This chapter discusses addictions and substance abuse. The objectives are to explain how substance abuse affects health, describe gambling addictions and drug use on college campuses, identify types of substance use disorders, classify common drugs of abuse, and outline principles of drug abuse treatment. Risky behaviors that correlate with substance abuse are discussed such as alcohol use, smoking, low physical activity, and poor diet. Gambling disorder affects more men than women and is more common than alcohol dependence. Methods of drug intake, toxicity levels, and effects of various substances like caffeine, over-the-counter medications, and illicit drugs are outlined.