2. What is Sepsis
In a NORMAL response to an
infection, the inflammatory and
coagulation response is localized to
the infection site as the immune
system attacks the pathogen,
eliminating it from the body.
3. A Worldwide problem
Sepsis is a major, world-wide health care problem
● Affecting an estimated 30 million adults and children each
year resulting in potentially six million deaths annually
● Accounts for ~20 percent of U.S. hospital admissions but is
a factor in over 50 //percent of U.S. hospital deaths
● Is the leading cause of U.S. hospital readmissions (20
percent)
Although mortality has decreased in the last decade, it remains
over 25 percent → 1 in 4
4. In Sepsis....
The inflammatory and coagulation response is rapid and
widespread, causing a dysregulated response
The body’s reaction to the pathogen may overwhelm all of
the body’s systems
Immune systems that are too strong or too weak are unable
to respond effectively to pathogen invasion
5. Causes of Sepsis
● Bacterial infections are the
most common
● Fungal, parasitic or viral
infections can also cause
sepsis
● The infection can originate
from anywhere in the body and
can cause organ damage to
any system of the body
8. Treatment -
● Antibiotics - broad spectrum antibiotics are used. Once
blood tests are back we can give antibiotics tailored to
that infection.
● Intravenous fluid
● Vasopressor - they are given to help increase blood
pressure.
9. Prognosis
● Sepsis may cause abnormal blood clotting that results
in small clots or burst blood vessels that damage or
destroy tissues. Most people recover from mild sepsis,
but the mortality rate for septic shock is about 40%.
Also, an episode of severe sepsis places you at higher
risk of future infections.
