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69-Shrader

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69-Shrader

  1. 1. Case Number: 69 A Case of Canine Glaucoma Permission granted only for viewing on SEVPAC website 1Stephanie Shrader, 1Jennifer (Jey) Koehler, 2Roxanne Rodriguez, 2Phillip Moore 1Department of Pathobiology and 2Department of Clinical Sciences Auburn University, College of Veterinary Medicine (AUCVM)
  2. 2.  4-year-old, castrated male, Labrador retriever mix  One-week history of blepharospasm (OD)  Intraocular pressure (IOP): 50-mmHg  Normal: 12-mmHg to 25-mmHg  Placed on triple antibiotic ophthalmic ointment and referred to the AUCVM SIGNALMENT AND HISTORY Permission granted only for viewing on SEVPAC website
  3. 3.  Right eye: blepharospasm, buphthalmia, aqueous flare, corneal edema, posterior synechiae, vascular attenuation, cupped optic disc, IOP of 47-mmHg  Left eye: reportedly unremarkable  CBC and chemistry values: WNL  Treated with latanoprost and dorzolamide (decrease IOP) and tramadol (pain relief) Owners opted for enucleation of the right globe OPHTHALMIC EXAMINATION Permission granted only for viewing on SEVPAC website
  4. 4. CORNEAL EDEMA 100-um Permission granted only for viewing on SEVPAC website 20-um H&E H&E
  5. 5. CLOSED IRIDOCORNEAL ANGLE Permission granted only for viewing on SEVPAC website 100-um 500-um H&E H&E
  6. 6. POSTERIOR SYNECHIAE Permission granted only for viewing on SEVPAC website 100-um 20-um H&E H&E
  7. 7. Permission granted only for viewing on SEVPAC website 20-um RETINAL DEGENERATION Nerve fiber layer Inner plexiform layer Inner nuclear layer Outer plexiform layer Outer nuclear layer Rods and conesH&E H&E H&E 20-um 20-um
  8. 8. Right globe: Lymphohistiocytic endophthalmitis, multifocal, scant, subacute with iridocorneal angle closure, posterior synechiae, retinal degeneration and atrophy, and corneal stromal edema MORPHOLOGIC DIAGNOSIS Permission granted only for viewing on SEVPAC website
  9. 9. http://blogs.edweek.org/edweek/the_startup_blog/2014/02/but_wait_theres_more_building_a_solution_to_users_actual_problems_edthena.html Permission granted only for viewing on SEVPAC website
  10. 10. DESCEMET’S MEMBRANE Permission granted only for viewing on SEVPAC website 20-um H&E PAS
  11. 11. Right globe: Goniodysgenesis with minimal lymphohistiocytic endophthalmitis, iridocorneal angle closure, posterior synechiae, retinal degeneration and atrophy, and corneal stromal edema FINAL MORPHOLOGIC DIAGNOSIS Permission granted only for viewing on SEVPAC website
  12. 12.  Congenital anomaly of the iridocorneal angle  Abnormal intraocular fluid egress1  Risk factor for development of primary glaucoma  Associated with abnormal development of:  Pectinate ligament  Trabecular meshwork  Ciliary cleft  Absence of concurrent ocular or systemic disease2 GONIODYSGENESIS Permission granted only for viewing on SEVPAC website
  13. 13.  Hallmark histologic feature:  Solid sheet of iridal tissue extending to the distorted terminus of Descemet’s membrane3  Although congenital, clinical signs in dogs manifest at 4-8 years of age4,5  Following diagnosis in one eye, the contralateral eye may also develop glaucoma  Clinical course can range from days to years GONIODYSGENESIS Permission granted only for viewing on SEVPAC website
  14. 14. 1. R. Sampaolesi, et al. Goniodysgenesis or Late Congenital Glaucoma. Pigmentary Glaucoma. In: The Glaucomas. Vol. 1, Pediatric Glaucomas. Berlin: Springer. 311-66. 2009. 2. "Read-Only Case Details Reviewed: May 2012." The Joint Pathology Center, n.d. Web. 14 Apr. 2015. <http://www.askjpc.org/vspo/show_page.php?id=713>. 3. R. Dubielzig, et al. Veterinary Ocular Pathology: A Comparative Review. Edinburgh: Saunders/Elsevier. 45-46. 2010. 4. K Gelatt. The canine glaucomas. In: Veterinary Ophthalmology, 3rd Ed. (ed. Gelatt KN) Lea & Febiger, Philadelphia, 701–754. 1999. 5. C Reilly, et al. Canine goniodysgenesis-related glaucoma: a morphologic review of 100 cases looking at inflammation and pigment dispersion. Veterinary Ophthalmology. 9(6):253-254. 2006. REFERENCES Permission granted only for viewing on SEVPAC website
  15. 15. QUESTIONS?? http://galleryhip.com/tumblr-brown-eyes-collage.html Permission granted only for viewing on SEVPAC website

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