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Drug of choice (1)

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Drug of choice (1)

  1. 1. TREATMENT OF CHOICE 1) Erythrodermic Psoriasis - Methotrexate 2) Psoriatic arthropathy - Methotrexate 3) Severe Erythrodermic Psoriasis - Cyclosporine 4) Pustular Psoriasis - acitretin (Retinoid) 5) Impetigo herpetiformis - Systemic Steroids 6) Arthritis mutilans - Etanarcept 7) Guttate Psoriasis - Macrolide 8) Genital warts - Podophyllin( C.I in pregnancy), Imiquimod 9) Genital warts in pregnancy - Cryotherapy > Trichloroacetic acid 10) Syphilis - Benzathine Penicillin 2.4 million units 11) Neurosyphilis - Aqueous Penicillin 12) Herpes - Acyclovir or foscarnet 13) Donovanosis - Azithromycin or Doxycycline 14) LGV - Doxycycline or tetracycline 15) Chancroid - ceftriaxone > Azithromycin 16) Neisseria - Ceftriaxone 17) Cryptococcus - Induction:Amphotericin….Maintenance: Fluconazole 18) Pneumocystis carinii - Cotrimoxazole* 14d (21d in HIV) 19) Invasive aspergillosis - Voriconazole 20)Aspergillosis - itraconazole 21) Sporothrix - Itraconazole 22) Blastomycosis - amphotericin B 23) Coccidiodomycosi - Itraconazole 24)Paracoccidiodomycosis - Itraconazole 25) Dermatitis herpetiformis - Gluten free diet > Dapsone(DOC) 26)Pemphigus vulgaris - Prednisolone 27) Porphyrea cutanea Tarda - Venesection > Low dose Chloroquine 28)Xerostomia - Cevimiline (muscarinic agonist) 29)Atropine( Belladona Poison) - Physostigmine 30)Alzheimer’s disease - Donepezil( Tertiary carbamate) 31) Diagnosis of Myasthenia - Edrophonium 32) Myasthenia gravis - Pyridostigmine 33) Open angle Glaucoma - prostaglandins analogues
  2. 2. 34)Closed angle glaucoma - acetazolamide 35) COPD - Anti cholinergics ( Tiotropium) 36)Overflow incontinence - neostigmine or bethanechol 37) Urge incontinence - Darifenacin>solefenacin>trospium>tolterodin 38)Motion sickness - Hyoscine( Scopalamine) 39)OP Poisoning - Atropine 40)Vitiligo - corticosteroids 41) Androgenic Alopecia - Minoxidil > Finasteride 42)Tinea capitis - Griseofulvin 43)Rosacea - Metronidazole cream twice daily 44)C.jejuni - Quinolones 45)Guillian Barre Syndrome - I.V.Immunoglobulins or plasmapheresis 46) Transverse myelitis - I.V. methylPrednisolone 47)Chronic inflammatory - I.V. methylPrednisolone demyelinating polyneuropathy 48)Blindness in Multiple sclerosis - I.V. methylPrednisolone 49) Trigeminal neuralgia - Carbamazapine + gabapentin 50) Multiple sclerosis - Interferon B i.m every week for 6-8months 51) Devic disease - I.V.methylPrednisolone 52) Neurocysticercosis - Albendazole 53) Drug induced parkinsonism - anticholinergics(benztropine/trihexyphenidyl) 54)Cyanide poisoning - Na. thiosulphate+ I.V Vit.B12 55) CO Poisoning - Hyperbaric O2 56)Huntington chorea - Tetrabenzene 57)Shy dragger Sx/ - Levodopa multi system atrophy 58)Supranuclear palsy - levodopa 59)Cheese reaction( Selegelline tox.) - I.V.Phentolamine 60)Wilson disease - Zinc acetate 61) Wilson disease (CNS involved) - Tetrathiomolybdate 62) Neonatal memingitis - Cefotaxime 63)Meningitis - Ceftriaxone 64)T.B Meningitis - A.T.T + Steroids 65)Absence seizures - Valproate 66)Juvenile myoclonic epilepsy - Valproate 67)Rolandic or focal seizures - carbamazapine 68) Lennox- Gestaut Sx - Valproate+ Clobazam/rufinamide 69) Febrile Seizures - Diazepam or intranasal Midazolam
  3. 3. 70)Infantile spasm - ACTH 71) Infantile spasm(tuberous sclerosis) – Vigabatrin 72) Epilepsy in pregnancy - Lamotrignine 73) Absence seizures <3ys age - Ethosuximide 74)Status epilepticus - lorazepam Phenytoin Valproate Midazolam+intubate 75) GTCS/Atonic seizure - Valproate 76)Tuberous sclerosis - Vigabatrin/Lamotrignine 77) Refractory epilepsy - Stereotactic surgery 78)Myasthenia crisis - I.V Ig+ I.P.P.V 79)Ocular Myasthenia gravis - steroids > pyridostigmine 80)Lambert –eoton Sx - 3,4-aminopyridine+Pyridostigmine 81) Oat cell Ca. - Cisplatin/Carboplatin + irinotecam/etoposide 82)CMV - Ganciclovir 83)Toxoplasmosis - Pyrimethamine + sulfadoxine 84)Hydrocephalus - Glycerol or acetazolamide 85)Alzheimer’s Disease - Donepezil>Memantile,galantamine,rivastigmine 86)Mild to moderate Migraine - NSAIDs 87)Severe Migraine - Sumatriptan 88)Prophylaxis of Migraine - Propranolol>flunarazine,gabapentin,amitryptiline 89)Status Migrainicus - Prochlorperazine 90)1* cluster headache - Verapamil+gabapentin+amitryptiline 91) TOC for cluster headache - High flow O2 92)DOC for cluster headache - I.V.Sumatriptan 93)Dengue Hemorrhagic Fever - platelets 94)Dengue shock syndrome - colloids 95)Dengue fever - PCM (COX1 inhibitors are C.I) 96)Temporal Arteritis - Steroids 97)Actinomycosis - Penicillin> clindamycin or erythromycin 98)Nocardia - Sulfonamides 99)H.pylori - OCM/OCA 7-14d—if fails OBMT
  4. 4. 100) Campylobacter - Erythromycin 101) Mycoplasma pneumonia - Azithromycin 102) Ureaplasma urealyticum - Azithromycin 103) M.hominis - Doxycycline 104) Pseudomonas - C- Carbapenams,ciprofloxacin,cephalosporins A- Aminoglycosides P- Piperacillin,mazlocillin,nafcicillin 105) Plague - Streptomycin or Gentamycin 106) Plague prophylaxis - Doxycycline 107) Shigella - Ciprofloxacin 108) MDR Typhoid - Ciprofloxacin 109) Nalidixic acid resistant typhoid - Ceftriaxone 110) Listeria - Ampicillin+ gentamycin(if memingitis+) 111) Lyme disease - Doxycycline 112) Leptospirosis - Mild:Doxycycline…..Severe: Penicillin 113) H.Influenae - Cephalosporins> Quinolones..prophylaxis:Rifampicin 114) Bordetella - erythromycin 115) Brucella - Streptomucin+doxyxycline 116) Chlamydia - Azithromycin>Tetracycline 117) Rickettsiae - Doxycycline 118) Typical cat scratch disease - Azithromycin 119) Atypical cat scratch disease - Doxycycline 120) Bacillary angiomatosis - Erythromycin 121) Trench fever - Gentamycin+Doxycycline 122) Oroya fever - Chloramphenicol or Ciprofloxacin 123) Bacteroides fragilis - Metronidazole+surgical debridement 124) Dermatophyte - Griseofulvin 125) Treatment resistant schizophrenia - Clozapine 126) Suicidal tendencies - Clozapine 127) Neurolept malignant Sx - Dantrolene 128) Acute dystonia - Benzhexol or trihexy phenidyl 129) Akathisia - Propranolol 130) Schizophrenia in pregnancy - ECT 131) Catatonia - I.V.Lorazepam 132) Jat leg Sx - Ramalteon 133) Periodic limb movement disorder - Clonazepam 134) Restless leg Sx(Ekbom Sx) - pramipixole/ropinerole: dopamine agonists 135) Narcolepsy - Modafinil
  5. 5. 136) Nocturnal enuresis - behavioural therapy>desmopressin>Imipramine 137) Night terrors - Benzodiazepines 138) Seasonal depression - Light/Phototherapy 139) Atypical depression - MAO inhibitors 140) Mania in pregnancy - Olanzapine>haloperidol 141) Mania - Lithium 142) Rapid cyling bipolar disorders - valproate >carbamaapine 143) Mania with comorbidities - valproate > carbamaapine 144) Dysthymia - SSRIs 145) Cyclothemia - Mood stabilizers(Lithium,Valproate,Carbamazapine,lamotrignine) 146) Grief psychosis - Anti Psychotics 147) Lithium induced DI - Amiloride 148) Serotonin Sx - Cyproheptadine 149) Cheese reaction - Phentolamine 150) Hypoactive sexual disorder - Flibanserin 151) Erectile dysfunction - Phosphodiesterase 5 inhibitor:Sildenafil 152) Reynaud’s phenomenon - CCBs 153) Anxiety disorder - Cognitive behavior therapy(CBT) 154) Best Rx for Anxiety disorder - SSRIs+benzodiazepines+CBT 155) Phobias - CBT(Psychotherapy) > SSRIs+benzodiazepines 156) OCD - Fluvoxamine 157) ADHD - Methylphenidate 158) B-Bacillus L- Leptospira A- actinomyces S- Streptococcus PENICILLIN-G T- Treponema My- Meningococcus Penicillin:Petuenae,pastuerella G- Gas Gangrene 159) staphylococcus - Penicillin 160) MRSA - Vancomycin>FQs,chloramphenicol, Cotrimoxazole,Doxycycline 161) VRSA - Daptomycin 162) Surgical prophylaxis - Cefazolin 163) H.influena meningitis - Ceftriaxone 164) H.influenzae pneumonia or otitis - Ampicillin+Sulbactam
  6. 6. 165) My- Mycoplasma hominis Pink- Plague prophylaxis R- Rickettsia DOXYCYCLINE B- Borellia,Brucella C-Chlamydia,Cholera 166) E.faecalis - ampicillin>Vancomycin 167) E.faecium - Vancomycin 168) Bacterial vaginosis in Pregnancy - Clindamycin 169) Diphtheria - Erythromycin 170) Pertussis - Erythromycin 171) C.jejuni - Erythromycin 172) M.pneumoniae -Azithromycin 173) Legionella -Azithromycin 174) Chancroid -Azithromycin 175) Cholera & Chlamydia in pregnancy -Azithromycin 176) MAC - Clarithromycin 177) C.difficile - Metronidaole>Vancomycin 178) Pneumocystis - Cotrimoxazole 179) Nocardiosis - Cotrimoxazole 180) Cystitis - Cotrimoxazole 181) Toxoplasmosis - Sulfadoxine+Pyrimethamine 182) Toxoplasmosis in pregnancy - Spiramycin 183) Acute cholecystitis - Cholecystectomy 184) Acute gout - Indomethacin > colchicine 185) Chronic gout - Allopurinol 186) Pseudogout - steroids 187) Pleuritis in SLE - Steroids 188) Libmann sacks Endocarditis - Valvuloplasty 189) Pericarditis in SLE - Steroids 190) Aphthous Ulcer - Topical benzocaine 191) Aphthous ulcer in SLE - Steroids 192) Aphthous Ulcer in Behcet disease - Steroids 193) RA - DMARDs M-Methotrexate A- Azathioprine S- Sulfasalaine H-Hydroxychloroquine L- Leflunamide
  7. 7. 194) Acute RA - Steroids 195) Photosensitivity - Hydroxychloroquine 196) Porphyrea cutanea Tarda - I.V.Haem > Hydroxychloroquine 197) Analgesic of choice in pt. of - Acetanimophen RA with Hemophilia 198) Mixed Connective tissue disorder - D-Penicillamine 199) Ankylosing spondylitis - Indomethacin 200) Raynaud’s phenomenon - Amlodipine(Ca channel blockers) 201) Hemochromatosis - Phlebotomy 202) Polycythaemia vera - Phlebotomy 203) Scleroderma - D-Penicillamine 204) Scleroderma crisis - ACEIs > aliskrin 205) Intermittent claudication - Cilastazole 206) Hypertensive crisis - Clevidipine Labetalol Furosemide Fenoldopam Uradapil 207) Hypertensive urgency - ACEIs 208) Eclampsia - MgSO4 209) HTN Crisis in pregnancy - Labetalol 210) Reiter’s disease -Indomethacin 211) Behcet’s disease - Steroids 212) U/L Renal A. Stenosis - ACEIs or ARBs 213) B/L Renal A. Stenosis - Renal Angioplasty 214) Wegener’s Granulomatosis - Cyclophosphamide 215) Temporal arteritis - Steroids 216) Kawasaki Disease - I.V. Immunoglobulins 217) Scarlet fever - Ampicillin 218) HSP = Steroids 219) Myasthenia gravis = I.V. Immunoglobulins 220) GBSx = I.V. Immunoglobulins 221) ITP = I.V. Immunoglobulins 222) Hepatitis B = Entecavir 223) Hepatic encephalopathy =Lactulose 224) Acute bleeding Gastric Ulcer - Proton pump inhibitors 225) Acute colonic pseudo-obstruction - Neostigmine (Ogilvie’s Sx) 226) Aspiration pneumonia or - H2 Blockers Prophylaxis of surgical patients
  8. 8. 227) Chemotherapy induced vomiting Early onset - Ondansetron Late onset - Aprepitant 228) Dyspepsia Gastrinoma Zollinger Ellison Sx NSAIDs induced Ulcer Proton pump inhibitors Peptic ulcer disease Stress Ulcer GERD 229) GERD in pregnancy - Antacids 230) Hemochromatosis - phlebotomy> Desferoxamine 231) Hiccoughs - Chlorpromazine 232) HIV ass. Secretory diarrhea - Octreotide 233) Maintenance & induction in UC - Mesalamine > Steroids 234) Steroid dependant in induction of UC- Azathioprine 235) Steroid resistant in induction of UC - Cyclosporine 236) Maintenance & induction in CD - Anti TNF-@ ;Infliximab/etanarcept 237) Induction of mild case of CD - Steroids 238) Irritable Bowel Sx; Diarrhoea - Loperamide Constipation - ethylene Glycol> Lubipristone 239) Morning sickness - Pyridoxine + doxylamine 240) Sclerosing cholangitis - Steroids 241) Whipple’s disease - Cotrimoxazole 242) Wilson disease - Zinc 243) Wilson disease with liver# - Zinc + Trientene 244) Wilson disease with neuropsyc. - Tetrathiomolybdate 245) Xerostomia - cevimiline > pilocarpine 246) Most specific drug for NSAID - Misoprostol(PGE1 analogue) Induced ulcer 247) Drugs causing peptic ulcer - Anti Cancer agents Steroids NSAIDs Clopidogrel Bisphosphonates Mycophenolate mofetil 248) Acute attack of Angina - Sublingual NTG 249) Prevents mortality in Angina - Beta blockers 250) Prinzmetal’s angina - Sublingual NTG
  9. 9. 251) Aortic dissection - Labetalol 252) AF & Flutter: Acute - I.V.Ibutilide Rhythm control - Amiodarone Rate control - Beta blockers Anticoagulant - Dabigatran or Apixaban 253) Acute CHF - Furosemide 254) Inotrope of choice in Acute CHF - Dobutamine 255) Chronic CHF - ACEIs or ARBs 256) Hypertriglyceridemia - Fibrates 257) Type 3 Hyperlipoproteinemia - Fibrates 258) Hypercholesterolemia - Statins 259) Hypercholesterolemia in pregnancy - bile acid sequestrants 260) Hypertension in Young - ACEIs or ARBs 261) Hypertension in Elderly - CCBs 262) Resistant hypertension - Aldosterone antagonists 263) HTN with DM CKD ACEIs or ARBs Scleroderma Nephritic Sx 264) HTN with Previous MI Angina Hyperthyroidism Migraine BETA BLOCKERS Tremors Anxiety AF Preop HTN 265) HTN with Osteoporosis - Thiazide Diuretics 266) HTN with Reynaud’s Disease - CCBs 267) HTN with Cyclosporine induced - CCBs Hypertension 268) HTN with Dyslipidemia Alpha-1-Blocker BPH 269) Hypertensive Emergency - I.V.Nicardipine 270) Hypertensive Urgency - Clonidine 271) Hypertensive Emergency with Scleroderma - Captopril 272) PSVT - Adenosine 273) PSVT Prophylaxis - Verapamil or Beta Blockers 274) Anaphylactic Shock - Epinephrine
  10. 10. 275) Cardiogenic Shock - Norepinephrine or Dopamine 276) Septic Shock - Norepinephrine 277) Vasodilatory Shock - Norepinephrine 278) SVT Treatment & Prophylaxis - Verapamil> Beta blockers 279) SVT ass. With CHF - Digoxin 280) Torsades de pointes - MgSO4 281) Ventricular extrasystole - Beta Blockers 282) Ventricular fibrillation - Amiodarone 283) Ventricular Tachycardia - Lidocaine 284) WPW Sx - Procainamide 285) Cystinuria - Tiopronin( Cystin binding agent) + Urine alkaliser 286) Pulmonary edema with CHF - Furosemide 287) Edema by liver cirrhosis - Spironolactone 288) Resistant edema - Spironolactone 289) Cerebral edema - Mannitol 290) Lupus nephritis - Cyclophosphamide+ Glucocorticoids 291) RPGN - Cyclophosphamide+ Glucocorticoids 292) Nephrotic Sx - Steroids 293) Steroid resistant Nephrotic Sx - Cyclosporine 294) Steroid dependant Nephrotic Sx - Cyclophosphamide 295) Relapsing Nephrotic Sx - Cyclophosphamide 296) Overflow incontinence - Cholinergics(Bethanechol) 297) Urge incontinence - Anticholinergics(Darifenacin) 298) Stress incontinence - Duloxetine(SNRI) 299) Cystitis - Cotrimoxazole 300) Pyelonephritis - Ciprofloxacin 301) Spont.Bact.Peritonitis - Cefotaxime 302) Drugs causing Pancreatitis - Azathioprine 5-Mercaptopurine Sulphonamides Anti HIV drugs Valproate Estrogen Tetracycline 303) Primary biliary Cirrhosis - Liver Transplantation 304) Hepatic encephalopathy - Lactulose 305) Antibiotic of choice in HE - Rifaxamin 306) Kidney stones - PCNL+ ESWL
  11. 11. 307) All nematodes except onchocerca Filariasis ALBENDAZOLE Loa loa Strongyloides 308) Onchocerca - Ivermectin 309) Srongyloides(Thread worm) - Ivermectin 310) Loa loa - Diethyl carbamazine 311) Filariasis - Diethyl carbamazine 312) Neurocysticercosis 313) Echinococcus albendazole 314) T.solium 315) T.saginata Praziquentel> Niclosamide 316) H.nana 317) Diphylobothrium 318) Liver fluke - Triclabendazole 319) Lung flukes - Praziquentel 320) Schistosomiasis - Praziquentel 321) Drugs causing Hypocalcemia - Alcohol Anticonvulsants Corticosteroids Lithium Heparin Thyroxine Cyclosporine 322) Malaria in pregnancy - Chloroquine 323) Severe/complicated malaria in preg. – Quinine 324) Extra amniotic instillation for MTP - Ethacrydine Lactate 325) Ovulatory DUB - NSAIDs + Transexanamic acid 326) Anovulatory DUB - Progesterone 327) Contraception for newly married - OCPs 328) Couple who meet occasionally - Barrier Methods 329) Lactating females - progestogen only pill 330) Post pill amenorrhoea - Clomiphene Citrate 331) Hot flashes - Estrogen 332) Decreased post menopausal libido - Testosterone/Androgens 333) Senile vaginitis - topical estrogen 334) Contraception for sickle cell anemia - DMPA Depot i.m 335) Premenstrual Sx - SSRIs 336) Bacterial vaginosis in Pregnancy - Metronidaole 337) Pneumocystis in Pregnancy - Sulphamethaxozole+ Trimethoprim
  12. 12. 338) Typhoid in Pregnancy - 3rd gen. Cephalosporins 339) Syphilis in Pregnancy - Penicillin 340) Gonorrhoe in Pregnancy - ceftriaxone 341) Chlamydia in Pregnancy - Azithromycin> Erythromycin 342) Grp B Streptococcus - Penicillin> Ampicillin 343) Appendicitis in Pregnancy - Appendicectomy 344) Red degeneration - Conservative 345) Thyrotoxicosis in Pregnancy - Propylthiouracil 346) Prolactinomas - Dopamine agonists {Cabergoline/Bromocriptine} 347) contraception rheumatic heart disease - Condom 348) Acute promyelocytic Leukemia - All Trans Retinoic Acid/ Arsenic Trioxide 349) ALL - Vincristine Adriamycin L-Asparaginase Prednisolone + Intra thecal Methotrexate 350) AML - Same as ALL except Methotrexate 351) CML - Imatinib(Tyrosine kinase inhibitor) 352) CLL - Fludarabine 353) Hodgkin’s disease - ABVD 354) Non Hodgkin’s disease - R-CHOP 355) Juvenile myelomonocytic leukemia - Cis retinoic acid 356) Acute iron poisoning - Parenteral Desferroxamine 357) Chronic iron poisoning - oral deferiprone 358) Post coital contraception - Levonorgestrel 359) Digitalis toxicity - lignocaine 360) Delirium tremens - Benzodiazepines 361) Delirium - Antipsychotics + benzodiazepines 362) PDA - Indomethacin 363) To maintain PDA - Misoprostol> PGE2 Analogue( Alprostadil) 364) Acute mountain sickness - Acetazolamide 365) Acetaminophen toxicity - N-Acetyl Cysteine 366) Allergic rhinitis - Steroids 367) Ankylosing spondylitis - NSAIDs 368) Cold agglutinin disease - Rituximab 369) Familial Meditarean fever - Colchicine 370) Genital Warts - Males: Podophyllin….Female: Imiquimod 371) Acute Gout - Indomethacin 372) Chronic gout - Allopurinol
  13. 13. 373) Head lice - Permethrin 1% cream 374) Hypersensitivity reaction - Epinephrine 375) Pseudotumor Cerebri - Acetazolamide 376) Migraine Prophylaxis - Propranolol 377) Migraine treatment - Sumatriptan 378) Morning sickness - Doxylamine 379) Tumor lysis Sx - Allopurinol 380) Urticaria - 2nd generation AntiHistaminics 381) DOC for RA - Methotrexate 382) Heparin induced thrombocytopenia - Direct thrombin inhibitors(best:Argatroban) 383) Hairy cell leukemia - cladribine 384) Pancreatic carcinoma - Gemcitabine 385) GIST - Imatinib 386) SIADH - Demeclocycline(Tetracycline) 387) Only drug for Sickle Cell Anemia - Hydroxyurea 388) Steroid dependant Nephrotic Sx - Cyclophosphomide 389) Steroid Resistant Nephrotic Sx - Cyclosporine 390) Prenatal Cong. adrenal hyperplasia - Dexamethasone 391) Diag. case of CAH - Hydrocortisone 392) Drugs causing SLE - S – Sulfonamides H- Hydralazine I – Isoniazid P – Procainamaide 393) Drugs causing gynecomastia - D- Digitalis I – Isoniazid S – Spironolactone C – Cimetidine O – Oestrogen 394) Intranasal drugs - Desmopressin GnRH agonist Calcitonin Fentanyl 395) Acidic drugs - Weak – Warfarin A – Antiepileptics(Phenytoin & Phenobarb) Antifolate: Methotrexate/Sulfametha. C – Chlorthiazide I – Ibuprofen & Aspirin D – levoDopa
  14. 14. 396) High first pass metabolism - Very – Verapamil High- Hydrocortisone M – Morphine E – estrogen T- Trinitrate glycerine A – AntiPsychotics B - Beta Blockers O – Opioids L – Levodopa / Lignocaine I – Isoprenaline S – Salbutamol/Saquinavir M – Midazolam 397) Enzyme Inducer - G – Griseofulvin P – Phenytoin R – Rifampicin S – Smoking Cell- Carbamazapine Phone- Phenobarbitone 398) Enzyme inhibitors - Vit. – Valproate K – Ketoconazole Can – Cimetidine Cause – Ciprofloxacin Enzyme - erythromycin Inhibition – Isoniazid 399) Zero order Kinetics - Zero W – Warfarin A – alcohol/aspirin T – Theophylline T – tolbutamide Power- Phenytoin 400) Drugs causing Hirsuitism - Heavy- Heavy metals People -Penicillin Are - Actazolamide Conducting C - Cyclosporins A - Androgens M - minoxidil P - Phenytoin For OCP - OCP Distribution- Danazol/Diazoxide

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