G6PD deficiency is a genetic disorder classified into 5 classes based on enzyme activity level, ranging from severe deficiency with less than 10% activity to increased enzyme activity. Management involves avoiding oxidative stressors that can trigger hemolysis like fava beans, certain drugs, and chemicals. For acute hemolysis episodes, treatment may include blood transfusions. The main approach is preventing oxidative stressors that can cause red blood cell breakdown in those with the condition.