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How Genes Can Save Lives
1. Sudden Death and Sickle Cell Trait: How
Knowing Your Genes Can Save Your Life
Dale Lloyd II, No. 39.
(The Rice Football Webletter)
2006
After running 16 consecutive sprints
of 100 yards each, he collapsed.
He died the next day from acute
exertional rhabdomyolysis (ER)
associated with a genetic condition
called sickle cell trait.
Learning Set 4 : Lesson 1 : Slide 1
20. “Rules” that amino acids follow
• Charge
– Positive and negative charged amino
Red = positive charge (+)
acids attract each other K, R, H
– Amino acids with the same kind of charge
repel each other Yellow = negative charge
• Hydrophobicity (-)
– Hydrophilic amino acids attract water
– Hydrophobic amino acids repel water and
D, E
hydrophilic amino acids Green = hydrophobic
– Hydrophobic amino acids attract other
hydrophobic amino acids. A, V, L, I, P, M, F, W
• Cysteines Blue = hydrophilic
– Cysteines are a type of amino acid. When
two Cysteines are next to each other they G, S, T, N, Q, Y
attract and form a strong bond. These
strong bonds contribute to protein shape
White = cystine
formation. C
Learning Set 4 : Lesson 2 : Slide 12
23. Effects of Sickle Cell Mutation
DNA
order of
L T P E E K S L T P V E K S
amino acids
protein
shape
cell
function
Learning Set 4 : Lesson 2 : Slide 14
25. Frequency of Sickle Cell Causing Mutation
vs. Frequency of Malaria Causing Microbe
http://www.pbs.org/wgbh/evolution/library/01/2/l_012_02.html
Learning Set 4 : Lesson 4 : Slide 17
26. Analyzing RNA Using Gel Electrophoresis
Learning Set 4 : Lesson 5 : Slide 18
27. Who has lactose intolerance in Jason’s family?
Learning Set 4 : Lesson 5 : Slide 19