Glycosylation II
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Proteins are very important molecules in our cells . They are involved in virtually all cell functions. Each protein within the body has a specific function. Some proteins are involved in structural support, while others are involved in bodily movement, or in defense against germs. Proteins vary in structure as well as function. They are constructed from a set of 20 amino acids and have distinct three-dimensional shapes.
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Glycosylation II
- 1. 3/8/2015 1 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga
- 2. 2 Glycosylation Tanta University Faculty of Pharmacy HINT-WG Made By: Amira Khaled Rasha Khaled Asmaa Alkhawaga 3/8/2015
- 3. 3 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga Introduction https://www.youtube.com/watch?v=suN-sV0cT6c 3/8/2015
- 4. 4 Glycosylation Proteins are very important molecules in our cells. They are involved in virtually all cell functions. Each protein within the body has a specific function. Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga Introduction http://biology.about.com/od/molecularbiology/a/aa101904a.htm 3/8/2015
- 5. 5 Glycosylation Introduction Antibodie s Contractil e Proteins Enzymes Structural Proteins Hormonal Proteins Storage Proteins Transport Proteins Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga http://biology.about.com/od/molecularbiology/a/aa101 904a.htm 3/8/2015
- 6. 6 Glycosylation Amino acids - The protein building blocks Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga Introduction http://proteinas.guru/img/proteinas/articles/estructura-aminoacido.png 3/8/2015
- 7. 7 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga http://www.geneinfinity.org/sp/sp_aaprops.html 3/8/2015
- 8. 8 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga Levels of protein structure Primary structure Secondary structure Tertiary structure Quaternary structure 3/8/2015
- 9. 9 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga Introduction http://faculty.etsu.edu/millerh/workshop/geneticcode.htm 3/8/2015
- 10. 10 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga Protein synthesis https://www.facebook.com/video.php?v=619630998180835&set=vb.513153435495259&type=2 &theater 3/8/2015
- 11. 11 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga http://www.pro teinsynthesis.or g/what-is- protein- synthesis/ 3/8/2015
- 12. 12 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga https://www.youtube.com/watch?v=l4wgREG-DJ0 3/8/2015
- 13. 13 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga http://www.fmp- berlin.info/de/research/molekula re-physiologie-und- zellbiologie/research- groups/schuelein/researchinteres tsproteintraffic.html 3/8/2015
- 14. 14 Glycosylation Post-translational modification PTM is the chemical modification of a protein after its translation. Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga http://en.wikipedia.org/wiki/Posttranslational_modificatio n 3/8/2015
- 15. 15 Glycosylation Post-translational modification Modification involving peptide bonds Modification of amino acids Protein folding Subunit aggregation Acetylation ADP-ribosylation Carboxylation Glycosylation Fatty Acylation Hydroxylation Methylation Phosphorylation Prenylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga http://www.slideshare.net/srnsankar/protein-glycosylation-and-its-associated- disorders?qid=4a5fa0c4-119b-4b01-b689-7c3cade845c5&v=default&b=&from_search=4 3/8/2015
- 16. 16 Glycosylation Glycosylation Glycan Protein enzymes glycoprotein Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga http://en.wikipedia.org/wiki/Glycosylation proteoglycan 3/8/2015
- 17. 17 Glycosylation Glycoprotein Proteoglycan Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga 3/8/2015
- 18. 18 Glycosylation Five classes of glycans are produced: N-linked glycans O-linked glycans C-linked glycans phospho- glycans Glypiation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga Types of Glycosylation 3/8/2015
- 19. 19 Made By: Asmaa Alkhawaga Glycosylation3/8/2015 Types of Glycosylation
- 20. 3/1/2015 20 Made By: Asmaa Alkhawaga Glycosylation Aglycosylation, is a feature of engineered antibodies to bypass glycosylation.
- 21. 21 Glycosylation Purpose Folding correctly Stability to avoid degrades cell-cell adhesion Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga 3/8/2015
- 22. 22 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga 3/8/2015
- 23. 23 Glycosylation Glycan Protein Glycationenzymes Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga http://en.wikipedia.org/wiki/Glycosylation 3/8/2015
- 24. 24 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga http://en.wikipedia.org/wiki/Advanced_glycation_end-product Advanced Glycation End-product AGEs are substances that can be a factor in the development of many degenerative diseases, such as diabetes, atherosclerosis, chronic renal failure, and Alzheimer's diseases erythropoiesis. 3/8/2015
- 25. 25 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga http://circ.ahajournals.org/content/114/6/597/F1.expansion.html 3/8/2015
- 26. 26 Glycosylation Mechanism The most complex post-translational modification. The donor molecule is often an activated nucleotide sugar. It is a site-specific modification. Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga 3/8/2015
- 27. 27 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga http://plantphys.info/ plant_physiology/basic cytology1.shtml 3/8/2015
- 28. 28 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga N-linked glycosylation The attachment of a sugar molecule to a nitrogen of aspara- gine or arginine side chains. requires participation of dolichol phosphate http://en.wikipedia.org/wiki/N- linked_glycosylation 3/8/2015
- 29. 29 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga http://en.wikipedia.org/wiki/N-linked_glycosylation N-linked glycosylation 3/8/2015
- 30. 30 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga 3/8/2015
- 31. 31 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga O-linked glycosylation The attachment of a sugar molecule to an oxygen atom in an amino acid residue in a protein. dolichol phosphate is not involved. 3/8/2015
- 32. 32 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga 3/8/2015
- 33. 33 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga https://www.youtube.com/watch?v=RorGifz6C2Y 3/8/2015
- 34. 34 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga Fertilization Erythropoietin Blood groups lymphocyte movement Glycoproteinsare involvedin many biological process… 3/8/2015
- 35. 35 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga Fertilization http://csls-text.c.u- tokyo.ac.jp/active/12_07.html 3/8/2015
- 36. 36 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga Erythropoietin EPO It is a glycoprotein hormone produced by kidney that controls erythropoiesis. It is about 165 amino acids; • N glycosylated to 3 asp residue. • O glycosylated on ser residue. http://en.wikipedia.org/wiki/Erythropoietin 3/8/2015
- 37. 37 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga • Eprex® is synthetic erythropoietin (epoetin alfa) and is used to replace the erythropoietin. http://chealth.canoe.ca/drug_info_detai ls.asp?brand_name_id=1174 3/8/2015 Erythropoietin EPO
- 38. 38 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga Blood groups 3/8/2015
- 39. 39 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga http://www.glycoforum.gr.jp/scienc e/hyaluronan/HA32/HA32E.html Actin ligand interaction in lymphocyte movement 3/8/2015
- 40. 40 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga Disorders Diseases Cancer Congenital disorder of glycosylation leukocyte adhesion deficiency type 2 leukocyte adhesion deficiency type 2 paroxysmal nocturnal hemoglobinuria Cell disease 3/8/2015
- 41. 41 Glycosylation Congenital disorder of glycosylation Autosomal recessive disorder. Especially affect the nervous system, muscles and intestines in affected infants. Result in psychomotor retardation. Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga http://www.slideshare.net/srnsankar/protein- glycosylation-and-its-associated- disorders?qid=4a5fa0c4-119b-4b01-b689- 7c3cade845c5&v=default&b=&from_search=4 3/8/2015
- 42. 42 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga Type I disorder http://disorders.eyes.arizona.edu/dis orders/congenital-disorder- glycosylation-type-ij 3/8/2015
- 43. 43 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga Type II disorder http://www.nature.com/nm/journal/v10 /n5/fig_tab/nm0504-457_F1.html 3/8/2015
- 44. 44 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga http://www.raysahelian.com/carnosine.html carnosine L-Carnosine is naturally produced in the body by the enzyme carnosine synthetase. This nutrient supports healthy aging and cellular rejuvenation. 3/8/2015
- 45. 45 Glycosylation Made By: Amira Khaled & Rasha Khaled and Asmaa Alkhawaga 3/8/2015