http://technologyinscience.blogspot.com/2013/07/single-use-bioreactor-types-advantages.html A single-use bioreactor (S.U.B) or disposable bioreactor is a bioreactor with a disposable bag instead of a culture vessel.

1. Single Use Bioreactors
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2. Single Use Bioreactor
• A single-use bioreactor (S.U.B) or disposable bioreactor is a
bioreactor with a disposable bag instead of a culture vessel
made from stainless steel or glass.

3. Types of Single Use Bioreactors
Stirrer Type Rocking Motion Type

4. Advantages of Single Use Bioreactors
• Eliminates validation issues because the cleaning process is
avoided.
• Shortens downtime and turnaround time because no cleaning is
required.
• Lowers risk of cross-contamination with use of new bags for each
run.
• Offers multiple advantages based on the elimination of the cleaning
process.
• Decreased operating costs and capital investment: savings on start-
up capital costs as well as utilities, space, and labor requirements.
• Cost savings from reduced cleaning
• Validation is reduced because systems are less complex.
• Ease of installation.
• Ease of moving when empty.

5. Disadvantages of Single Use
Bioreactors
• Limitation in liquid transfer.
• Scalability is an issue.
• Expensive to use.
• Performance is not completely proven.
• Slight increase in variable costs per run.
• Leachables and inability to store hot liquids.
• Potential for puncture.
• Difficulty in moving when full.
• Pressure and temperature sensitivity.
• Disposal costs.

6. Progress for Single Use Bioreactor
• Wide acceptance of bioprocess bags
• Single use bioreactors are scalable and performance is
comparable to Stainless Steel bioreactors.
• 1000L Bioreactor scales can open up opportunitiesin
commercial applications.

7. List of Commercially available Single
Use Bioreactor Systems
• XDR - Xcellerex
• Mobius - Millipore
• CelliGen BLU - eppendorf
• Hyclone S.U.B - Thermo Scientific
• Single Use Bioreactor – Applikon

8. Thank You
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bioreactor-types-advantages.html