1) Recent advances in tablet formulation include new techniques like 3D printing for layered tablets, melt granulation, and foam granulation. 2) New types of tablets have been developed like mouth dissolving tablets, microtablets, and fast-melting tablets using plastic granules. 3) Automation of tablet production equipment and new tablet printing machines that can print up to 750,000 tablets per hour with in-line verification have also been introduced.

1. Recent advances in
tablet
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2. Recent advances in
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Tablet formulation
New techniques
Recent equipments
New polymers
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3. Tablet Formulation
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Mouth Dissolving Tablet
Microtablet
Fast-melting Tablets Based On Highly Plastic
Granules
3-dimensional Printing Technology In Tablet
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4. Mouth dissolving tablet
Chatap V.K ,gupta R.D ,jaiswal N.R, M.P India oct 2007 .
This tablet fast disintegrates when placed on
tongue.release the drug that dissolve in
saliva.
 Also known as orodispersible,fast
disintegrating,rapiment,porous tablet.
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5. Mouth dissolving tablet
Techniques:
 Freeze drying
 Moulding
 Sublimation
 Spray drying
 Direct compression
 Wet granulation
 Dry granulation
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6. Mouth dissolving tablet:
Patented technology:
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Zydus technology
Durasolve technology
Orasolve technology
Flash dose technology
Sheaform technology
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Ceform technology
Wowtab technology
Flashtab technology
Cotton candy
technology
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7. Microtablet
Gul Majid khan ,DOP ,Pakistan.
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Prepared by wet granulation method.
Hydrophillic matrix was formed with xanthin
gum,karaya gum,HPMC together with a
choice of additives from Lactose,avicel PH
101,Talc & Lubritab.
Multiunit dosage form obtained by
encapsulating the mini matrix tablet into hard
gelatin capsule.
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8. Fast-melting tablets
Yourong Fua, Seong Hoon Jeongb and Kinam Parkb, aAkina Inc., 1291
Cumberland Ave., West Lafayette, IN 47906, USA, 2 November 2005.
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Highly plastic granules that can be compressed into tablets at
low pressure were developed to make fast-melting tablets
(FMTs) by compression method.
The highly plastic granules are composed of three components
highly plastic
granules
plastic material
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material enhancing
water penetration
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Wet binder
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9. 3-Dimensional Printing technology in
tablet
Chee Kong Lai,1 Wendy E. Katstra,1Department of Materials Science and
Engineering, Massachusetts Institute of Technology, Cambridge, MA
02139: January 27, 2004
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A system using light-induced fluorescence (LIF)
technology was developed for rapid and
nondestructive analysis of active pharmaceutical
ingredients on tablet surfaces.
Non homogeneous tablets with defined layer of
active ingredients were made by 3-Dimensional
Printing technology to determine penetration depths
of the light source and the resultant fluorescence
responses.
The LIF method of analysis showed penetration to
depths of up to 3 mm into tablets.
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10. 3-Dimensional Printing technology in
tablet
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A correlation between LIF signals from analysis of
tablet surfaces and the total drug content of the
respective tablets was established.
This method of surface analysis was verified with UV
spectrometric methods.
The use of on-line monitoring of the individual tablet
for surface content up to 3000 tablets a minute.
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11. Recent Advancement in
Granulations
http//www.pharmapedia.com
Steam Granulation
 Melt Granulation
 Moisture Activated Dry Granulation
 Thermal Adhesion Granulation Process
 Foam Granulation
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12. Steam Granulation
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It is modification of wet granulation. Here steam is
used as a binder instead of water.
Its several benefits includes higher distribution
uniformity, higher diffusion rate into powders, more
favourable thermal balance during drying step.
Processing time is shorter therefore more number of
tablets are produced per batch.
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13. Melt Granulation /
Thermoplastic Granulation
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Here granulation is achieved by the addition of
meltable binder.
That is binder is in solid state at room temperature but
melts in the temperature range of 50 – 80˚C.
There is no need of drying phase.
Producing SR granulation or solid dispersion.
Polyethylene Glycol (PEG) is used as melting
binders. When water insoluble binders are needed.
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14. Moisture Activated Dry Granulation
(MADG)
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It involves minimal moisture addition, distribution and
agglomeration.
No drying step is required.
Water distribution is via high shear mixer, or low-shear mixer
with highly atomized water spray.
Better content uniformity than direct compression.
Excess moisture is absorbed by hydrophilic polymers such as
cellulose or silica added to the moist pre-blend.
Applicable to controlled release.
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15. Thermal Adhesion Granulation
Process (TAGP)
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It is applicable for preparing direct tableting
formulations.
TAGP is performed by subjecting a mixture
containing excipients to heating at a temperature in
the range from about 30ºC to about 130ºC in a closed
system under mixing by tumble rotation until the
formation of granules.
It provides granules with good flow properties and
binding capacity to form tablets of low friability,
adequate hardness and have a high uptake capacity
for active substances whose tableting is poor.
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16. Foam Granulation
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Here liquid binders are added as aqueous foam.
useful for granulating water sensitive formulations,
Reduces drying time
Reduce manufacturing time, less binder required for
Immediate Release (IR) and Controlled Release (CR)
formulations.
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17. Recent Coating Techniques
Electrostatic coating
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Dry coating
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18. Electrostatic dry powder coating for
Immediate release
Eur J Pharm Biopharm. 2010 Jun 19. Qiao M ,Zhang L, Ma Y,Zhu J ,Chow K.
University of Western Ontario, canada
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Developed electrostatic dry powder coating in a pan
coater system.
Two immediate release coating compositions
Opadry(R) AMB and Eudragit(R) EPO were
successfully applied using this process.
A liquid plasticizer was sprayed onto the surface of
the tablet cores to increase the conductivity of tablet
cores to enhance particle deposition,
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19. Electrostatic dry powder coating for
Immediate release
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The application of liquid plasticizer was followed by
spraying charged coating particles using an
electrostatic charging gun to enhance the uniform
deposition on tablet surface.
The coating particles were coalesced into a thin film
by acceptable processing temperature as formation
was confirmed by SEM micrographs.
The results also show coating process produces
tablets with smooth surface.
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20. Dry coating in a rotary fluid bed
Caroline Désirée Kablitz , a, Kim Hardera, and Nora Anne
Urbanetza a Institute of Pharmaceutics, Germany 14 November
2005.
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A highly efficient dry coating process was developed
to obtain an enteric film avoiding completely the use
of organic solvents and water.
Using hydroxypropyl methylcellulose acetate
succinate (HPMCAS) an enteric coat should be
obtained without adding talc as anti-tacking agent
because of problems arising from microbiological
contamination..
The process was conducted in the rotary fluid bed .
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21. Dry coating in a rotary fluid bed
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The determined coating efficiency of the talcfree formulation was high with 94% and
storage stability regarding tacking could be
achieved using colloidal silicon dioxide as top
powder.
coating process in rotary fluid bed. serious
alternative to conventional solvent or water
based coating processes.
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22. Automated Equipment
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Currently several supplier of equipment are develop
and introducing automated system which not only
monitor & control each important parameter but
integrate the controls so that a change in one
condition cause a corrective or compensating action
in the system.
If change is critical the system shut itself down.
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23. Automated Equipment
Automated Equipment attached to each other.
SIFTER
AUTOMATI
C
RMG
CO-MILL
DISCHARGE BOWL/FBD
BOWL

24. Automated Equipment
MANUAL
FBD BOWL
FBD
{RECIPE
SET}
AUTOMATI
C
BLENDER
COMPRESSION
MACHINE

25. Automated Equipment
COMPRESSION MACHINE
AUTOMATI
C
BLISTER/STRIP MACHINE
CARTON
AUTOFILL
MANUA
L
SHIPPER

26. Automated Equipment
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27. New non contact firm grip handler new
tablet printing machine
Purto rico,NY javits apr 2007 newyork
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Its capable printing of clear quality character
number,bar codes,logos ,data on tablet.
Its capable of 250-750,000 tablets per hour.
100% vision product verification camera
station is an automated.
Computerized control is integrated with a 21
CFR part 11.
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28. NEW POLYMERS
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AQUA ZEIN
HYDROXYPROPYL
DERIVATIVE
FG 90 CHITOSAN
EUDRAGIT
International Journal of Pharmaceutics
Volume 377, Issues 1-2, 30 July 2009, Pages 1201-2,
127
Disintegrating material
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CYCLODEXTRIN
MALTODEXTRIN
CORNSTARCH
ALGINIC ACID
METHOCEL®
STARCH-AGAR
MIXTURE
VEEGUM® HV
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