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Smartphone cameras have the ability to be converted into ionising radiation detectors by covering the lens. The lens detects high-energy photons emitted by a variety of gamma radiation sources. The gamma detector is limited by its inability to differentiate between the energies of the radiation fields it is detecting, however the detector can be calibrated to give the estimated dose (μSv/hr). It has the ability to be used as a personal dosimeter. The detector is not very sensitive and is subject to thermal noise. The radiation intensity detected varies from phone to phone. However linearity plots of counts versus dose rate can be obtained regardless of noise or sensitivity values. The measurements of the detector are sensitive to the position and angle of the source. The following parameters were tested as part of this investigation: Calibration of device with sources, thermal noise, distance of source, shielding effects, resolving time of detector, variance of count rate with angle and absolute efficiency comparison to semiconductor detectors. The detector follows the radiation theory tested such as the inverse square law and the law of absorption. The Smartphone detector is a low cost dose meter that can provide estimated dose readings of radiation sources, although it is not as efficient as other semiconductor detectors, this low cost detector is much cheaper than its professional detector counterparts and there are more smartphones available than detectors. So the smartphone at times may be the best gamma detector available.
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An approach to discovering new immunotherapy targets for oncology is introduced and examples presented. New programs from biotech and pharma are discussed.
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upvita pandey
Smartphone cameras have the ability to be converted into ionising radiation detectors by covering the lens. The lens detects high-energy photons emitted by a variety of gamma radiation sources. The gamma detector is limited by its inability to differentiate between the energies of the radiation fields it is detecting, however the detector can be calibrated to give the estimated dose (μSv/hr). It has the ability to be used as a personal dosimeter. The detector is not very sensitive and is subject to thermal noise. The radiation intensity detected varies from phone to phone. However linearity plots of counts versus dose rate can be obtained regardless of noise or sensitivity values. The measurements of the detector are sensitive to the position and angle of the source. The following parameters were tested as part of this investigation: Calibration of device with sources, thermal noise, distance of source, shielding effects, resolving time of detector, variance of count rate with angle and absolute efficiency comparison to semiconductor detectors. The detector follows the radiation theory tested such as the inverse square law and the law of absorption. The Smartphone detector is a low cost dose meter that can provide estimated dose readings of radiation sources, although it is not as efficient as other semiconductor detectors, this low cost detector is much cheaper than its professional detector counterparts and there are more smartphones available than detectors. So the smartphone at times may be the best gamma detector available.
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PEPTIDE LABELLING & GAMMA RAY SPECTROSCOPY
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DoriaFang
Peptide vaccine containing only epitopes capable of inducing positive, desirable T cell and B cell mediated immune response. Peptides‖ used in these vaccines are 20–30 amino acid sequences that are synthesized to form an immunogenic peptide molecule representing the specific epitope of an antigen. sufficient for activation of the appropriate cellular and humoral responses Eliminating allergenic and/or reactogenic responses.
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Introduction: A high frequency of mutations affecting the gene encoding Herpes Virus Entry Mediator (HVEM, TNFRSF14) is a common clinical finding in a wide variety of human tumors, including those of hematological origin. Methods: We have addressed how HVEM expression on A20 leukemia cells influences tumor survival and its involvement in the modulation of the anti-tumor immune responses in a parental into F1 mouse tumor model of hybrid resistance by knocking-out HVEM expression. HVEM WT or HVEM KO leukemia cells were then injected intravenously into semiallogeneic F1 recipients and the extent of tumor dissemination was evaluated. Results: The loss of HVEM expression on A20 leukemia cells led to a significant increase of lymphoid and myeloid tumor cell infiltration curbing tumor progression. NK cells and to a lesser extent NKT cells and monocytes were the predominant innate populations contributing to the global increase of immune infiltrates in HVEM KO tumors compared to that present in HVEM KO tumors. In the overall increase of the adaptive T cell immune infiltrates, the stem cell-like PD-1- T cells progenitors and the effector T cell populations derived from them were more prominently present than terminally differentiated PD-1+ T cells. Conclusions: These results suggest that the PD-1- T cell subpopulation is likely to be a more relevant contributor to tumor rejection than the PD-1+ T cell subpopulation. These findings highlight the role of co-inhibitory signals delivered by HVEM upon engagement of BTLA on T cells and NK cells, placing HVEM/BTLA interaction in the spotlight as a novel immune checkpoint for the reinforcement of the anti-tumor responses in malignancies of hematopoietic origin.
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