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Hodgkin lymphoma

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Hodgkin lymphoma

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Descripción

hodgkin lymphoma, nodular sclerosis, mixed cellularity, lymphocyte predominant, lymphocyte depletion, lymphocyte rich, ABVD regimen, reed sternberg cells, lacunar cell, popcorn cell

Transcripción

  1. 1. - Dr. Akif A.B - Step to PG-MD/MS/DNB - Dr.Akif A.B
  2. 2. -Arises in Lymph nodes -MC LN to involved is - Cervical - Step to PG-MD/MS/DNB - Dr.Akif A.B
  3. 3. -Pel Ebstein fever -Asymptomatic lymphadenopathy -Constitutional symptoms (unexplained weight loss [>10% of total body weight] within the past 6 months, unexplained fever >38º C, or drenching night sweats) collectively, these are known as "B symptoms B symptoms 1) unexplained fever >38º C 2) unexplained weight loss 3) drenching night sweats - Step to PG-MD/MS/DNB - Dr.Akif A.B
  4. 4. (high fever for 1-2 wk, followed by an afebrile period of 1-2 wk) - Observed only in 35% of patients - Step to PG-MD/MS/DNB - Dr.Akif A.B
  5. 5. STAGE 1 Only a single lymph node site or extranodal site is involved STAGE 2 Two or more lymph node sites on one side of the diaphragm are involved, -, or limited contiguous extranodal site involvement STAGE 3 Lymph node sites on both sides of the diaphragm are involved, with splenic or limited contiguous extradodal site involvement STAGE 4 Extensive involvement of extranodal sites, with or without lymph node involvement - Step to PG-MD/MS/DNB - Dr.Akif A.B
  6. 6. Classical Variety CD15+, CD30+ Non classical variety CD15- , CD30- , CD20+ Nodular sclerosis Lymphocyte predominant Mixed cellularity Lymphocyte rich Lymphocyte depletion - Step to PG-MD/MS/DNB - Dr.Akif A.B
  7. 7. Nodular Sclerosis Lacunar cells, Bands of fibrosis CD15+ , CD30+ Usually EBV- M=F Good Prognosis MC in world Mixed cellularity Mononucle ar cells CD15+ , CD30+ 70% EBV+ M>F Good prognosis MC in India Lymphocy te rich Reed- Sternberg cell CD15+ , CD30+ 40% EBV+ M>F Good prognosis Lymphocy te Reed sternberg CD15+ , CD30+ 90% EBV+ M>F Poorest prognosis - Step to PG-MD/MS/DNB - Dr.Akif A.B
  8. 8. Bands of fibrosis - Step to PG-MD/MS/DNB - Dr.Akif A.B
  9. 9. Bands of fibrosis - Step to PG-MD/MS/DNB - Dr.Akif A.B
  10. 10. In this lymph node, there are numerous scattered large cells with a surrounding prominent clear space surrounding the nucleus, an artefact of formalin fixation. These are the lacunar cells characteristic for the nodular sclerosis type of Hodgkin lymphoma. - Step to PG-MD/MS/DNB - Dr.Akif A.B
  11. 11. - Step to PG-MD/MS/DNB - Dr.Akif A.B
  12. 12. Mixed cellularity Hodgkin lymphoma showing both mononucleate and binucleate Reed-Sternberg cells in a background of inflammatory cells - Step to PG-MD/MS/DNB - Dr.Akif A.B
  13. 13. Nodular Lymphoctye Predominant Hodgkin lymphoma (NLPHL), with a popcorn-shaped Reed-Sternberg cel - Step to PG-MD/MS/DNB - Dr.Akif A.B
  14. 14. Albumin <4 g/dL Hemoglobin <10.5 g/dL Male Age ≥45 y Stage IV disease Leukocytosis: white blood cell count (WBC) >15,000/Μl Lymphopenia: Lymphocyte count <8% of WBC and/or absolute lymphocyte count <600 cells/μL Good risk : 0-1 Fair risk : 2-3 Poor risk : 4-7 - Step to PG-MD/MS/DNB - Dr.Akif A.B
  15. 15. A -Adriamycin B -Bleomycin V - Vinblastine D - Dacarbazine - Step to PG-MD/MS/DNB - Dr.Akif A.B

Descripción

hodgkin lymphoma, nodular sclerosis, mixed cellularity, lymphocyte predominant, lymphocyte depletion, lymphocyte rich, ABVD regimen, reed sternberg cells, lacunar cell, popcorn cell

Transcripción

  1. 1. - Dr. Akif A.B - Step to PG-MD/MS/DNB - Dr.Akif A.B
  2. 2. -Arises in Lymph nodes -MC LN to involved is - Cervical - Step to PG-MD/MS/DNB - Dr.Akif A.B
  3. 3. -Pel Ebstein fever -Asymptomatic lymphadenopathy -Constitutional symptoms (unexplained weight loss [>10% of total body weight] within the past 6 months, unexplained fever >38º C, or drenching night sweats) collectively, these are known as "B symptoms B symptoms 1) unexplained fever >38º C 2) unexplained weight loss 3) drenching night sweats - Step to PG-MD/MS/DNB - Dr.Akif A.B
  4. 4. (high fever for 1-2 wk, followed by an afebrile period of 1-2 wk) - Observed only in 35% of patients - Step to PG-MD/MS/DNB - Dr.Akif A.B
  5. 5. STAGE 1 Only a single lymph node site or extranodal site is involved STAGE 2 Two or more lymph node sites on one side of the diaphragm are involved, -, or limited contiguous extranodal site involvement STAGE 3 Lymph node sites on both sides of the diaphragm are involved, with splenic or limited contiguous extradodal site involvement STAGE 4 Extensive involvement of extranodal sites, with or without lymph node involvement - Step to PG-MD/MS/DNB - Dr.Akif A.B
  6. 6. Classical Variety CD15+, CD30+ Non classical variety CD15- , CD30- , CD20+ Nodular sclerosis Lymphocyte predominant Mixed cellularity Lymphocyte rich Lymphocyte depletion - Step to PG-MD/MS/DNB - Dr.Akif A.B
  7. 7. Nodular Sclerosis Lacunar cells, Bands of fibrosis CD15+ , CD30+ Usually EBV- M=F Good Prognosis MC in world Mixed cellularity Mononucle ar cells CD15+ , CD30+ 70% EBV+ M>F Good prognosis MC in India Lymphocy te rich Reed- Sternberg cell CD15+ , CD30+ 40% EBV+ M>F Good prognosis Lymphocy te Reed sternberg CD15+ , CD30+ 90% EBV+ M>F Poorest prognosis - Step to PG-MD/MS/DNB - Dr.Akif A.B
  8. 8. Bands of fibrosis - Step to PG-MD/MS/DNB - Dr.Akif A.B
  9. 9. Bands of fibrosis - Step to PG-MD/MS/DNB - Dr.Akif A.B
  10. 10. In this lymph node, there are numerous scattered large cells with a surrounding prominent clear space surrounding the nucleus, an artefact of formalin fixation. These are the lacunar cells characteristic for the nodular sclerosis type of Hodgkin lymphoma. - Step to PG-MD/MS/DNB - Dr.Akif A.B
  11. 11. - Step to PG-MD/MS/DNB - Dr.Akif A.B
  12. 12. Mixed cellularity Hodgkin lymphoma showing both mononucleate and binucleate Reed-Sternberg cells in a background of inflammatory cells - Step to PG-MD/MS/DNB - Dr.Akif A.B
  13. 13. Nodular Lymphoctye Predominant Hodgkin lymphoma (NLPHL), with a popcorn-shaped Reed-Sternberg cel - Step to PG-MD/MS/DNB - Dr.Akif A.B
  14. 14. Albumin <4 g/dL Hemoglobin <10.5 g/dL Male Age ≥45 y Stage IV disease Leukocytosis: white blood cell count (WBC) >15,000/Μl Lymphopenia: Lymphocyte count <8% of WBC and/or absolute lymphocyte count <600 cells/μL Good risk : 0-1 Fair risk : 2-3 Poor risk : 4-7 - Step to PG-MD/MS/DNB - Dr.Akif A.B
  15. 15. A -Adriamycin B -Bleomycin V - Vinblastine D - Dacarbazine - Step to PG-MD/MS/DNB - Dr.Akif A.B

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