This document summarizes the progress of the author's Ph.D. research from June 2021 to January 2023. The goal of the research is to examine the impacts of Covid-19 on hospitalized patients in Duhok province, Kurdistan region, by analyzing how SARS-CoV-2 induces cytokine storms and oxidative stress that increase fatality rates. It also evaluates the effects of multiple drug therapies on hospitalized patients. The study will analyze whole genome sequencing and phylogeny of SARS-CoV-2 cases, examine ACE2 expression rates in different age groups and genders and their link to infection severity, and investigate the interaction between the SARS-CoV-2 spike protein and ACE2-expressing cells

1. Molecular Immunopatological Study of ACE2 Expression and
Polymorphism in COVID-19 Patients in Duhok City ,Kurdistan Region of
Iraq

2. • In this report I have summarized my Ph.D. research progress from
June 2021 to January 2023. This time period corresponds to part of
the second and third year of my Ph.D. candidacy.
• As stated in my proposal, the goal of my Ph.D. research is to clarify
the impacts of Covid-19 in hospitalized patients in Duhok province-
Kurdistan region by illustrating and finding out the toxic impacts of
SARS-CoV-2 in infected patients that induces cytokine storm and
evokes oxidative stress, which therefore increase fatality rate of the
aforementioned patients. Furthermore the evaluation of multi-
therapy (poly- pharmacy) impacts in the hospitalized patients.

3. Why this study ?
• Whole genome sequence and phylogenetic
analysis of SARS-CoV-2 from the cases of covid-19
and ACE2 Polymorphisms.
• The proposal will examine the assessment of the
expression rates of ACE2 in different age groups
and gender and their correlation with the severity
of infection.
• Investigation of Interaction and Inhibition
between the Spike Protein RBD of SARS- CoV-2
and ACE2-Expressing Cells.