2. DRUG PROFILE OF
PIROXICAM

3. PRESENTED TO:
Dr. Samreen Faisal
PRESENTED BY:
Ahad Nawaz
Pharm-D 4th Prof

4. •
Contents
Introduction
• Product Description
• Chemistry of Drug
• Pharmacokinetics
• Clinical Pharmacology
• Dosage Schedule
• Precautions
• Side Effects
• Administration Guidelines
• Drug-drug Interactions
• Drug Food Interactions
• Therapeutic Drug Monitoring
• Toxicology
• References

5. Introduction
• Generic Name: Piroxicam
• Drug Category: Prescribed
• National Essential Drug List: Present
• WHO Essential Drug List: Present

6. Product Description

7. Feldene
• Generic: Piroxicam
• Dosage form: Tab/Cap/Gel/Inj
• Available strength:
10- 20mg/0.5%w/w& 20mg/ml
• Manufactured By: Pfizer

8. Oricam
• Generic: Piroxicam
• Dosage form: Tab & Cap
• Available strength:10-20mg
• Manufactured By: Axis Pharma

9. Diodex
• Generic: Piroxicam
• Dosage form: Tab/Cap & Gel
• Available strength: 20mg/ 0.5% w/w
• Manufactured by: Pearl Pharma

10. CHEMISTRY OF DRUG
Chemical class:
Enolic acid derivative
Chemical Nature:
Acidic
Molecular formula/weight:
C15H13N3O4S / 331.35
Physical Properties:
 Off-white to yellow crystalline powder
 Melting Point is198° to 200°c

11. Pharmacokinetics

12. Absorption
Piroxicam is absorbed completely
after oral administration and
undergoes enterohepatic
circulation.
Peak concentrations in plasma
occur within 3-5hours

13. Distribution
• Bioavailability:
65-90%
• Protein Binding:
99%
• Blood Brain Barrier:
Not cross the BBB
• Secreted in Milk:
Yes
• Volume of Distribution:
0.14L/kg

14. Elimination
Half Metabolism Active Route of
Life Metabolite Excretion
50h Metabolise in the Yes Excreted
liver. The major through
metabolic
Urine and
transformation is
CYP-mediated Feces
hydroxylation to
an inactive
metabolite and
its glucuronide
conjugate.

15. Clinical
Pharmacology

16. Pharmacologic NSAIDs
al Class
Therapeutic Analgesic, Anti-inflammatory,
Class Antipyretic
MOA It inhibits cyclooxygenase and
blocked the synthesis of
prostaglandins.
Contra- Inflammatory bowel disease ,
indications Pregnancy, Hypersensitivity to
drug
FDA Pregnancy Pregnancy Category D
Class

17. Dosage Schedule

18. Rheumatoid Arthritis
• Route of Administration:
Oral / Parenteral
• Recommended Dose:
20mg Once daily
• Duration of Therapy:
7 to 12 Days

19. Osteoarthritis
• Route of Administration:
Oral / Parenteral
• Recommended Dose:
20mg Once daily
• Duration of Therapy:
7 to 12 Days

20. Ankylosing Spondylitis
• Route of Administration:
Oral / Parenteral
• Recommended Dose:
20mg Once daily
• Duration of Therapy:
7 to 12 Days

21. Juvenile Rheumatoid
Arthritis
• Route of Administration:
Oral / Parenteral
• Recommended Dose:
5-15mg Once daily according
to body weight of the child
• Duration of Therapy:
5 to 8 Days

23. Side Effects
GI disturbances including
Discomfort, Nausea, Diarrhoea,
Heartburn, bleeding& Ulceration.
Rash, Dizziness, Tinnitus
Hepatic damage
Alveolitis, Pulmonary eosinophilia, Apnea
Dyspepsia, Increase bleeding time

24. Storage
Keep medicine out of the reach of
children.
Store in a dry place,
Protect from sunlight and
moisture
Store below 30°C

25. Precautions
• Piroxicam should be used with caution
in patients with coagulation defects &
• Patients on anticoagulant therapy.
• Discontinue drug if skin reaction
occurs.

26. Administration
Guidelines
• Give with milk, antacids, or food to
minimize GI upset.

27. Drug-Drug Interactions
Interacting Mechanism Outcome
Drug
Methorexate Piroxicam have been Eenhance the
competitively inhibit toxicity of
methotrexate methotrexate
accumulation in kidney
slices.
Diuretics Also Inhibits the renal Reduce the
prostaglandin synthesis netriuretic effect of
(Thiazide & which is responsible for diuretics
Furosemide ) netriuretic effect.
Warfarin It also inhibit the Increase bleeding
platelets aggregation . time
ACE Its have the maximum Reduce the
protein binding then ace antihypertensive
inhibitors inhibitors effect ace
inhibitors

28. Drug-Food Interactions
Piroxicam have not shown any
food interaction.

29. Therapeutic Drug Monitoring
• NSAIDs have the wide therapeutic
index so due to this reason they don’t
require therapeutic drug monitoring

30. Toxicology
Toxic Dose Symptoms Treatment
60-80mg for 3 Lethargy, No specific
days Drowsiness, antidotes
Nausea,
vomiting, Emesis or
Epigastric pain. activated
Hypotension, charcoal or
Acute Renal osmotic
failure, cathartic may
Respiratory be used to
depression and overcome the
Coma may toxicity
occur

31. REFERENCES
 Basic & Clinical Pharmacology_
Bertram_G._Katzung- 9th Edition Page 823
 Goodman & Gillman's Manual of
Pharmacology &
therapeutics-2008 Page-453
 BNF 61st Edition Page-639
 Clarke's Analysis of Drugs and Poisons 3rd
Edition Page-521