When the body experiences a cut, white blood cells called leukocytes are transported to the site of injury to fight infection. P-selectin proteins in blood vessels help leukocytes roll along the inner wall to the injured location. Once there, chemokines and proteoglycans provide directions and details to the leukocytes about how to respond to the inflammation. The leukocytes then migrate through the blood vessel wall into the injured tissue to begin the healing process and defend against foreign agents.

1. Cell Video What happens when a person gets a cut and how does the body react to the incident.

2. Are found within your arteries and veins Defend your body against infecting organisms and foreign agents Respond to the site of inflammation P selectin play an important role because they roll the white blood cells to the site of inflammation Help them role because existing sites are broken when the cut occurs and new ones are formed CONCLUSIONS FOR STUDENTS: White blood cells are taken where the site of inflammation(where the person has the cut) took place to fight the bacteria Leukocytes and P selectin

3. (OUTER LAYER) Lipid rafts, Cholesterols, Chemokine, Proteoglycan Organization center assembling molecules, membrane fluidity, membrane trafficking, neurotransmission(nerve impulses), and receptor trafficking Cholesterols are a protective agent in the skin and a detoxifier in the bloodstream Chemokine provide directions to tell the leucocytes where to go exactly to site of inflammation Proteoglycan give detail to the chemokine how to deal with the site of inflammation, which then are attached to the receptors to give the signal to the white blood cells CONCLUSIONS FOR STUDENTS:The way that the white blood cells know where to go is given by the chemokine and proteoglycan and the lipid rafts make fluids to patch up the infection along with the cholesterol

4. Inner layer is critical for the transmission Spectrin Tetramer plays an important role in maintenance of plasma membrane integrity and cytoskeleton structure(boss of the inner layer) Actin filament forms microfilaments, give mechanical support to cells, and hardware cytoplasm, which then are added with monomers by polymerization Severing protein attach themselves to the filaments which then cause the actin filaments to be unstable, which lead to the formation of short fragments causing depolymerzation and rise to new filaments CONCLUSIONS FOR STUDENTS: In the inner layer the spectrin is the corporation and runs everything, and the actin filaments are the second chain command (INNER LAYER) Spectrin Tetramer, Actin filament, Severing Protein

5. Cytoskeleton make microtubules, created by polymerization in tubiolin dimmers, which cause as a road/ highway the + ends extend to the plasma membrane Vesicle transports and stores substances which are lead by motor proteins linking vesicles and microtubleous Mitochondria change shape and interaction is dictated with microtubleous All microtubleous originate from centrosome ( which contain 2 centriole) and located by cell nucleus CONCLUSIONS FOR STUDENTS: The highways of microtubleous all come from the centrosome which help movement around the inner layer of the cell (INNER LAYER CONT.) Cytoskeleton, Vesicle, Mitochondria

6. Pores in the nuclear envelope allow particles containing mRNA and proteins into the cytosome( where free ribosome's translate mRNA molecules into proteins) which some will reside in the cystsome while others will be imported into the mitochondria or other organelles Free ribosomes then duct into translocatiors which are located in the surface of the E.R. which pass proteins into the E.R. and the ones that are too big to pass through are stuck outside the surface of the E.R. Proteins are transported from the E.R. to the Golgi Apparatus by vesicles traveling on the microtubleous CONCLUSIONS FOR STUDENTS: Pores allow nutrients and mRNA to pass and make protein for the Golgi Apparatus and the E.R. in exchange for the services they do for the cell Pores, Endoplasmic Reticulum

7. Proteins are then turned into glycosidic after entering the Golgi Apparatus Fully glycosidic proteins are transported for Golgi Apparatus to plasma membrane When a vesicles fuses with the plasma membrane it releases proteins and the ones embedded are diffused in cell membrane CONCLUSIONS FOR STUDENTS: Golgi Apparatus is the last step for the proteins to become glycosidic Golgi Apparatus

8. Chemokin in the site of inflammation send signal to the receptor which causes change in the inner layer and sub unit of the G unit Activation of sub unit triggers protein activation which causes intergins inside lipid rafts Which causes the intergrins to come in contact with the outer layer and interaction with I-Cam protein which immobilizes the leukocytes to the site of inflammation which causes the body to start working on covering the site of inflammation which causes the leukocyte to migrate through blood vessel wall into the inflamed tissue Conclusion