This study tested whether near-infrared (NIR) photonic analysis can detect inflammatory biomarkers like C-reactive protein (CRP) and B-type natriuretic peptide (BNP) in blood, and predict vulnerable plaque components such as cholesterol, collagen, elastin and macrophages in arterial tissue samples. The study used NIR spectroscopy to analyze human and rabbit aorta samples both in vitro and in vivo. Results showed NIR could accurately identify plaque structures and predict levels of inflammatory biomarkers, suggesting it may help detect dangerously unstable atherosclerotic plaques.