The workplace influences the safety, health, and productivity of workers at multiple levels. To protect and promote total worker health, smart hardware, and software tools have emerged for the identification, elimination, substitution, and control of occupational hazards. Wearable devices enable constant monitoring of individual workers and the environment, whereas connected worker solutions provide contextual information and decision support. Here, the recent trends in commercial workplace technologies to monitor and manage occupational risks, injuries, accidents, and diseases are reviewed. Workplace safety wearables for safe lifting, ergonomics, hazard identification, sleep monitoring, fatigue management, and heat and cold stress are discussed. Examples of workplace productivity wearables for asset tracking, augmented reality, gesture and motion control, brain wave sensing, and work stress management are given. Workplace health wearables designed for work-related musculoskeletal disorders, functional movement disorders, respiratory hazards, cardiovascular health, outdoor sun exposure, and continuous glucose monitoring are shown. Connected worker platforms are discussed with information about the architecture, system modules, intelligent operations, and industry applications. Predictive analytics provide contextual information about occupational safety risks, resource allocation, equipment failure, and predictive maintenance. Altogether, these examples highlight the ground-level benefits of real-time visibility about frontline workers, work environment, distributed assets, workforce efficiency, and safety compliance.
Trends in Workplace Wearable Technologies for Next Generation Occupational Sa...Iowa State University
Currently, there are niche applications for workplace wearables and connected worker solutions (herein referred to as workplace technologies) in almost every industry, be it in agriculture, construction, mining, production, healthcare, retail, warehousing, technology, transportation, or automotive industry. For example, workplace technologies are being used to detect awkward work postures, forceful exertions, vibrations, repetitive tasks, physical fatigue, mental acuity and stress, mood and emotions, safety compliance, and rest breaks.Our objective here is to provide a comprehensive review of commercial wearables and connected worker solutions for occupational safety, health, and productivity (Figure 1). Our intent is to cover workplace technologies that are already in use or have the potential for use at different worksites.
https://doi.org/10.1002/aisy.202100099
The International Journal of Engineering & Science is aimed at providing a platform for researchers, engineers, scientists, or educators to publish their original research results, to exchange new ideas, to disseminate information in innovative designs, engineering experiences and technological skills. It is also the Journal's objective to promote engineering and technology education. All papers submitted to the Journal will be blind peer-reviewed. Only original articles will be published.
Making India to a global healthcare hub, it is not only about bringing new technology but also we have to take care of the
existing technology. The healthcare hub is the leading factor for current economic growth of India. Human Factor Engineering
(HFE) plays a vital role in this field. In medical or healthcare, the field is named as Medical Human Factor Engineering (MHFE).
This paper discusses on how MHFE responsible for strengthen the Technology Management of Hospital, Hazards from device
failure and use related, Human Factors consideration in medical device use and case study on (Infusion Pumps) errors committed by
users in each clinical area. Now the challenging issue for HFE is to design a proper workspace to avoid human errors and the four
workspace design principles of Sanders & McCormick (1993) is also discussed. This paper deals with the Computer-aided-design
(CAD) systems and a failure mode and effects analysis (FMEA) technique with Simple Organizational Structure of HFE in designing the workspace.
Advancing the cybersecurity of the healthcare system with self- optimising an...Petar Radanliev
This article advances the knowledge on teaching and training new artificial intelligence algorithms, for securing, preparing,
and adapting the healthcare system to cope with future pandemics. The core objective is to develop a concept healthcare
system supported by autonomous artificial intelligence that can use edge health devices with real-time data. The article constructs two case scenarios for applying cybersecurity with autonomous artificial intelligence for (1) self-optimising predictive cyber risk analytics of failures in healthcare systems during a Disease X event (i.e., undefined future pandemic), and (2) self-adaptive forecasting of medical production and supply chain bottlenecks during future pandemics. To construct the two testing scenarios, the article uses the case of Covid-19 to synthesise data for the algorithms – i.e., for optimising and securing digital healthcare systems in anticipation of Disease X. The testing scenarios are built to tackle the logistical challenges and disruption of complex production and supply chains for vaccine distribution with optimisation algorithms.
A Neural Network Based Diagnostic System for Classification of Industrial Car...CSCJournals
Even with many years of research efforts, the occupational exposure limits of different risk factors for development of Musculoskeletal disorders (MSDs) have not yet been established. One of the main problems in setting such guidelines is the limited understanding of how different risk factors of MSDs interact in causing the injury, as the nature and mechanism of these disorders are relatively unknown phenomena. The task of an industrial ergonomist is complicated because the potential risk factors that may contribute to the onset of the MSDs interact in a complex way, and require an analyst to apply elaborate data measurement and collection techniques for a realistic job analysis. This makes it difficult to discriminate well between the jobs that place workers at high or low risk of above disorders. The main objective of this study was to to develop an artificial neural network based diagnostic system which can classify industrial jobs according to the potential risk for physiological stressors due to workplace design. Such a system could be useful in hazard analysis and injury prevention due to manual handling of loads in industrial environments. The results showed that the developed diagnostic system can successfully classify jobs into low and high risk categories of above musculoskeletal disorders based on carrying task characteristics. The Neural network based system developed gave the correct classification of the analysed industrial jobs with low and high risk. So, the system can be used as an expert system which, when properly trained, will classify carrying load by male and female workers into two categories of low risk and high risk work, based on the available characteristics factors.
Trends in Workplace Wearable Technologies for Next Generation Occupational Sa...Iowa State University
Currently, there are niche applications for workplace wearables and connected worker solutions (herein referred to as workplace technologies) in almost every industry, be it in agriculture, construction, mining, production, healthcare, retail, warehousing, technology, transportation, or automotive industry. For example, workplace technologies are being used to detect awkward work postures, forceful exertions, vibrations, repetitive tasks, physical fatigue, mental acuity and stress, mood and emotions, safety compliance, and rest breaks.Our objective here is to provide a comprehensive review of commercial wearables and connected worker solutions for occupational safety, health, and productivity (Figure 1). Our intent is to cover workplace technologies that are already in use or have the potential for use at different worksites.
https://doi.org/10.1002/aisy.202100099
The International Journal of Engineering & Science is aimed at providing a platform for researchers, engineers, scientists, or educators to publish their original research results, to exchange new ideas, to disseminate information in innovative designs, engineering experiences and technological skills. It is also the Journal's objective to promote engineering and technology education. All papers submitted to the Journal will be blind peer-reviewed. Only original articles will be published.
Making India to a global healthcare hub, it is not only about bringing new technology but also we have to take care of the
existing technology. The healthcare hub is the leading factor for current economic growth of India. Human Factor Engineering
(HFE) plays a vital role in this field. In medical or healthcare, the field is named as Medical Human Factor Engineering (MHFE).
This paper discusses on how MHFE responsible for strengthen the Technology Management of Hospital, Hazards from device
failure and use related, Human Factors consideration in medical device use and case study on (Infusion Pumps) errors committed by
users in each clinical area. Now the challenging issue for HFE is to design a proper workspace to avoid human errors and the four
workspace design principles of Sanders & McCormick (1993) is also discussed. This paper deals with the Computer-aided-design
(CAD) systems and a failure mode and effects analysis (FMEA) technique with Simple Organizational Structure of HFE in designing the workspace.
Advancing the cybersecurity of the healthcare system with self- optimising an...Petar Radanliev
This article advances the knowledge on teaching and training new artificial intelligence algorithms, for securing, preparing,
and adapting the healthcare system to cope with future pandemics. The core objective is to develop a concept healthcare
system supported by autonomous artificial intelligence that can use edge health devices with real-time data. The article constructs two case scenarios for applying cybersecurity with autonomous artificial intelligence for (1) self-optimising predictive cyber risk analytics of failures in healthcare systems during a Disease X event (i.e., undefined future pandemic), and (2) self-adaptive forecasting of medical production and supply chain bottlenecks during future pandemics. To construct the two testing scenarios, the article uses the case of Covid-19 to synthesise data for the algorithms – i.e., for optimising and securing digital healthcare systems in anticipation of Disease X. The testing scenarios are built to tackle the logistical challenges and disruption of complex production and supply chains for vaccine distribution with optimisation algorithms.
A Neural Network Based Diagnostic System for Classification of Industrial Car...CSCJournals
Even with many years of research efforts, the occupational exposure limits of different risk factors for development of Musculoskeletal disorders (MSDs) have not yet been established. One of the main problems in setting such guidelines is the limited understanding of how different risk factors of MSDs interact in causing the injury, as the nature and mechanism of these disorders are relatively unknown phenomena. The task of an industrial ergonomist is complicated because the potential risk factors that may contribute to the onset of the MSDs interact in a complex way, and require an analyst to apply elaborate data measurement and collection techniques for a realistic job analysis. This makes it difficult to discriminate well between the jobs that place workers at high or low risk of above disorders. The main objective of this study was to to develop an artificial neural network based diagnostic system which can classify industrial jobs according to the potential risk for physiological stressors due to workplace design. Such a system could be useful in hazard analysis and injury prevention due to manual handling of loads in industrial environments. The results showed that the developed diagnostic system can successfully classify jobs into low and high risk categories of above musculoskeletal disorders based on carrying task characteristics. The Neural network based system developed gave the correct classification of the analysed industrial jobs with low and high risk. So, the system can be used as an expert system which, when properly trained, will classify carrying load by male and female workers into two categories of low risk and high risk work, based on the available characteristics factors.
A Human-Centric Approach to Oil & Gas Industry SafetyCognizant
Wearables and other digital hardware can help minimize safety incidents. Monitoring biometrics and alerting workers before they become dangerously mentally or physically fatigued mitigates tiredness as a significant contributing factor in workplace accidents. Applying big data techniques to human behavior enables causal analysis to find the root causes of accidents.
Application of Proposed Equipment and Design of Occupational Safety and Healt...AJHSSR Journal
ABSTRACT: The abstract should summarize the content of the paper. Try to keep the abstract below 200
words. Do not make references nor display equations in the abstract. UD. X is a company engaged in the
production of supporting equipment for rice milling machines such as APC / grain cleaners, elevators / spoons,
skin breaking bodies, inflatable and suction blowers, groats, sieves and conveyors. This company uses machines
and equipment that have the possibility of causing accidents for its workers. Problems that often occur in this
company are work accidents where in the period (July 2020 - July 2021) there have been 52 work accidents,
caused by worker negligence in carrying out their work such as not using Personal Protective Equipment
(PPE/APD), lack of employee awareness regarding occupational safety and health, and the absence of a good
K3 system implementation. This study is to identify potential hazards that can occur using the Health Failure
Modes and Effects analysis (HFMEA) method and design an OHS system. The purpose of this study is to identify
potential hazards and design an OHS system. The results of the identification of potential hazards of work
accidents obtained 21 activities in the sub-process that have the potential to occur and 45 hazards that can
occur with the effect of injuries on several body parts, the hazard scoring matrix assessment with the highest
value of 12 and the lowest value of 2.33 potential hazards obtained hazard score 8 or higher, existing control
measure is No, detectability is Yes so the process stops at this point. A total of 12 potential hazards that get a
hazard score below 8, a single point weakness is worth No, the process stops here too. With the design of the K3
system as a solution for improving working conditions, including employee policies and regulations,
procurement of supporting equipment, K3 facilities, safety of machine operation
Keywords - HMFEA, K3, system plan, work accidents
Multi-Response Research Methodology for Ergonomic Design of Human-CNC Machine...IJERA Editor
This work is aimed at enriching a research theme, focused on exploiting the performance in a human-CNC
machine interface (HCMI) environment. A salient contribution of this research effort is focused on adopting the
concept of load cell for the system of human-performance measurement. The developed novel system is capable
of measuring cognitive and motor action responses simultaneously. The performance measurement system
designed for this work may be replicated for other fields where systems are operated through control panels and
also where responses of mentally retarded human-beings (or the human beings with the symptoms of Alzheimer
disease) are to be observed and evaluated.
Research relevance: The research methodology designed in this work can be directly applied to the practical
field to evaluate the performance in various human- panel operated system interface environments. This work
suggests that those responsible for the function and operation of CNC-machines workstations would have to
redesign the system to reduce injuries, as far as musculoskeletal and other related problems are concerned. The
present work can be quite useful for the system designers of tomorrow.
Workplace injuries continue to cost companies and their workers’ compensation insurers billions of dollars each year. Yet the combination of a new generation of industrial wearables, big data, and smart algorithms promises to change this picture for the better. Workers’ comp insurers and industrial organizations can benefit from partnering to drive these solutions into the workplace—in the process, decreasing claims, keeping industrial workers protected and productive, and bringing down costs across the board.
Efficient Safety Culture as Sustainable Development in Construction IndustryIJERA Editor
The paper focuses on precaution necessary to prevent avoidable accidents in the construction industries, important water development, building and roads construction in Nigeria. Moreover, appreciate the need for a safe working environment but also precaution necessary for hitch-free operation.
Use of ergonomics risk assessment tools on construction sitevivatechijri
Construction industry is one of the 7th industry with high risk exposure. The prevalent problem with construction industry in recent years is the health of construction workers. In residential construction sites workers daily activities includes Material handling, prolonged standing, bending, etc. this leads to musculoskeletal disorders (MSD’s). Some techniques are required to identify and control WRMSDs. Ergonomics involves the interaction between human, technology and organization in the purpose of optimizing well-being, health and performance. The aim of research is performing ergonomics risk assessment based on which ergonomics risk factors in building construction site is obtained and to give an overview of ergonomic risks at workplace by some of the observational methods that can be used for assessment. Through ergonomics risk assessment tools such as checklist (questionnaire), REBA (Rapid Entire Body Assessment) and QEC (Quick Exposure Check) data is collected. Risk rank order for activities are determined by RII (Relative Importance Index). Comparison of tool QEC and REBA is done and analysis is done in SPSS. The result showed that most workers are at higher and medium risk on residential construction site. Based on the analysis and findings task need to redesigned and reassessed so that it can be safely carried out. In an appendix we have included a brief presentation of these methods together with the work sheet (if available) and the reference source of the observational method.
The Healthcare Internet of Things: Rewards and Risksatlanticcouncil
In The Healthcare Internet of Things: Rewards and Risks, a collaboration between Intel Security and Atlantic Council's Cyber Statecraft Initiative at the Brent Scowcroft Center on International Security, the report's authors—Jason Healey, Neal Pollard, and Beau Woods—draw attention to the delicate balance between the promise of a new age of technology and society's ability to secure the technological and communications foundations of these innovative devices.
In this review, we focus on the hardware and software technologies used for the purpose of gastrointestinal tract monitoring in a safe and comfortable manner. We review the FDA guidelines for ingestible wireless telemetric medical devices, and the features incorporated in capsule systems such as microrobotics, closed-loop feedback, physiological sensing, nerve stimulation, sampling and delivery, panoramic imaging and rapid reading software. Both experimental and commercialized capsule systems with their sensors, devices, and circuits are discussed. Furthermore, the advances in biocompatible materials and batteries, edible electronics and alternative energy sources for ingestible capsule systems are presented. The clinical studies are reviewed to examine the safety and effectiveness of capsule procedures and the current challenges and outlook are summarized.
Dylan Miley*, Leonardo Bertoncello Machado*, Calvin Condo, Albert E. Jergens, Kyoung-Jin Yoon, Santosh Pandey, “Video Capsule Endoscopy and Ingestible Electronics: Emerging Trends in Sensors, Circuits, Materials, Telemetry, Optics, and Rapid Reading Software“, Advanced Devices & Instrumentation, (Science Partner Journal), Volume 2021, Article ID 9854040, 2021. https://spj.science.org/doi/10.34133/2021/9854040?permanently=true
https://doi.org/10.34133/2021/9854040
Antimicrobial resistance studies in low-cost microfluidic chipsIowa State University
By utilizing a low-cost engineering tool, we have created a microfluidic platform to study bacteria at the single cell level, allowing us to unlock insights into microbial physiology and genetics that would otherwise not be possible. The platform is composed of 3D devices made of adhesive tapes, an agarose membrane as the resting substrate, a temperature-controlled environmental chamber, and an autofocusing module. With this technology, we have been able to observe Escherichia coli morphological changes during ampicillin exposure and measure the minimum inhibitory concentration of the antibiotic. Additionally, we have been able to use CRISPR interference (CRISPRi) to evaluate gene regulation in a concentration gradient. Overall, our microfluidic platform provides a powerful, low-cost tool to uncover new genetic determinants of antibiotic susceptibility and assess the long-term effectiveness of antibiotics in bacterial cultures.
Adhesive Tape Microfluidics with an Autofocusing Module That Incorporates CRISPR Interference: Applications to Long-Term Bacterial Antibiotic Studies, Taejoon Kong, Nicholas Backes, Upender Kalwa, Christopher Legner, Gregory J. Phillips, and Santosh Pandey, ACS Sensors 2019 4 (10), 2638-2645
https://doi.org/10.1021/acssensors.9b01031
https://pubs.acs.org/doi/full/10.1021/acssensors.9b01031
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A Human-Centric Approach to Oil & Gas Industry SafetyCognizant
Wearables and other digital hardware can help minimize safety incidents. Monitoring biometrics and alerting workers before they become dangerously mentally or physically fatigued mitigates tiredness as a significant contributing factor in workplace accidents. Applying big data techniques to human behavior enables causal analysis to find the root causes of accidents.
Application of Proposed Equipment and Design of Occupational Safety and Healt...AJHSSR Journal
ABSTRACT: The abstract should summarize the content of the paper. Try to keep the abstract below 200
words. Do not make references nor display equations in the abstract. UD. X is a company engaged in the
production of supporting equipment for rice milling machines such as APC / grain cleaners, elevators / spoons,
skin breaking bodies, inflatable and suction blowers, groats, sieves and conveyors. This company uses machines
and equipment that have the possibility of causing accidents for its workers. Problems that often occur in this
company are work accidents where in the period (July 2020 - July 2021) there have been 52 work accidents,
caused by worker negligence in carrying out their work such as not using Personal Protective Equipment
(PPE/APD), lack of employee awareness regarding occupational safety and health, and the absence of a good
K3 system implementation. This study is to identify potential hazards that can occur using the Health Failure
Modes and Effects analysis (HFMEA) method and design an OHS system. The purpose of this study is to identify
potential hazards and design an OHS system. The results of the identification of potential hazards of work
accidents obtained 21 activities in the sub-process that have the potential to occur and 45 hazards that can
occur with the effect of injuries on several body parts, the hazard scoring matrix assessment with the highest
value of 12 and the lowest value of 2.33 potential hazards obtained hazard score 8 or higher, existing control
measure is No, detectability is Yes so the process stops at this point. A total of 12 potential hazards that get a
hazard score below 8, a single point weakness is worth No, the process stops here too. With the design of the K3
system as a solution for improving working conditions, including employee policies and regulations,
procurement of supporting equipment, K3 facilities, safety of machine operation
Keywords - HMFEA, K3, system plan, work accidents
Multi-Response Research Methodology for Ergonomic Design of Human-CNC Machine...IJERA Editor
This work is aimed at enriching a research theme, focused on exploiting the performance in a human-CNC
machine interface (HCMI) environment. A salient contribution of this research effort is focused on adopting the
concept of load cell for the system of human-performance measurement. The developed novel system is capable
of measuring cognitive and motor action responses simultaneously. The performance measurement system
designed for this work may be replicated for other fields where systems are operated through control panels and
also where responses of mentally retarded human-beings (or the human beings with the symptoms of Alzheimer
disease) are to be observed and evaluated.
Research relevance: The research methodology designed in this work can be directly applied to the practical
field to evaluate the performance in various human- panel operated system interface environments. This work
suggests that those responsible for the function and operation of CNC-machines workstations would have to
redesign the system to reduce injuries, as far as musculoskeletal and other related problems are concerned. The
present work can be quite useful for the system designers of tomorrow.
Workplace injuries continue to cost companies and their workers’ compensation insurers billions of dollars each year. Yet the combination of a new generation of industrial wearables, big data, and smart algorithms promises to change this picture for the better. Workers’ comp insurers and industrial organizations can benefit from partnering to drive these solutions into the workplace—in the process, decreasing claims, keeping industrial workers protected and productive, and bringing down costs across the board.
Efficient Safety Culture as Sustainable Development in Construction IndustryIJERA Editor
The paper focuses on precaution necessary to prevent avoidable accidents in the construction industries, important water development, building and roads construction in Nigeria. Moreover, appreciate the need for a safe working environment but also precaution necessary for hitch-free operation.
Use of ergonomics risk assessment tools on construction sitevivatechijri
Construction industry is one of the 7th industry with high risk exposure. The prevalent problem with construction industry in recent years is the health of construction workers. In residential construction sites workers daily activities includes Material handling, prolonged standing, bending, etc. this leads to musculoskeletal disorders (MSD’s). Some techniques are required to identify and control WRMSDs. Ergonomics involves the interaction between human, technology and organization in the purpose of optimizing well-being, health and performance. The aim of research is performing ergonomics risk assessment based on which ergonomics risk factors in building construction site is obtained and to give an overview of ergonomic risks at workplace by some of the observational methods that can be used for assessment. Through ergonomics risk assessment tools such as checklist (questionnaire), REBA (Rapid Entire Body Assessment) and QEC (Quick Exposure Check) data is collected. Risk rank order for activities are determined by RII (Relative Importance Index). Comparison of tool QEC and REBA is done and analysis is done in SPSS. The result showed that most workers are at higher and medium risk on residential construction site. Based on the analysis and findings task need to redesigned and reassessed so that it can be safely carried out. In an appendix we have included a brief presentation of these methods together with the work sheet (if available) and the reference source of the observational method.
The Healthcare Internet of Things: Rewards and Risksatlanticcouncil
In The Healthcare Internet of Things: Rewards and Risks, a collaboration between Intel Security and Atlantic Council's Cyber Statecraft Initiative at the Brent Scowcroft Center on International Security, the report's authors—Jason Healey, Neal Pollard, and Beau Woods—draw attention to the delicate balance between the promise of a new age of technology and society's ability to secure the technological and communications foundations of these innovative devices.
In this review, we focus on the hardware and software technologies used for the purpose of gastrointestinal tract monitoring in a safe and comfortable manner. We review the FDA guidelines for ingestible wireless telemetric medical devices, and the features incorporated in capsule systems such as microrobotics, closed-loop feedback, physiological sensing, nerve stimulation, sampling and delivery, panoramic imaging and rapid reading software. Both experimental and commercialized capsule systems with their sensors, devices, and circuits are discussed. Furthermore, the advances in biocompatible materials and batteries, edible electronics and alternative energy sources for ingestible capsule systems are presented. The clinical studies are reviewed to examine the safety and effectiveness of capsule procedures and the current challenges and outlook are summarized.
Dylan Miley*, Leonardo Bertoncello Machado*, Calvin Condo, Albert E. Jergens, Kyoung-Jin Yoon, Santosh Pandey, “Video Capsule Endoscopy and Ingestible Electronics: Emerging Trends in Sensors, Circuits, Materials, Telemetry, Optics, and Rapid Reading Software“, Advanced Devices & Instrumentation, (Science Partner Journal), Volume 2021, Article ID 9854040, 2021. https://spj.science.org/doi/10.34133/2021/9854040?permanently=true
https://doi.org/10.34133/2021/9854040
Antimicrobial resistance studies in low-cost microfluidic chipsIowa State University
By utilizing a low-cost engineering tool, we have created a microfluidic platform to study bacteria at the single cell level, allowing us to unlock insights into microbial physiology and genetics that would otherwise not be possible. The platform is composed of 3D devices made of adhesive tapes, an agarose membrane as the resting substrate, a temperature-controlled environmental chamber, and an autofocusing module. With this technology, we have been able to observe Escherichia coli morphological changes during ampicillin exposure and measure the minimum inhibitory concentration of the antibiotic. Additionally, we have been able to use CRISPR interference (CRISPRi) to evaluate gene regulation in a concentration gradient. Overall, our microfluidic platform provides a powerful, low-cost tool to uncover new genetic determinants of antibiotic susceptibility and assess the long-term effectiveness of antibiotics in bacterial cultures.
Adhesive Tape Microfluidics with an Autofocusing Module That Incorporates CRISPR Interference: Applications to Long-Term Bacterial Antibiotic Studies, Taejoon Kong, Nicholas Backes, Upender Kalwa, Christopher Legner, Gregory J. Phillips, and Santosh Pandey, ACS Sensors 2019 4 (10), 2638-2645
https://doi.org/10.1021/acssensors.9b01031
https://pubs.acs.org/doi/full/10.1021/acssensors.9b01031
Flexible chip for long-term antimicrobial resistance experimentsIowa State University
By creating a low-cost, three-dimensional microfluidic platform, we have improved our ability to study bacterial cells at the single cell level. This technology allows for prolonged culturing of bacteria in a controlled environment, as well as high resolution observation and imaging of cells. We have used this platform to examine morphological changes in Escherichia coli exposed to ampicillin and to quantify the minimum inhibitory concentration of the antibiotic. Additionally, we demonstrated the potential for precise gene regulation using CRISPR interference (CRISPRi) in a concentration gradient. Ultimately, this engineering tool should be useful for uncovering new genetic factors that influence antibiotic susceptibility and evaluating the long-term effectiveness of antibiotics.
Adhesive Tape Microfluidics with an Autofocusing Module That Incorporates CRISPR Interference: Applications to Long-Term Bacterial Antibiotic Studies, Taejoon Kong, Nicholas Backes, Upender Kalwa, Christopher Legner, Gregory J. Phillips, and Santosh Pandey, ACS Sensors 2019 4 (10), 2638-2645
https://doi.org/10.1021/acssensors.9b01031
https://pubs.acs.org/doi/full/10.1021/acssensors.9b01031
In this paper, we explore the use of microfluidic paper-based analytical devices (PADs) to study the behavior of Caenorhabditis elegans. We show how these devices can be fabricated on paper and plastic substrates, as well as how to load, visualize, and transfer single and multiple nematodes. We also demonstrate the use of anthelmintic drug, levamisole, to perform chemical testing on C. elegans. Furthermore, we provide a custom program that is able to recognize individual worms on the PADs in real-time and extract their locomotion parameters. This combination of PADs and the nematode tracking program creates a low-cost, easy-to-fabricate imaging and screening assay that is superior to standard agarose plates or polymeric microfluidic devices for non-microfluidic, nematode laboratories.
Zach Njus, Taejoon Kong, Upender Kalwa, Christopher Legner, Matthew Weinstein, Shawn Flanigan, Jenifer Saldanha, and Santosh Pandey, "Flexible and disposable paper- and plastic-based gel micropads for nematode handling, imaging, and chemical testing", APL Bioengineering 1, 016102 (2017)
https://doi.org/10.1063/1.5005829
https://aip.scitation.org/doi/10.1063/1.5005829
The resistance of parasites to existing drugs and the availability of better technology platforms has driven the discovery of new drugs. Microfluidic devices have been used to facilitate faster screening of compounds, controlled sampling/sorting of whole animals, and automated behavioral pattern recognition. In most cases, drug effects on small creatures (e.g., Caenorhabditis elegans) are measuredelegant by a single parameter such as worm velocity or stroke frequency. We present a multi-parameter extraction method to characterize modes of paralysis in C. elegans over a longer duration. This was done using a microfluidic device featuring real-time imaging, exposing worms to four anthelmintic drugs at EC75, where 75% of the worm population is affected. We monitored the worms' behavior with metrics such as curls per second, types of paralyzation, mode frequency, and number/duration of active/immobilization periods. Differences were observed in how the worms paralyzed in the various drug environments at equivalent concentrations. This study highlights the importance of assessing drug effects on small animals with multiple parameters, measured at regular intervals over a prolonged period, to accurately detect resistance and adaptability in chemical environments.
Roy Lycke, Archana Parashar, and Santosh Pandey, "Microfluidics-enabled method to identify modes of Caenorhabditis elegans paralysis in four anthelmintics", Biomicrofluidics 7, 064103 (2013).
https://doi.org/10.1063/1.4829777
https://aip.scitation.org/doi/10.1063/1.4829777
Melanoma is a particularly dangerous type of skin cancer and is hard to treat in its later stages. Therefore, early detection is key in reducing mortality rates. In order to assist dermatologists in doing this, computer-aided systems have been designed for desktop computers. However, there is a desire for the development of mobile, at-home diagnostics for melanoma risk assessment. Here, we introduce a smartphone application that captures images and extracts ABCD features to classify skin lesions as either malignant or benign. The algorithms used are adaptive to make the process light and user-friendly, as well as reliable in diagnosis. Images can be taken with the phone's camera or imported from public datasets. The entire process of taking the image, performing preprocessing, segmentation and classification is completed on an Android smartphone in a short time. Our application is evaluated on a dataset of 200 images, and achieved either comparable or better performance metrics than other methods. Additionally, it is easy-to-download and easy-to-navigate for the user, which is important for the widespread use of such diagnostics.
Kalwa, U.; Legner, C.; Kong, T.; Pandey, S. Skin Cancer Diagnostics with an All-Inclusive Smartphone Application. Symmetry 2019, 11, 790. https://doi.org/10.3390/sym11060790
https://www.mdpi.com/2073-8994/11/6/790
A CMOS biosensor with a folded floating-gate is created to detect charged biochemical molecules. It contains a FET, a control-gate and a sensing area. The floating-gate spans the whole device, allowing the sensing area to be placed on top of the FET, resulting in a decrease of the device's total area. The device is sensitive to the polarity and quantity of charged poly amino acids and could be used for electronic recognition of temporal and spatial migration of charges, such as in biological phenomena.
B. Chen, A. Parashar and S. Pandey, "Folded Floating-Gate CMOS Biosensor for the Detection of Charged Biochemical Molecules," IEEE Sensors Journal, vol. 11, no. 11, pp. 2906-2910, Nov. 2011, doi: 10.1109/JSEN.2011.2149514.
https://ieeexplore.ieee.org/document/5762313
We attempt to offer an innovative solution to the issues of long response times, large volumes of actuation fluid, and external control circuitry that have been associated with past approaches in creating switches in paper microfluidics. Our method consists of a device created from chromatography paper and featuring folds which, when selectively wetted with an actuation fluid, will either raise or lower the actuator's tip and thus engage or break the desired fluidic connections. As a result, response time is drastically reduced (2 seconds) and the volume of actuation fluid consumed is extremely small (4 microliters). We have tested this approach with six switch configurations, ranging from single-pole single-throw (normally OFF and normally ON) to single-pole double-throw (with single and double break). We further demonstrate its potential with a colorimetric assay involving six actuators in parallel, which can detect the presence of three analytes (glucose, protein, and nitrite) in artificial saliva. Finally, this work brings in the concept of origami to paper microfluidics, combining multiple-fold geometries for programmable switching of fluidic connections.
"A fast, reconfigurable flow switch for paper
microfluidics based on selective wetting of folded
paper actuator strips",
Lab on Chip, 2017, 17, 3621
A method to create smart and flexible switches for the regulation of liquid flow across multiple channels is essential in paper microfluidics. Prior approaches are hampered by long response times, high actuation fluid volumes, and external control circuitry. To diminish these problems, we designed a distinctive actuator device fashioned entirely from chromatography paper and featuring folds. The fold can be selectively wetted by an actuation fluid at either the crest or trough, resulting in the raising or lowering of the actuator's tip and thus bringing about the connection or severance of fluidic channels. This actuation principle reduces the response time to only two seconds and the amount of fluid used to merely four microliters. We have also added six switch arrangements which can be divided into single-pole single-throw (normally OFF and normally ON) and single-pole double-throw (with single and double break). The utilization of six actuators in a parallel system allowed us to construct an autonomous colorimetric assay for the detection of three analytes - glucose, protein, and nitrite - in artificial saliva. This study has brought the concept of origami to paper microfluidics, allowing the use of multiple-fold geometries for the programmable switching of fluidic connections.
Taejoon Kong et al, "A fast, reconfigurable flow switch for paper
microfluidics based on selective wetting of folded
paper actuator strips", Lab on Chip, 2017, 17, 3621
The transmembrane proteins known as ion channels play a role in controlling and preserving the ionic concentrations across the cell membrane. Modeling the flux of ions in and out of these channels on an atomic level is essential for understanding several neurological diseases and related pharmaceutical discoveries. Recent experimental research has provided information on the channel's physical structure which can be used to create realistic ion transport models. Different trajectories exist for the ions entering the channel, each having its own probability of occurrence. Variables that measure these trajectories are the translocation and return probabilities, average lifetime, and spectral density of the ion number fluctuations. Theoretical analysis of ion transport has been restricted to low-resolution continuum diffusion-based or kinetic-based models which do not consider important factors that have an effect on ionic conduction. This paper extends previous models by an electro-diffusion model which takes into account the effects of electric fields, energy barriers, and rate-limited association/dissociation of ions with surface charges present inside the channel. Derived from the analytical model are the survival probability and spectral density.
:Analytical Modeling of the Ion Number Fluctuations in Biological Ion Channels"
Journal of Nanoscience and Nanotechnology; Vol. 12, 2489–2495, 2012
Ion Channel Fluctuations in Transmemembrane Proteins within Cell MembranesIowa State University
The transmembrane proteins known as ion channels play a role in controlling and preserving the ionic concentrations across the cell membrane. Modeling the flux of ions in and out of these channels on an atomic level is essential for understanding several neurological diseases and related pharmaceutical discoveries. Recent experimental research has provided information on the channel's physical structure which can be used to create realistic ion transport models. Different trajectories exist for the ions entering the channel, each having its own probability of occurrence. Variables that measure these trajectories are the translocation and return probabilities, average lifetime, and spectral density of the ion number fluctuations. Theoretical analysis of ion transport has been restricted to low-resolution continuum diffusion-based or kinetic-based models which do not consider important factors that have an effect on ionic conduction. This paper extends previous models by an electro-diffusion model which takes into account the effects of electric fields, energy barriers, and rate-limited association/dissociation of ions with surface charges present inside the channel. Derived from the analytical model are the survival probability and spectral density.
This paper presents a remote monitoring tool for the objective measurement of behavioral indicators that can help in assessing the health and welfare of pigs in precision swine production. The multiparameter electronic sensor board can measure posture, gait, vocalization, and external temperature, and has been characterized through laboratory measurements and animal tests. Machine learning algorithms and decision support tools can be implemented to detect animal lameness, lethargy, pain, injury, and distress. The adoption of this technology could lead to more efficient management of farm animals, better targeting of sick animals, lower medical costs, and fewer antibiotics being used. Challenges and a road map for technology adoption are discussed, along with suggestions for future improvements.
Animals 2021, 11(9), 2665; https://doi.org/10.3390/ani11092665
We propose a remote monitoring device for measuring behavioral indicators like posture, gait, vocalization, and external temperature which can help in evaluating the health and welfare of pigs. The multiparameter electronic sensor board was tested in a laboratory and on animals. Machine learning algorithms and decision support tools can be used to detect lameness, lethargy, pain, injury, and distress. The roadmap for technology adoption, potential benefits, and further challenges are discussed. This technology could help in efficient management of farm animals, providing targeted attention to sick animals, saving medical costs, and reducing the use of antibiotics.
"Behavioral Monitoring Tool for Pig Farmers: Ear Tag Sensors,
Machine Intelligence, and Technology Adoption Roadmap",
Animals 2021, 11, 2665.
https://doi.org/10.3390/ani11092665
In this study, two sets of experiments were conducted in order to investigate the impact of static magnetic fields on the growth and ethanol production of Saccharomyces cerevisiae. The first experiment ran for 25 hours with a 2% dextrose loading rate, while the second ran for 30 hours with a 6% dextrose loading rate. The magnetic fields used were homogeneous and non-homogeneous, with strengths of 100 mT and 200 mT, respectively. The results showed that the homogenous magnetic field had no significant effect on cell growth, whilst the non-homogeneous field yielded an increase of approximately 8% in peak ethanol concentration compared to the control.
Deutmeyer, A. , Raman, R. , Murphy, P. and Pandey, S. (2011) Effect of magnetic field on the fermentation kinetics of Saccharomyces cerevisiae. Advances in Bioscience and Biotechnology, 2, 207-213.
doi: 10.4236/abb.2011.24031.
https://www.scirp.org/journal/paperinformation.aspx?paperid=6857
Magnetic field to improve fermentation kinetics for ethanol production Iowa State University
Two experiments were conducted to analyze the influence that magnetic fields have on cell growth and ethanol production during fermentation. The first experiment was conducted for 25 hours at a 2% dextrose loading rate with a homogeneous and non-homogeneous static magnetic field of 100 mT and 200 mT, respectively. The second experiment was conducted for 30 hours at a 6% dextrose loading rate with a non-homogeneous static magnetic field of 200 mT. The results indicated that homogeneous magnetic fields did not have a significant effect on the yeast cell growth. However, the non-homogeneous static magnetic field resulted in about 8% more peak ethanol concentration than the control for the 2% dextrose loading rate.
To evaluate the severity of SCN infections in the field, population densities of nematode eggs must be calculated. A method utilizing OptiPrep as a density gradient medium has been shown to provide more effective separation and recovery of extracted eggs compared to sucrose centrifugation. Furthermore, computerized processes have been established to facilitate the discernment and enumeration of eggs from processed samples. A high-resolution scanner was employed to capture static images of eggs and debris on filter papers, and a deep learning network was trained to distinguish and count the eggs from the debris. Additionally, a lensless imaging setup was established using standard components, and the egg samples were allowed to pass through a microfluidic flow chip created from double-sided adhesive tape. Holographic videos were then recorded of the eggs and debris as they moved through, which were reconstructed and processed by a custom software program to obtain the egg counts. The software programs' efficacy for egg counting was validated using soil samples obtained from two farms, and the results were compared to those obtained through manual counting.
Kalwa U, Legner C, Wlezien E, Tylka G, Pandey S (2019) New methods of removing debris and high-throughput counting of cyst nematode eggs extracted from field soil. PLOS ONE 14(10): e0223386.
https://doi.org/10.1371/journal.pone.0223386
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223386
To evaluate the level of infestation of the soybean cyst nematode (SCN), Heterodera glycines, in the field, egg population densities are determined from soil samples. Sucrose centrifugation is a common technique for separating debris from the extracted SCN eggs. We have developed a procedure, however, that employs OptiPrep as a density gradient medium, with improved extraction and recovery of the eggs compared to the sucrose centrifugation technique. Also, we have built computerized methods to automate the identification and counting of the nematode eggs from the processed samples. One approach uses a high-resolution scanner to capture static images of the eggs and debris on filter papers and a deep learning network is trained to detect and count the eggs. The second approach utilizes a lensless imaging setup with off-the-shelf components and the egg samples flow through a microfluidic flowchip. Holographic videos are taken of the passing eggs and debris, which are then reconstructed and processed by a custom software program to calculate egg counts. To evaluate the performance of the software programs, SCN-infested soils were collected from two farms and the results were compared with manual counts.
Kalwa U, Legner C, Wlezien E, Tylka G, Pandey S (2019), New methods of removing debris and high-throughput counting of cyst nematode eggs extracted from field soil. PLOS ONE 14(10): e0223386.
https://doi.org/10.1371/journal.pone.0223386
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223386
Effect of Static Magnetic Field on Parasitic Worms in MicroChipsIowa State University
This study uses the model organism, C. elegans, to investigate its sensitivity and response to static magnetic fields. Wild-type C. elegans are put into microfluidic channels and exposed to permanent magnets for five cycles of thirty-second time intervals at field strengths ranging from 5 milli Tesla to 120 milli Tesla. Recorded and analyzed with custom software, the results of the worm's movement - the average velocity, turning and curling percentage - were compared to control experiments. Surprisingly, the results did not show any significant difference, indicating that C. elegans may not be able to sense static magnetic fields at the range of field strengths tested.
Njus, Z. , Feldmann, D. , Brien, R. , Kong, T. , Kalwa, U. and Pandey, S. (2015) Characterizing the Effect of Static Magnetic Fields on C. elegans Using Microfluidics. Advances in Bioscience and Biotechnology, 6, 583-591.
doi: 10.4236/abb.2015.69061.
https://www.scirp.org/journal/paperinformation.aspx?paperid=59434
The integration of physical and chemical sensing mechanisms found in nature has been harnessed to enable the development of wearable devices that can track the biochemical and physiological signals of the human body. Numerous consumer electronics have been developed to measure activity, posture, heart rate, respiration rate, and blood oxygen level. Sweat sampling provides a source of biomarkers that is accessible in a continuous, on-the-go, and non-invasive way, allowing for unique developments in wearable sweat sensing. This review focuses on recent trends in material science, device development, sensing mechanisms, power generation, and data management related to these devices. Additionally, exemplary wearable sweat sensors and commercialization efforts in this area are discussed, with an emphasis on the multifunctional sensing platforms that integrate data from both physical and biochemical sweat sensors.
Recent developments in wearable physical sensors have enabled the development of a number of consumer electronics products which measure parameters related to activity, posture, heart rate, respiration rate, and blood oxygen level. However, progress in the development of wearable chemical sensors has been slower due to the inherent challenges in retrieving and processing bodily fluids. Sweat is a valuable source of biomarkers which can be accessed continuously, on-the-go, and non-invasively. This review provides an overview of recent trends in the area of wearable sweat sensing, looking at topics such as material science, device development, sensing mechanisms, power generation, and data management. Examples of wearable sweat sensors published in recent years, as well as commercialization efforts in this field are also presented. The review highlights the trends in multifunctional sensing platforms which incorporate flexible electronics to integrate data from both physical and biochemical sensors.
06-04-2024 - NYC Tech Week - Discussion on Vector Databases, Unstructured Data and AI
Discussion on Vector Databases, Unstructured Data and AI
https://www.meetup.com/unstructured-data-meetup-new-york/
This meetup is for people working in unstructured data. Speakers will come present about related topics such as vector databases, LLMs, and managing data at scale. The intended audience of this group includes roles like machine learning engineers, data scientists, data engineers, software engineers, and PMs.This meetup was formerly Milvus Meetup, and is sponsored by Zilliz maintainers of Milvus.
06-04-2024 - NYC Tech Week - Discussion on Vector Databases, Unstructured Data and AI
Round table discussion of vector databases, unstructured data, ai, big data, real-time, robots and Milvus.
A lively discussion with NJ Gen AI Meetup Lead, Prasad and Procure.FYI's Co-Found
Techniques to optimize the pagerank algorithm usually fall in two categories. One is to try reducing the work per iteration, and the other is to try reducing the number of iterations. These goals are often at odds with one another. Skipping computation on vertices which have already converged has the potential to save iteration time. Skipping in-identical vertices, with the same in-links, helps reduce duplicate computations and thus could help reduce iteration time. Road networks often have chains which can be short-circuited before pagerank computation to improve performance. Final ranks of chain nodes can be easily calculated. This could reduce both the iteration time, and the number of iterations. If a graph has no dangling nodes, pagerank of each strongly connected component can be computed in topological order. This could help reduce the iteration time, no. of iterations, and also enable multi-iteration concurrency in pagerank computation. The combination of all of the above methods is the STICD algorithm. [sticd] For dynamic graphs, unchanged components whose ranks are unaffected can be skipped altogether.
The Building Blocks of QuestDB, a Time Series Databasejavier ramirez
Talk Delivered at Valencia Codes Meetup 2024-06.
Traditionally, databases have treated timestamps just as another data type. However, when performing real-time analytics, timestamps should be first class citizens and we need rich time semantics to get the most out of our data. We also need to deal with ever growing datasets while keeping performant, which is as fun as it sounds.
It is no wonder time-series databases are now more popular than ever before. Join me in this session to learn about the internal architecture and building blocks of QuestDB, an open source time-series database designed for speed. We will also review a history of some of the changes we have gone over the past two years to deal with late and unordered data, non-blocking writes, read-replicas, or faster batch ingestion.
Levelwise PageRank with Loop-Based Dead End Handling Strategy : SHORT REPORT ...Subhajit Sahu
Abstract — Levelwise PageRank is an alternative method of PageRank computation which decomposes the input graph into a directed acyclic block-graph of strongly connected components, and processes them in topological order, one level at a time. This enables calculation for ranks in a distributed fashion without per-iteration communication, unlike the standard method where all vertices are processed in each iteration. It however comes with a precondition of the absence of dead ends in the input graph. Here, the native non-distributed performance of Levelwise PageRank was compared against Monolithic PageRank on a CPU as well as a GPU. To ensure a fair comparison, Monolithic PageRank was also performed on a graph where vertices were split by components. Results indicate that Levelwise PageRank is about as fast as Monolithic PageRank on the CPU, but quite a bit slower on the GPU. Slowdown on the GPU is likely caused by a large submission of small workloads, and expected to be non-issue when the computation is performed on massive graphs.
Adjusting primitives for graph : SHORT REPORT / NOTESSubhajit Sahu
Graph algorithms, like PageRank Compressed Sparse Row (CSR) is an adjacency-list based graph representation that is
Multiply with different modes (map)
1. Performance of sequential execution based vs OpenMP based vector multiply.
2. Comparing various launch configs for CUDA based vector multiply.
Sum with different storage types (reduce)
1. Performance of vector element sum using float vs bfloat16 as the storage type.
Sum with different modes (reduce)
1. Performance of sequential execution based vs OpenMP based vector element sum.
2. Performance of memcpy vs in-place based CUDA based vector element sum.
3. Comparing various launch configs for CUDA based vector element sum (memcpy).
4. Comparing various launch configs for CUDA based vector element sum (in-place).
Sum with in-place strategies of CUDA mode (reduce)
1. Comparing various launch configs for CUDA based vector element sum (in-place).
Learn SQL from basic queries to Advance queriesmanishkhaire30
Dive into the world of data analysis with our comprehensive guide on mastering SQL! This presentation offers a practical approach to learning SQL, focusing on real-world applications and hands-on practice. Whether you're a beginner or looking to sharpen your skills, this guide provides the tools you need to extract, analyze, and interpret data effectively.
Key Highlights:
Foundations of SQL: Understand the basics of SQL, including data retrieval, filtering, and aggregation.
Advanced Queries: Learn to craft complex queries to uncover deep insights from your data.
Data Trends and Patterns: Discover how to identify and interpret trends and patterns in your datasets.
Practical Examples: Follow step-by-step examples to apply SQL techniques in real-world scenarios.
Actionable Insights: Gain the skills to derive actionable insights that drive informed decision-making.
Join us on this journey to enhance your data analysis capabilities and unlock the full potential of SQL. Perfect for data enthusiasts, analysts, and anyone eager to harness the power of data!
#DataAnalysis #SQL #LearningSQL #DataInsights #DataScience #Analytics
Unleashing the Power of Data_ Choosing a Trusted Analytics Platform.pdfEnterprise Wired
In this guide, we'll explore the key considerations and features to look for when choosing a Trusted analytics platform that meets your organization's needs and delivers actionable intelligence you can trust.
Chatty Kathy - UNC Bootcamp Final Project Presentation - Final Version - 5.23...John Andrews
SlideShare Description for "Chatty Kathy - UNC Bootcamp Final Project Presentation"
Title: Chatty Kathy: Enhancing Physical Activity Among Older Adults
Description:
Discover how Chatty Kathy, an innovative project developed at the UNC Bootcamp, aims to tackle the challenge of low physical activity among older adults. Our AI-driven solution uses peer interaction to boost and sustain exercise levels, significantly improving health outcomes. This presentation covers our problem statement, the rationale behind Chatty Kathy, synthetic data and persona creation, model performance metrics, a visual demonstration of the project, and potential future developments. Join us for an insightful Q&A session to explore the potential of this groundbreaking project.
Project Team: Jay Requarth, Jana Avery, John Andrews, Dr. Dick Davis II, Nee Buntoum, Nam Yeongjin & Mat Nicholas
Adjusting OpenMP PageRank : SHORT REPORT / NOTESSubhajit Sahu
For massive graphs that fit in RAM, but not in GPU memory, it is possible to take
advantage of a shared memory system with multiple CPUs, each with multiple cores, to
accelerate pagerank computation. If the NUMA architecture of the system is properly taken
into account with good vertex partitioning, the speedup can be significant. To take steps in
this direction, experiments are conducted to implement pagerank in OpenMP using two
different approaches, uniform and hybrid. The uniform approach runs all primitives required
for pagerank in OpenMP mode (with multiple threads). On the other hand, the hybrid
approach runs certain primitives in sequential mode (i.e., sumAt, multiply).