRO) 
working on the active resolution of the inflammatory 
process and making the proof of concept of innovative 
compounds. 
• WiSEED platform fund raising closed with $137,000 
28 
www.ambiotis.com
• Proprietary peptide therapy to generate new insulin 
producing cells; reversing Type 1 & 2 diabetes 
• BlazeFund to raise target $2m 
29 
www.perlebioscience.com
• Develops anti-cancer drugs 
• Raised funds on WiSEED, sought $140,000 
30 
www.selexel.com
VENTURE HEALTH 
• Investment portal for accredited investors 
• 3 funded companies featured here 
• Rani Therapeutics 
• NFocus Neuromedical 
• Channel Medsystems 
31 
www.venturehealth.com
Founded by Mir Imran, Rani Therapeutics is developing a 
technology that would make biotherapeutics orally available 
- removing the need for subcutaneous or intramuscular 
injections. The company has successfully delivered a well-known, 
commercially available antibody in a pre-clinical 
model. 
• Most Recent Financing: Raised its Series B in August of 
2013, led by Google Ventures 
• Venture Health: raised $2.6M 
www.ranitherapeutics.com 
32
• Founded by Mir Imran and Martin Dieck, Nfocus is 
developing breakthrough solutions for neurovascular 
disease, starting with brain aneurysms. Now completing 
initial human trials in Europe, the company’s LUNA device 
is demonstrating dramatic improvements in outcomes for 
aneurysm patients. 
• Exit: Acquired by Covidien on February 19, 2013 See 
article here... 
• Most Recent Financing: VentureHealth group: invested 
$1.49M 
www.nfocusneuro.com 
33
• Founded by Dan Burnett, MD, Channel Medsystems is 
creating the first truly office-based Global Endometrial Ablation 
(GEA) technology, based on innovations in cryo-therapy. GEAs 
are used to treat excessive menstrual bleeding as an 
alternative to more invasive surgical procedures. Channel’s 
device is designed to quickly and safely deliver therapy in a 
single use, self-contained, hand-held device that is well 
tolerated by the patient. 
• Most Recent Financing: Raised $9.7M in April 2013, led by 
Boston Scientific and Venture Health 
• Venture Health: invested $875,000 
www.channelmedsystems.com 
34
RODIN THERAPEUTICS 
• Novel treatment for Alzheimer's disease; drug inhibits 
target to enhance the expression of genes critical for the 
formation of new memories to slow cognitive decline and 
improve QoL 
• Seed of $1.7m Jul 1, 2013 - Atlas Venture, Proteros 
Biostructures and Johnson & Johnson, Venture Health 
35 
www.rodintherapeutics.com
• About 
• Small device reads and sequences DNA and converts it into binary 
code using a tiny computer chip (malaria drug resistance) 
• Campaign Hook 
• By contributing to this campaign, you are furthering development of our 
device and readying it for mass manufacture. Most importantly, you are 
providing malaria tests for hundreds if not thousands of children in 
Africa as part of a large clinical trial. We're also giving you an 
opportunity to leave a legacy by helping to name our device, and 
design the look and feel of it. 
• Campaign Non-Financial Goals 
• Support development and clinical trials; lab to field 
• Campaign Financial Goals/Totals 
• Indiegogo $18,035 of $50,000 (36%) Feb 12 – March 31, 2014 (47d) 
36 
http://www.indiegogo.com/projects/the-future-quantumdx-s-handheld- 
dna-lab
• Rewards Promised 
• $10 shout-out 
• $25 sticker, email updates 
• $35 t-shirt 
• $50 Coffee mug 
• $7,000 travel to UK, goody bag 
• Deliverables Promised 
• $145 Lab coat 
• $75 Dx test to African child, famous photo 
• $225 Dx test to 3 African children 
• $695 Dx test to 10 African children, t-shirt, phone call 
• $2,500 Dx test to African class, t-shirt, phone call 
• $50,000 fund satellite clinical trial in new location 
37 
http://www.indiegogo.com/projects/the-future-quantumdx-s-handheld- 
dna-lab
Marketing Materials 
• Comprehensive, well-produced video 
• Logos of news sources covering the company and with 
quotes 
• Bullet-point content with pictures on tech and device, 
picture of team, discussing development and partners 
• Campaign video from Pins and Needles Media 
• Company also on Facebook, Twitter, Youtube, and has own 
website 
38 
http://www.quantumdx.com/
• About 
• Tech that measures DNA damage: 
• “Exogen Biotechnology is a health startup aimed at developing cutting-edge 
technologies for individuals to monitor damage to their DNA and to assess their DNA 
repair capacities for the purposes of personalized and preventive health care” 
• Campaign Hook 
• “Campaign is not about the money, and the contributions for the perks will 
hardly cover our expenses. This campaign is a citizen science project, and 
our target is about gathering data to look at how age, medical conditions, 
environmental and lifestyle factors correlate with DNA damage.” 
• No FDA, research and info only 
• Campaign Non-Financial Goals 
• Gathering big data by covering some of the costs. 
• Campaign Financial Goals/Totals 
• Ingiegogo: $50k goal (January 25, 2014 – March 26, 2014) 
• Achieved: $20k 3 days, $50k 10 days, $106k 60 days (212%) 
39 
www.exogen.com
• Rewards Promised 
• $15 name on website 
• $25 t-shirt 
• Deliverables Promised 
• $99 US kit (3 samples) 
• $124 non-US kit (3 samples) 
• $179 US kits (2x3 samples) 
• $204 non-US Kits (2x3 samples) 
• $359 US 4 kits over 1 year 
• $459 non-US 4 kits over 1 year 
• $399 family US kits (4x3 samples) 
• $439 family non-US kits (4x3 samples) 
• $999 US monthly tracker (12 kits) 
• $1,299 non-US monthly tracker 
• $5,000 monthly self-tracker, visit facilities and meet team 
40 
www.exogen.com
• Marketing Materials 
• Comprehensive video with fancy transitions, music, graphics, 
simulation of DNA breaking and device working, video of 
scientists/labs, interviews 
• Pictures and profiles of team & advisory board 
• FAQ 
• Updates 
• Company is also on Facebook, Twitter, YouTube and has its own 
website (with overview, team info, tutorial on DNA damage, and a 
news blog) 
41 
www.exogen.com
• About 
• Direct-to-consumer microbiome sequencing company (SF, CA) 
• Campaign Hook 
• Sequence your microbiome through citizen science 
• Campaign Non-Financial Goals 
• Citizen science, data acquisition and international outreach 
• Campaign Financial Goals 
• Indiegogo: goal $100k (Nov 15, 2012 – Feb 18, 2013) 
• Achieved: $351k in 94 days (352%) 
42 
www.ubiome.com
• Rewards Promised 
• $5 shout-out 
• $25 t-shirt 
• Deliverables Promised 
• $79 GI Microbiome kit 
• $89 GI Microbiome Kit + t-shirt 
• $139 GI and Oral Microbiome kit + t-shirt 
• $148 2x GI Microbiome kit (1 for you, 1 for Africa) + t-shirt 
• $209 IBD: 3 GI kits for different time points 
• $235 IBD: 3 GI kits for different time points + web app for personal experiments + 
t-shirt 
• $335 GI, Mouth, Skin, Nose and Genital Microbiome kits + t-shirt 
• $1,337 5xkits to use at 5 different time points + personal guidance + t-shirt 
• $10,000 consultation with scientists, visit lab, all kits 
43 
www.ubiome.com
• Marketing Materials 
• Comprehensive video describing product, physiology, etc. 
• Logos of selected press and news 
• Quotes from Key Opinion Leaders 
• Descriptions, content on microbes, body, how it works, pictures 
• Advisory board 
• Facebook (2,000+ likes), Twitter (5,400+ followers), YouTube (<5 
videos), Website (welcome, how it works, order now, simple and 
effective website) 
• Mailing list, kit ordering 
44 
www.ubiome.com
• About 
• Applied Integrin Sciences, Inc. discovers, develops and commercializes protein drug 
therapies for cancer treatments that reduce solid tumor growth and progression, and 
improve patient survival and quality of life. AIS is a socially responsible organization 
in drug development and targets the ovarian cancer indication for the intraperitoneal 
tumors as an orphan disease. 
• Campaign Hook 
• Involvement matters, impact will be huge, donation focused, 100% tax deductible 
with matching partners 
• Campaign Non-Financial Goals 
• Accelerate the availability of drug discovered at Norris Cancer Center that fights 
Ovarian, Breast & Prostate cancers. Need $200k to demonstrate “drugability” where 
drug discovery becomes drug development. With $500k, will have drug manufactured 
under FDA. With $1m will fulfill pre-requirements for investigational NDA with FDA, 
begin human clinical trials. VC and pharma expected to finance after this phase. 
• Campaign Financial Goals 
• Raised $86,000 of $200,000 goal | Launched 8/29/2013 ended 12/16/2013 (109d) 
• Tax deductible donation to cancer research 
45 
http://www.whenyouwish.com/project/boostcancersurvivalrates
• Rewards Promised 
• $5 pen 
• $10 shout out, email updates 
• $20 ribbon signed by CEO 
• $50 two free move tickets 
• $50 coffee gift card ($25) 
• $50 in memory of dead, shout out 
• $100 in memory of loved one, name listed 
• $150 just because (nothing) 
• $250 your story featured on website w/ video/text 
• $500 phone conversation w CEO, story featured 
• $1,000 story of crowdfunding campaign, tips, stats, lessons learned 
• $1,001 lunch w CEO and story featured 
• $2,500 crwdfnd story PDF w tips, contacts, etc, your story, company logo as 
sponsor 
• $4,999 Dinner with scientists or CEO flies to you 
• $5,000 sponsor, workshop w creative team from AIS that developed the 
crowdfunding campaign, seminar on crowdfunding 
46 
http://www.whenyouwish.com/project/boostcancersurvivalrates
• Marketing Materials 
• Executive summary 
• Company purpose, market & opportunity, management & advisors, product & 
technology, business model, financial, thesis 
• http://www.whenyouwish.com/upload/fa820770-7066-476e-b335-e77815928266.pdf 
• Fact sheet 
• http://www.whenyouwish.com/upload/dd7291db-8c10-4486-87e7-fd532485da5a.pdf 
• Development Funding Sought: Private equity (Series A), partnerships, grants for 
aggregate commitments of $22.0 million are sought; distributed in three success‐based 
milestone tranche investments to finance the company through Phase IIb clinical trials: 
1) prepare for and file IND for Phase I/IIa human clinical trial ($3.0 million); 2) Conduct 
Phase I/Iia clinical trial/mfn. drug doses ($5.0 million); 3) conduct Phase IIb clinical trial 
($14 million). 
• Presentation on company 
• Non-Confidential science presentation 
• http://www.whenyouwish.com/upload/9472f5f9-30bd-407d-ab10-0f915c71eca8.pdf 
47
• Start A Cure is a fundraising project for cancer research 
created by Malecare. 
• New York, NY 501(c)3 nonprofit 
• Raises funds and awareness, distributed 92% of funds 
(cite 16-65% for most foundations and gov’t agencies 
distribute) 
• John’s Hopkins research on prostate cancer treatment ($8k, met 
Dec ’13) 
• www.facebook.com/StartACure 
• Limited Twitter activity 
• Contact: Darryl Mitteldorf darryl@malecare.org 
48 
https://startacure.com/
Name of Fund on .com website Organizer Raised # Pledgers Avg Pledge Goal 
% 
Goal 
development of bioactive anti-cancer drug Beth Israel Deaconess $ 30 3 $10 $ 45,000 0% 
Pre-clinical testing optimized prostate cancer NKT-'Gvax' vaccine Brigham & Women's $ 185 4 $46 $ 30,000 1% 
Live-cell prostate cancer diagnostic Cellanyx $ 27 3 $9 $ 13,500 0% 
Develop guide for how to diet after prostate cancer Dx Columbia University $ 20 2 $10 $ 50,000 0% 
Characterize pathways in prostate cancer Dana Farber Cancer Inst $ 50 1 $50 $ 50,000 0% 
Study to analyze prostate Dx, whites vs blacks John Hopkins professor $ 8,113 33 $246 $ 8,000 101% 
testosterone therapy for prostate cancer John Hopkins professor $ 2,900 14 $207 $ 25,000 12% 
PTEN biomarker for CT prostate cancer John Hopkins professor $ 105 3 $35 $ 50,000 0% 
Zytiga and Xtandi drug development John Hopkins professor $ 480 5 $96 $ 30,000 2% 
molecular raiotherapy for metastic prostate cancer John Hopkins professor $ 55 3 $18 $ 30,000 0% 
Heat ablation w HPV vaccine for anal precancers LA Gay & Lesbian Center R&D $ 20 2 $10 $ 50,000 0% 
genetic signature to identify men with risk of prostate cancer 
progression MD Anderson Cancer Center, TX $ 75 1 $75 $ 50,000 0% 
nanoparticle based thermal therapy and DD Medical Nanotechnologies, Inc. $ 440 9 $49 $ 10,000 4% 
Probing porstate cancer metastasis by circulating tumor cells UCLA $ 316 5 $63 $ 50,000 1% 
Using bacteria to cure prostate cancer University of California Irvine $ 15 1 $15 $ 50,000 0% 
drug to augment effectiveness of androgen deprivation University of Pittsburgh $ 220 5 $44 $ 8,000 3% 
Development of anti-insulin resistant drugs for obese University of Texas Anderson Cancer Center $ 26 2 $13 $ 45,000 0% 
Fighting prostate cancer w breast cancer drugs University of Toronoto $ 198 4 $50 $ 30,000 1% 
Cell-cell interaction in cancer development University of Washington $ 100 2 $50 $ 50,000 0% 
49 
Economics of cryotherapy for prostate cancer Winthrop University Hospital $ 10 1 $10 $ 35,000 0%
JOHN HOPKINS' PROSTATE STUDY 
• Description of the study 
• Limited social media presence 
50
PHARMA SAFE (ROCKETHUB) 
• Drug abuse deterrent alarm and lock (device) 
• Rewards Promised 
• $10 Thank You 
• $25 label pin 
• $100 t-shirt, 
• Deliverables Promised 
• $250 actual device 
51 
http://www.rockethub.com/projects/35359-pharmasafe
THE FLYING SYRINGE (ROCKETHUB) 
• West Nile Virus proof-of-concept idea to genetically modify 
mosquito populations 
• Rewards Promised 
• $5 Thank You 
• $10 Wristband 
• $25 email updates 
• $50 t-shirt, wrist band 
• $100 t-shirt, 3D molecule 
• $250 Skype call 
• $750 Skype call, virtual tour 
• $1,500 Skype call, daytime visit 
http://research.bergen.org/index.php/12-front-page-slider/ 
52 
60-provita-rockethubm
NANOMEDICINE DRUGS FOR AIDS 
VIRUS 
• FAILED in 203: Only Raised $10 
• http://www.rockethub.com/projects/11875-potential-nanomedicine- 
drug-for-aids-virus 
• Has rewards for up to $5K 
53
• Kids with rare or incurable diseases 
• Tax-deductible gift 
• Rewards Promised 
• $25 thank you 
• $100 “adopt a drug candidate” 
• $1,000 “adopt many drug candidates” for a classroom 
• $3,000 “adopt many drug candidates” for a classroom, wrist band, 
education website 
• $5,000 “adopt many drug candidates” for a classroom, wrist band, 
education website, 3 hours of Skype with scientist 
• $10k all above, scientist comes to school to present, + family 
dinner 
• $25k dinner with director 
54
SOME KEY CROWDFUNDING FOLKS 
• Krist Weling, partner at law firm McDermott WIll & Emergy (lawyer) 
• Thierry Merquiol, partner at France-based WiSeed (investor) 
• Souleymane-Jean Galadima, associate at WiSeed (investor) 
• Lorenzo Pellegrini, VC with Care Capital in Princeton, NJ (investor) 
• Barbara Nelson, consultant, Nelson Biomedical (consultant) 
• Gregory Simon, CEO, Poliwogg financial firms (investor) 
• Elaine Warburton, CEO and cofounder of QuantuMDx (funding) 
• Sylvain Costes, cofounder of Exogen (biotech) 
• Jon Tang, cofounder of Exogen (biotech) 
• David Miller, president of Biotech Stock Research in Seattle (research) 
55
TAKEAWAY: KEY POINTS 
• Helps to have network in place or expert support 
• Exposure on funding website can be crucial 
• Relevant content, news, interesting material (blog) 
• Comprehensive video 
• Many different donation amounts with different rewards 
(some real, some feel-good) 
• Heartstrings effect (bettering of society) 
• Rewards do not have to be deliverables 
• Meet the team, see the lab, view the science 
• Facebook and Twitter involvement to expand crowd but is 
not completely necessary 
56
ABOUT THE AUTHOR 
Rob Littlefield graduated from Columbia University in the City of New York 
with a Master of Science degree in Biomedical Engineering and Bucknell 
University with a Bachelor of Science degree in Biomedical Engineering. He 
currently is a medical device senior market research analyst for GlobalData 
Healthcare and lives in Waltham, MA with his wife, Lara, Founder and CEO 
of BWD inc. 
{ contact@roblittlefield.com } 
57

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Biotech Crowdfunding

  • 1. BIOTECH CROWDFUNDING BY ROB L I T T LEF I ELD
  • 2. WHY CROWDFUNDING? • Longstanding tradition in US of generous support for research at places like the Dana-Farber Cancer Institute or UC San Francisco • Many of those donors want to take the next step by investing in companies building on that research to develop treatments • While most biotech companies are for-profit, creating therapies for diseases and then bringing them to the market may appeal to the crowd • In particular: patients, friends and family, medical practitioners and researchers for whom finding a cure for unmet diseases is an urgent and highly emotional matter and may be more important than realizing a return on investment • People are often willing to donate money to a not-for-profit charity dedicated to medical or bioscience research. • Crowdfunding appeals to this population as it might allow them to directly impact on medical innovation in a fully transparent manner i.e. it will be clear to them where their money is going and for what purpose 2
  • 3. HOW TO ATTRACT INTEREST • Studies show most important factors for investors are 1. Perceived market potential 2. Prior experience of the entrepreneur 3. Being personally moved by the idea of the business • Crowdfunding is a form of ‘activism’ & a way to make an impact by supporting US businesses that reflects the investor’s own values • Many feel it is important people beyond the very wealthy have an opportunity to fund small businesses • Driven by ‘potential to do good deeds’ rather than to realize a ROI 3
  • 4. CURRENT CROWDFUNDING MARKET • Jumpstart Our Business Startups (JOBS) Act in Fall of 2013 SEC released new regulations on crowdfunding • Early-stage firms struggle to attract investors • Terribly hard - more difficult than it ever has been • Consulting firms help esoteric and complex work of biotech firms • >250 "biotech" startups seeking capital on AngelList • Mostly genomics, DIY, diagnostic, or life science service • Several therapeutic startups, for example, Rodin 4
  • 5. DRAWBACKS • Time for innovation is lengthy • High failure rate is unattractive • Unsophisticated public may not understand biotechnology/scientific propositions • High-level of due diligence for individual investors • Proprietary information rights & IP issues • May prove unattractive to business angels • Administrative burden of paperwork, registration, regulation, tax • No warranties for further funding round/no exit 5
  • 6. TYPES OF FUNDING Equity I • Allows for accredited investors to view private investment opportunities on a password-protected website • Suit entrepreneurs who want to avoid public exposure of their fundraising campaigns Equity II • Can raise an unlimited amount of capital from an unlimited number of accredited investors • All done through equity crowdfunding portals which make it simple to advertise their offerings across the web • Most popular type of equity crowdfunding, it exposes entrepreneurs to a huge audience of potential investors (6-8 million accredited investors in US) Equity III • Allows unaccredited investors to participate (the 99%) • With platforms to offer and sell securities online, entrepreneurs will enjoy the ability to potentially reach out to over 50 million Americans • More regulatory requirements to manage 6
  • 7. ANGEL FUNDING MARKET • Angel investing of $20bn per year across all sectors • 21% start-ups in Healthcare services/Medtech • 8% in Biotech (1500/yr) • Fewer than 100 biotech startups are backed by angels with more than $500K in any given year • Angel investing driven locally or through networks around successful pharma executives 7
  • 8. TOP BIOTECH CROWDFUNDING SITES 1. Poliwogg 2. Healthcare Hatch / Indiegogo 3. WiSeed 4. Medstartr 5. DoDo Funding 6. CrowdCube 7. Seedr 8. Consano 9. Oncology Crowd AU 8
  • 9. POLIWOGG • Healthcare specific, NY-based, well-connected • Not individuals, focuses on equity investors • <20 life science companies listed for crowdfunding, many more in review ($1-$4million min) • SEC limit on non-accredited investors of just $1million per year (will eventually lift) • Realize more value quickly with small donations – this will help a startup appeal to serious investors • Equity-based crowdfunding has volumes of paperwork, very complex, prohibitively burdensome • All-or-Nothing funding of $2m - $10m 9 www.poliwogg.com
  • 10. INDIEGOGO • International crowdfunding site where anyone can raise money for film, music, art, charity, small businesses, gaming, theater, and more • Biotech Example: J147: Therapeutics for ALS • Funding histopathology (microscopic tissue examination) lab work to better analyze the results for study ongoing at Salk Institute • Originally seeking $30K (see: J147 Crowd Funding Site) 10 www.indiegogo.com
  • 11. WISEED • European (Fr) equity-based crowdfunding website • WiSEED community = 20,000 potential investors • Vote on 10 projects/month, audit, choose 3, can raise $50,000 to $685,000 against equity stake of 5-20% of company (min invest of $100) • All individual investments combined into a single holding company, dedicated exclusively to this investment, in which investors hold a stake. Platform monitors and maintain communication • Initial review, e-voting, due diligence (audit), valuation (not a financial study but intended to give a value to the project, based on the assumptions of revenues and expenses in relation to expectations from market society) • WiSEED has helped 27 companies raise $6+ million in equity funding 11 www.wiseed.com
  • 12. ROCKETHUB • Keep all funds raised (not “all-or-nothing”) • Reach goal: 4% commission fee + 4% credit card handling fee • Don’t reach goal: 8% commission fee + 4% credit card handling fee • Focus on art, science, business and social good projects http://www.rockethub.com/abo1u2t
  • 13. MEDSTARTR/MEDFUNDR • Patient, doctors, companies funding healthcare innovation • Most small funds $10k-$20k, nothing in biotech • Mostly hardware/software, consumer, product/device • Focus on small projects for small medical problems www.medstartr.com 13
  • 14. DODO FUNDING • "Crowdfunding platform for biotech projects” • Goal sum, 90 days, 5% commission to DoDo, uses PayPal • “If selected by committee, get public exposure, marketing and communication help…” • Rewards: • Acknowledgements in scientific papers • Personal updates • Insight into how research is going • Finalize products • Equity in the company • All-or-Nothing platform • Bioengineering, bioinformatics, DNA barcoding, education, genomics, metagenomics, nanobiotechnology, proteomics, synthetic biology, transcriptomics www.dodofunding.com 14
  • 15. CROWDCUBE • Founded in 2010, London-based CrowdCube is the next generation of business investment. • It is a new way to fund start-ups and business expansion by crowdfunding for equity, giving entrepreneurs a platform to connect with people and raise venture capital. • Mostly professional services, internet businesses, consumer www.crowdcube.com 15
  • 16. SEEDRS • Equity capital platform, very friends and family • “For an investment of $150,000, between 20% and 40% of your company's equity is what investors are likely to expect. • The average equity offered by startups on Seedrs is in the 10% to 50% range” • $10,000 - $300,000 with 1-40% equity 16 www.seedrs.com
  • 17. CONSANO • Consano brings crowd-funding to the world of medical research • Donation based, focus on healing • $25,000 - $1,500,000, 2 months time frame • Receive money whether or not goal reached • Only 15 projects listed on website 17 www.consano.org
  • 18. BLAZEFUND • Equity crowdfunding in business services, technology, consumer, energy, software, internet, healthcare & life sciences • Equity shares • Convertible debt • Partnership options • No real healthcare projects ongoing, did help Perle • Many closed 18 www.blazefund.com
  • 19. INVESTING ZONE • Equity-based platform; 10-90% of company • Projects ranging from $200,000 to $800,000 • Not healthcare specific in any way, no biotech • “Adopted the principles of crowdfunding to connect businesses with its network of angel investors” 19 www.investingzone.com
  • 20. ONCOLOGYCROWD AU • “There are few crowdfunding sites dedicated to scientific research and even less to oncology which is surprising considering the number of consumers that are passionate about improving patient outcomes” • Recently launched • Oncology “Hive” networking platform coming soon 20 www.oncologycrowd.com.au
  • 21. OTHER WEBSITES 1. Health Tech Hatch (hardware, $10K avg) 2. CircleUp (mostly consumer/retail) 3. iCrowd (rather basic platform) 4. RocketHub (mostly consumer/retail) 5. Petridish.org (DIY, science, nature) 6. Flintwave (Dutch crowdfunding, science focus) 7. IAmScientist (science and tech) 8. Longecity ($4K - $16K research funding) 9. Dragon Innovation (hardware products) 10. CrowdCure (life science projects) 11.OpenGenius (research projects) 12. PledgeIt (UK charity for leukemia and lymphoma) 13. TechMoola (crowdfunding for inventions, tech) 14. Experiment.com (was Microryza, science <$10K, lmtd) 15. Xconomy (news and analytics site) 16. Syndicate Room (equity crowdfunding) 17. Crowdnetic (tech/mrkt data for crowdfunding) 21
  • 22. EXAMPLES OF BIOTECH FUNDING • WiSEED • IndieGoGo • CrowdCube 22
  • 24. • Developers of innovative drugs against cancer • Fundraising closed $1.1m on WiSEED 24 www.urodelia.com
  • 25. • Cell Guidance Systems make research tools to aid stem cell scientists • Stem cells are being developed to provide treatments for diseases increasing stroke, coronary disease, diabetes and Parkinson's. • CrowdCube, funded. $400,000 with 138 investors, 290% target, 14.55% equity offered 25 www.cellgs.com
  • 26. • French biotech developing first-in-class candidate-drugs • Support neural repair in order to treat traumatic or severe degenerative disorders of the CNS and to contribute to the restoration of neurological function, and thus to improve the quality of life of patients. • In 2012, Neuronax used WiSEED to facilitate series ‘A’ financing of clinical trials in spinal cord injury. • $1,234,000 in first funding, min of $100 per invest 26 www.neuronax.com
  • 27. • Development of novel antimicrobial products • Emerging crisis of antibiotic resistance for microbial pathogens in the US & throughout the world • Was seeking $2 - $3m in equity investment for XF-73 as of late-2013 on CrowdCure 27 www.destinypharma.com
  • 28. • Ambiotis is the first Contract Research Organization (CRO) working on the active resolution of the inflammatory process and making the proof of concept of innovative compounds. • WiSEED platform fund raising closed with $137,000 28 www.ambiotis.com
  • 29. • Proprietary peptide therapy to generate new insulin producing cells; reversing Type 1 & 2 diabetes • BlazeFund to raise target $2m 29 www.perlebioscience.com
  • 30. • Develops anti-cancer drugs • Raised funds on WiSEED, sought $140,000 30 www.selexel.com
  • 31. VENTURE HEALTH • Investment portal for accredited investors • 3 funded companies featured here • Rani Therapeutics • NFocus Neuromedical • Channel Medsystems 31 www.venturehealth.com
  • 32. Founded by Mir Imran, Rani Therapeutics is developing a technology that would make biotherapeutics orally available - removing the need for subcutaneous or intramuscular injections. The company has successfully delivered a well-known, commercially available antibody in a pre-clinical model. • Most Recent Financing: Raised its Series B in August of 2013, led by Google Ventures • Venture Health: raised $2.6M www.ranitherapeutics.com 32
  • 33. • Founded by Mir Imran and Martin Dieck, Nfocus is developing breakthrough solutions for neurovascular disease, starting with brain aneurysms. Now completing initial human trials in Europe, the company’s LUNA device is demonstrating dramatic improvements in outcomes for aneurysm patients. • Exit: Acquired by Covidien on February 19, 2013 See article here... • Most Recent Financing: VentureHealth group: invested $1.49M www.nfocusneuro.com 33
  • 34. • Founded by Dan Burnett, MD, Channel Medsystems is creating the first truly office-based Global Endometrial Ablation (GEA) technology, based on innovations in cryo-therapy. GEAs are used to treat excessive menstrual bleeding as an alternative to more invasive surgical procedures. Channel’s device is designed to quickly and safely deliver therapy in a single use, self-contained, hand-held device that is well tolerated by the patient. • Most Recent Financing: Raised $9.7M in April 2013, led by Boston Scientific and Venture Health • Venture Health: invested $875,000 www.channelmedsystems.com 34
  • 35. RODIN THERAPEUTICS • Novel treatment for Alzheimer's disease; drug inhibits target to enhance the expression of genes critical for the formation of new memories to slow cognitive decline and improve QoL • Seed of $1.7m Jul 1, 2013 - Atlas Venture, Proteros Biostructures and Johnson & Johnson, Venture Health 35 www.rodintherapeutics.com
  • 36. • About • Small device reads and sequences DNA and converts it into binary code using a tiny computer chip (malaria drug resistance) • Campaign Hook • By contributing to this campaign, you are furthering development of our device and readying it for mass manufacture. Most importantly, you are providing malaria tests for hundreds if not thousands of children in Africa as part of a large clinical trial. We're also giving you an opportunity to leave a legacy by helping to name our device, and design the look and feel of it. • Campaign Non-Financial Goals • Support development and clinical trials; lab to field • Campaign Financial Goals/Totals • Indiegogo $18,035 of $50,000 (36%) Feb 12 – March 31, 2014 (47d) 36 http://www.indiegogo.com/projects/the-future-quantumdx-s-handheld- dna-lab
  • 37. • Rewards Promised • $10 shout-out • $25 sticker, email updates • $35 t-shirt • $50 Coffee mug • $7,000 travel to UK, goody bag • Deliverables Promised • $145 Lab coat • $75 Dx test to African child, famous photo • $225 Dx test to 3 African children • $695 Dx test to 10 African children, t-shirt, phone call • $2,500 Dx test to African class, t-shirt, phone call • $50,000 fund satellite clinical trial in new location 37 http://www.indiegogo.com/projects/the-future-quantumdx-s-handheld- dna-lab
  • 38. Marketing Materials • Comprehensive, well-produced video • Logos of news sources covering the company and with quotes • Bullet-point content with pictures on tech and device, picture of team, discussing development and partners • Campaign video from Pins and Needles Media • Company also on Facebook, Twitter, Youtube, and has own website 38 http://www.quantumdx.com/
  • 39. • About • Tech that measures DNA damage: • “Exogen Biotechnology is a health startup aimed at developing cutting-edge technologies for individuals to monitor damage to their DNA and to assess their DNA repair capacities for the purposes of personalized and preventive health care” • Campaign Hook • “Campaign is not about the money, and the contributions for the perks will hardly cover our expenses. This campaign is a citizen science project, and our target is about gathering data to look at how age, medical conditions, environmental and lifestyle factors correlate with DNA damage.” • No FDA, research and info only • Campaign Non-Financial Goals • Gathering big data by covering some of the costs. • Campaign Financial Goals/Totals • Ingiegogo: $50k goal (January 25, 2014 – March 26, 2014) • Achieved: $20k 3 days, $50k 10 days, $106k 60 days (212%) 39 www.exogen.com
  • 40. • Rewards Promised • $15 name on website • $25 t-shirt • Deliverables Promised • $99 US kit (3 samples) • $124 non-US kit (3 samples) • $179 US kits (2x3 samples) • $204 non-US Kits (2x3 samples) • $359 US 4 kits over 1 year • $459 non-US 4 kits over 1 year • $399 family US kits (4x3 samples) • $439 family non-US kits (4x3 samples) • $999 US monthly tracker (12 kits) • $1,299 non-US monthly tracker • $5,000 monthly self-tracker, visit facilities and meet team 40 www.exogen.com
  • 41. • Marketing Materials • Comprehensive video with fancy transitions, music, graphics, simulation of DNA breaking and device working, video of scientists/labs, interviews • Pictures and profiles of team & advisory board • FAQ • Updates • Company is also on Facebook, Twitter, YouTube and has its own website (with overview, team info, tutorial on DNA damage, and a news blog) 41 www.exogen.com
  • 42. • About • Direct-to-consumer microbiome sequencing company (SF, CA) • Campaign Hook • Sequence your microbiome through citizen science • Campaign Non-Financial Goals • Citizen science, data acquisition and international outreach • Campaign Financial Goals • Indiegogo: goal $100k (Nov 15, 2012 – Feb 18, 2013) • Achieved: $351k in 94 days (352%) 42 www.ubiome.com
  • 43. • Rewards Promised • $5 shout-out • $25 t-shirt • Deliverables Promised • $79 GI Microbiome kit • $89 GI Microbiome Kit + t-shirt • $139 GI and Oral Microbiome kit + t-shirt • $148 2x GI Microbiome kit (1 for you, 1 for Africa) + t-shirt • $209 IBD: 3 GI kits for different time points • $235 IBD: 3 GI kits for different time points + web app for personal experiments + t-shirt • $335 GI, Mouth, Skin, Nose and Genital Microbiome kits + t-shirt • $1,337 5xkits to use at 5 different time points + personal guidance + t-shirt • $10,000 consultation with scientists, visit lab, all kits 43 www.ubiome.com
  • 44. • Marketing Materials • Comprehensive video describing product, physiology, etc. • Logos of selected press and news • Quotes from Key Opinion Leaders • Descriptions, content on microbes, body, how it works, pictures • Advisory board • Facebook (2,000+ likes), Twitter (5,400+ followers), YouTube (<5 videos), Website (welcome, how it works, order now, simple and effective website) • Mailing list, kit ordering 44 www.ubiome.com
  • 45. • About • Applied Integrin Sciences, Inc. discovers, develops and commercializes protein drug therapies for cancer treatments that reduce solid tumor growth and progression, and improve patient survival and quality of life. AIS is a socially responsible organization in drug development and targets the ovarian cancer indication for the intraperitoneal tumors as an orphan disease. • Campaign Hook • Involvement matters, impact will be huge, donation focused, 100% tax deductible with matching partners • Campaign Non-Financial Goals • Accelerate the availability of drug discovered at Norris Cancer Center that fights Ovarian, Breast & Prostate cancers. Need $200k to demonstrate “drugability” where drug discovery becomes drug development. With $500k, will have drug manufactured under FDA. With $1m will fulfill pre-requirements for investigational NDA with FDA, begin human clinical trials. VC and pharma expected to finance after this phase. • Campaign Financial Goals • Raised $86,000 of $200,000 goal | Launched 8/29/2013 ended 12/16/2013 (109d) • Tax deductible donation to cancer research 45 http://www.whenyouwish.com/project/boostcancersurvivalrates
  • 46. • Rewards Promised • $5 pen • $10 shout out, email updates • $20 ribbon signed by CEO • $50 two free move tickets • $50 coffee gift card ($25) • $50 in memory of dead, shout out • $100 in memory of loved one, name listed • $150 just because (nothing) • $250 your story featured on website w/ video/text • $500 phone conversation w CEO, story featured • $1,000 story of crowdfunding campaign, tips, stats, lessons learned • $1,001 lunch w CEO and story featured • $2,500 crwdfnd story PDF w tips, contacts, etc, your story, company logo as sponsor • $4,999 Dinner with scientists or CEO flies to you • $5,000 sponsor, workshop w creative team from AIS that developed the crowdfunding campaign, seminar on crowdfunding 46 http://www.whenyouwish.com/project/boostcancersurvivalrates
  • 47. • Marketing Materials • Executive summary • Company purpose, market & opportunity, management & advisors, product & technology, business model, financial, thesis • http://www.whenyouwish.com/upload/fa820770-7066-476e-b335-e77815928266.pdf • Fact sheet • http://www.whenyouwish.com/upload/dd7291db-8c10-4486-87e7-fd532485da5a.pdf • Development Funding Sought: Private equity (Series A), partnerships, grants for aggregate commitments of $22.0 million are sought; distributed in three success‐based milestone tranche investments to finance the company through Phase IIb clinical trials: 1) prepare for and file IND for Phase I/IIa human clinical trial ($3.0 million); 2) Conduct Phase I/Iia clinical trial/mfn. drug doses ($5.0 million); 3) conduct Phase IIb clinical trial ($14 million). • Presentation on company • Non-Confidential science presentation • http://www.whenyouwish.com/upload/9472f5f9-30bd-407d-ab10-0f915c71eca8.pdf 47
  • 48. • Start A Cure is a fundraising project for cancer research created by Malecare. • New York, NY 501(c)3 nonprofit • Raises funds and awareness, distributed 92% of funds (cite 16-65% for most foundations and gov’t agencies distribute) • John’s Hopkins research on prostate cancer treatment ($8k, met Dec ’13) • www.facebook.com/StartACure • Limited Twitter activity • Contact: Darryl Mitteldorf darryl@malecare.org 48 https://startacure.com/
  • 49. Name of Fund on .com website Organizer Raised # Pledgers Avg Pledge Goal % Goal development of bioactive anti-cancer drug Beth Israel Deaconess $ 30 3 $10 $ 45,000 0% Pre-clinical testing optimized prostate cancer NKT-'Gvax' vaccine Brigham & Women's $ 185 4 $46 $ 30,000 1% Live-cell prostate cancer diagnostic Cellanyx $ 27 3 $9 $ 13,500 0% Develop guide for how to diet after prostate cancer Dx Columbia University $ 20 2 $10 $ 50,000 0% Characterize pathways in prostate cancer Dana Farber Cancer Inst $ 50 1 $50 $ 50,000 0% Study to analyze prostate Dx, whites vs blacks John Hopkins professor $ 8,113 33 $246 $ 8,000 101% testosterone therapy for prostate cancer John Hopkins professor $ 2,900 14 $207 $ 25,000 12% PTEN biomarker for CT prostate cancer John Hopkins professor $ 105 3 $35 $ 50,000 0% Zytiga and Xtandi drug development John Hopkins professor $ 480 5 $96 $ 30,000 2% molecular raiotherapy for metastic prostate cancer John Hopkins professor $ 55 3 $18 $ 30,000 0% Heat ablation w HPV vaccine for anal precancers LA Gay & Lesbian Center R&D $ 20 2 $10 $ 50,000 0% genetic signature to identify men with risk of prostate cancer progression MD Anderson Cancer Center, TX $ 75 1 $75 $ 50,000 0% nanoparticle based thermal therapy and DD Medical Nanotechnologies, Inc. $ 440 9 $49 $ 10,000 4% Probing porstate cancer metastasis by circulating tumor cells UCLA $ 316 5 $63 $ 50,000 1% Using bacteria to cure prostate cancer University of California Irvine $ 15 1 $15 $ 50,000 0% drug to augment effectiveness of androgen deprivation University of Pittsburgh $ 220 5 $44 $ 8,000 3% Development of anti-insulin resistant drugs for obese University of Texas Anderson Cancer Center $ 26 2 $13 $ 45,000 0% Fighting prostate cancer w breast cancer drugs University of Toronoto $ 198 4 $50 $ 30,000 1% Cell-cell interaction in cancer development University of Washington $ 100 2 $50 $ 50,000 0% 49 Economics of cryotherapy for prostate cancer Winthrop University Hospital $ 10 1 $10 $ 35,000 0%
  • 50. JOHN HOPKINS' PROSTATE STUDY • Description of the study • Limited social media presence 50
  • 51. PHARMA SAFE (ROCKETHUB) • Drug abuse deterrent alarm and lock (device) • Rewards Promised • $10 Thank You • $25 label pin • $100 t-shirt, • Deliverables Promised • $250 actual device 51 http://www.rockethub.com/projects/35359-pharmasafe
  • 52. THE FLYING SYRINGE (ROCKETHUB) • West Nile Virus proof-of-concept idea to genetically modify mosquito populations • Rewards Promised • $5 Thank You • $10 Wristband • $25 email updates • $50 t-shirt, wrist band • $100 t-shirt, 3D molecule • $250 Skype call • $750 Skype call, virtual tour • $1,500 Skype call, daytime visit http://research.bergen.org/index.php/12-front-page-slider/ 52 60-provita-rockethubm
  • 53. NANOMEDICINE DRUGS FOR AIDS VIRUS • FAILED in 203: Only Raised $10 • http://www.rockethub.com/projects/11875-potential-nanomedicine- drug-for-aids-virus • Has rewards for up to $5K 53
  • 54. • Kids with rare or incurable diseases • Tax-deductible gift • Rewards Promised • $25 thank you • $100 “adopt a drug candidate” • $1,000 “adopt many drug candidates” for a classroom • $3,000 “adopt many drug candidates” for a classroom, wrist band, education website • $5,000 “adopt many drug candidates” for a classroom, wrist band, education website, 3 hours of Skype with scientist • $10k all above, scientist comes to school to present, + family dinner • $25k dinner with director 54
  • 55. SOME KEY CROWDFUNDING FOLKS • Krist Weling, partner at law firm McDermott WIll & Emergy (lawyer) • Thierry Merquiol, partner at France-based WiSeed (investor) • Souleymane-Jean Galadima, associate at WiSeed (investor) • Lorenzo Pellegrini, VC with Care Capital in Princeton, NJ (investor) • Barbara Nelson, consultant, Nelson Biomedical (consultant) • Gregory Simon, CEO, Poliwogg financial firms (investor) • Elaine Warburton, CEO and cofounder of QuantuMDx (funding) • Sylvain Costes, cofounder of Exogen (biotech) • Jon Tang, cofounder of Exogen (biotech) • David Miller, president of Biotech Stock Research in Seattle (research) 55
  • 56. TAKEAWAY: KEY POINTS • Helps to have network in place or expert support • Exposure on funding website can be crucial • Relevant content, news, interesting material (blog) • Comprehensive video • Many different donation amounts with different rewards (some real, some feel-good) • Heartstrings effect (bettering of society) • Rewards do not have to be deliverables • Meet the team, see the lab, view the science • Facebook and Twitter involvement to expand crowd but is not completely necessary 56
  • 57. ABOUT THE AUTHOR Rob Littlefield graduated from Columbia University in the City of New York with a Master of Science degree in Biomedical Engineering and Bucknell University with a Bachelor of Science degree in Biomedical Engineering. He currently is a medical device senior market research analyst for GlobalData Healthcare and lives in Waltham, MA with his wife, Lara, Founder and CEO of BWD inc. { contact@roblittlefield.com } 57