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Diabetes & Heart
Conventional Cardiac risk factors… superimposed on the diabetic state … Hypertension Microalbuminuria Inactivity South Asian origin Dyslipidaemia Obesity … further accentuate atherosclerosis in the diabetic state…accounting for the excess Cardiac risk
Why does diabetes  predispose to atherosclerosis? ,[object Object],High blood sugar High lipid Insulin resistance Alter the normal function of 3 different cell lines ARTERY … and their destruction leads to atherosclerosis Endothelial cell Platelet Smooth muscle cell
 
Heart Attack Which patient is at greater risk of future attack? An attack survivor A typical Type 2 diabetic
Risk Factors and C.H.D. Adapted from : Stamler; Diabetes Care,12,573 (1989) Cholesterol. Smoking. Hypertension .
Heart Attack Equal risk An attack survivor A typical Type 2 diabetic Without heart problem
Atherosclerosis in T 2 DM ,[object Object],[object Object],[object Object],[object Object],National Diabetes Data Group.  Diabetes in America.  2nd ed. NIH;1995.
Death after MI Herlitz J et al, Acta Med Scand 1988
Managing Diabetes  :  4  Cardinal Rules for the Patient ,[object Object],3.  Take your medication  4. Test your blood glucose regularly

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Diabetes And Heart

  • 2. Conventional Cardiac risk factors… superimposed on the diabetic state … Hypertension Microalbuminuria Inactivity South Asian origin Dyslipidaemia Obesity … further accentuate atherosclerosis in the diabetic state…accounting for the excess Cardiac risk
  • 3.
  • 4.  
  • 5. Heart Attack Which patient is at greater risk of future attack? An attack survivor A typical Type 2 diabetic
  • 6. Risk Factors and C.H.D. Adapted from : Stamler; Diabetes Care,12,573 (1989) Cholesterol. Smoking. Hypertension .
  • 7. Heart Attack Equal risk An attack survivor A typical Type 2 diabetic Without heart problem
  • 8.
  • 9. Death after MI Herlitz J et al, Acta Med Scand 1988
  • 10.