Shark liver oil (SLO) is made from the livers of sharks, especially Centrophorus squamosas, Cetorhinus maximus, and Squalus acanthias.

1. What is Shark
Liver Oil, and how
does it work?

2. What is Shark Liver Oil, and how does it
work?
Shark liver oil (SLO) is made from the livers
of sharks, especially Centrophorus
squamosus, Cetorhinus maximus, and
Squalus acanthias, or deep-sea shark,
basking shark, and dogfish shark.
It uses in Scandinavian traditional medicine
for a long time to cure wounds, cancer,
heart disease, and infertility, among other
things.
It’s now available as a dietary supplement
that claims to provide the same health
benefits.
SLO’s high alkylglycerol (AKG), squalene,
and omega-3 polyunsaturated fatty acid
(PUFA) content link to a variety of health
advantages, according to research.

3. The oil has a strong scent and flavor and is
dark yellow to brown. SLO may find in
liquid or pill form, as well as in skin creams
and lip balms.
Advantages and Applications
The alleged health advantages of SLO
assume due to certain chemicals in the oil,
including AKG, squalene, and omega-3
PUFAs.
Here are some of SLO’s most common
applications and advantages, all of which
scientific validates.
It may have Anticancer Qualities
One of the most often advertised
advantages of SLO is its cancer-fighting
ability. Which is predicate sharks’
extraordinarily low cancer incidence and

4. backed up by the oil’s high AKG and
squalene concentration.
AKG is a kind of fat found in blood-forming
organs including the spleen and liver. It’s
prevalent in breast milk and red blood
cells, in addition to SLO.
AKG seems to have anti-tumor potential in
test tubes and animals via activating
macrophages and inhibiting angiogenesis.
Macrophages are a kind of white blood cell
that digests damaged cells, including
malignant cells. As well as other
substances, and are important in anti-
tumor defense.
Meanwhile, it has an anti-angiogenesis
effect, which means it prevents new blood
vessels from forming, which might feed

5. cancer cells. As a result, it aids in the
slowing of tumor development and
dissemination.
In addition, dogfish sharks are thought the
greatest source of squalene, a chemical
name after the genus Squalus.
Squalene is thought to minimize the
inflammation generates by anticancer
medications, making it a good supplement
to chemotherapy.
Keep in mind, however, that human
research still requires.
It may help your immune system
SLO utilize by fishermen since ancient times
because of its ability to boost immunity.

6. AKGs in the oil, in addition to stimulating
macrophages, increase antibody formation
and improve the function of Fc-receptors.
Which are proteins that contribute to the
immune system’s protective role.
Antibody levels rose dramatically,
inflammation decreases marginally, and the
beginning of problems minimize during a
4-week trial in 40 older persons given 500
mg of pure AKG capsules twice daily before
and after surgery.
When coupled with surfactants, squalene,
on the other hand, seems to serve as an
enhancer that boosts the efficiency of
vaccinations. Surfactants are chemicals that
enable the solubilization or stabilization of
two molecules that would otherwise not
mix.

7. Squalene’s immunostimulating action,
which boosts antibody formation and
higher immunological response, is most
likely to blame.
Finally, because of their anti-inflammatory
properties, PUFAs such as omega-3s
contained in SLO may alter your body’s
immunological function.
It may help your heart
SLO’s influence on heart health is another
well-known advantage. Squalene, on the
other hand, has conflicting scientific data.
The squalene has anti-atherosclerotic
properties, which means it reduces or slows
the accumulation of plaque in your arteries.
Which is a risk factor for high blood
pressure and stroke.

8. Squalene is also a precursor to cholesterol
creation, and it is thought to build up in the
liver, lowering cholesterol and triglyceride
synthesis.
Furthermore, 11-week research found a
rise in HDL (good) cholesterol levels in rats
given 0.45 grams per pound (1 gram per
kg) of squalene.
Furthermore, omega-3 PUFAs
including oil have been shown to lower the
risk of heart disease.
Squalene, on the other hand, seems to
raise total cholesterol and triglyceride
levels, according to new research.
In one research, animals given a 0.05
percent and 0.5 percent squalene-
supplemented food saw total cholesterol

9. levels rise by 32 percent and 35 percent,
respectively. Blood triglyceride levels
followed a similar pattern.
A 4-week trial in 13 individuals found high
dosages of SLO. Which comprised 3.6
grams of AKG and squalene as well as 750
mg of omega-3 PUFAs, raised overall
cholesterol levels by 23%.
Researchers discovered that the anti-
inflammatory benefits of omega-3 don’t
present with such high concentrations of
AKG and squalene, and they concluded
that the anti-inflammatory effects of
omega-3 don’t manifest with such high
doses of AKG and squalene. When healthy
persons were given 15 grams of SLO every
day for four weeks, they had similar
outcomes.

10. Other Possible Advantages
Additional health advantages may attribute
to the AKGs, squalene, and omega-3
PUFAs found in SLO:
Fertility may be Improved: AKGs in SLO
have been shown in animal experiments to
increase sperm motility and speed.
It has the Potential to Improve Skin Health:
Squalene is a major component of skin oil,
often known as sebum. It hydrates the skin
while also protecting it from ultraviolet (UV)
damage.
Radiation Illness may be Avoided: Radiation
treatment harms, such as tissue damage,
are considerably reduced when AKGs are
present in the oil.
It may help with Mouth ulcers: Because of
its immune-boosting properties, SLO has
the potential to drastically minimize the
occurrence of recurring mouth ulcers.

11. Precautions and Side Effects
SLO has no documented negative side
effects. But it is important to take
precautions for your health. Book the Most
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However, as previously stated, there is
considerable debate over SLO’s influence
on blood cholesterol levels, particularly
when ingested in large amounts.
As a result, anybody with a cardiac
condition should avoid using this product.
Squalene produced from the oil may also
cause SLO-induced pneumonia, according
to previous human and animal research.
Furthermore, one individual who
supplemented with two SLO capsules daily

12. for two weeks had a liver impairment,
resulting in hazardous levels in the liver.
As a result, before supplementing with SLO,
visit your healthcare physician.
Finally, although sharks are susceptible to
heavy metal pollution, particularly mercury
contamination, evidence shows that it
accumulates mostly in muscle tissue and
fins.
Previous research even claims that mercury-
exposed fish have low mercury levels in
their oils, implying that the metal eliminates
during the production process.
Dosage and Administration
There isn’t much information on how much
SLO to take or how long to supplement with

13. it. Intake requirements are state base
demands of users and prior ailments.
However, one research showed that taking
500 mg of SLO twice a day before surgery
might help with immunity and wound
healing.
However, bear in mind that larger dosages
of roughly 15 grams per day link negative
effects on blood cholesterol levels.
Although manufacturers suggest taking
your SLO supplement with meals to
increase absorption. There is no scientific
proof to support this claim.
As a result, it’s crucial to stick to your
healthcare provider’s dose, duration, and
ingestion directions.

14. Overdose
Despite its putative heart-health
advantages, several pieces of research
show that a daily SLO intake of 15 grams
or more may raise blood cholesterol levels
and reduce HDL (good) cholesterol levels.
These impacts on blood cholesterol levels
would be harmful to your health and might
contradict SLO’s anti-atherosclerotic effect,
or capacity to prevent plaque from forming
in your arteries.
Interactions
There have been no known interactions
between SLO and meals or medications.
This isn’t to say that they won’t happen.
SLO, for example, is rich in omega-3 fatty
acids, which belief to decrease blood
pressure. As a result, when used with blood

15. pressure medications, it may have an
additional impact.
Similarly, since omega-3 PUFAs thin the
blood, it’s thought that taking them along
with blood thinners like aspirin or warfarin
might raise the risk of bleeding. Despite
this, scientific data is inconclusive.
Before using SLO, talk to your doctor to be
sure you’re not putting yourself in danger.
Handling and storage
SLO is prone to oxidation because of its
omega-3 PUFA concentration, which means
it may quickly get rancid.
Omega-3 supplements that oxidize may
lose their effectiveness and cause health
problems.

16. Exposure to light, heat, and air are all
things that might cause your SLO
supplement to lose its freshness. As a result,
some people advise keeping it in a cool,
dark spot or even refrigerating it.
After opening, most omega-3 pills are safe
for roughly 3 months. Even when kept in
the dark at 39°F (4°C), they may develop
rancid after one month.
As a result, be sure to follow the storage
and handling instructions for your
supplement.
Breastfeeding and Pregnancy
Oral supplementation with SLO during
pregnancy enhanced white blood cell count
in offspring and mother’s colostrum. The
initial form of breast milk — indicates a

17. possible enhancement in offspring
immunity, according to animal studies.
However, there is no scientific proof that
SLO has any impact on pregnant or nursing
women, thus it should avoides.
Use in Certain Groups of People
SLO may be generally safe for most
individuals, except for possible negative
effects in those with heart disease and those
using blood-pressure-lowering and blood-
thinning medicines.
SLO may also be an alternate source of
omega-3 for persons who are allergic to
fish. This is owing to cartilaginous fish like
sharks having low allergenicity among
individuals who cannot tolerate bony fish.
Alternatives

18. While AKGs, squalene, and omega-3
PUFAs are abundant in SLO and are
responsible for most of its health benefits.
They may find other foods and
supplements.
AKGs, for example, may be present in
cow’s milk and ratfish liver oil.
Squalene may find in olive, palm, wheat
germ, amaranth, and rice bran oil in
acceptable proportions.
Finally, omega-3 PUFAs may find in fatty
fish, fish oil, chia seeds, flax seeds, and
flaxseed oil, among other animal and
plant-based sources.
Final Thoughts
Shark liver oil has several benefits for
health, but it is important to remember that

19. it is not a miracle cure. It is important to
consult with a healthcare professional
before taking any supplements and to heed
any warnings that come with the product.
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References
Ariane Lang. (2020, September 17). Shark
Liver Oil: Benefits, Uses, and Side Effects.

20. Retrieved from Healthline:
https://www.healthline.com/nutrition/shark-
liver-oil
What Is Shark Liver Oil Used For? (n.d.).
Retrieved from Vitagene:
https://vitagene.com/blog/shark-liver-oil/