2. Incidence
• One of most common malignancy world wide
• Annual 1 million case
• M:F 4:1
• Mean Age 56 ± 13
• Associated with
– cirrhosis 81%
– No cirrhosis 19%
3. • Etiology
– Cirrhosis from any cause
– Hep B&C chronic infection
– Chronic ethanol consumption
– NASH/NAFLD
– Mycotoxin- Alfatoxin B1
4. • Unusual
– Pri biliay cirrhosis
– Hemachromatosis
– Α1 Antitrypsin def
– Glycogen storage disorder
– Wilson disease