Biotechnology Industry has changed a lot during last decade , which means moving ahead from traditional ways to more advanced technological developments 2012 Biotechnology Industry is not the same as it was in 2001

1. Choosing a Career path in 21st Century without understanding the Industry
would be as good as ship sailing in a sea without a compass
Biotechnology is the research and development of innovative
healthcare, agricultural, industrial and environmental products
by
BioInformaticsOnRun
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2. YOUR APPROACH YOUR DECISION YOUR
PASSION
 Drug Discovery R&D Organizations
 SYSTEM Biology Companies
 Informatics Knowledgebase Development firms
 Clinical Research Organizations
 Seed technology and genetically modified food
 Biofuels
 Monoclonal Antibodies
 Environmental and industrial biotechnology
 Instrumentation and Equipment
 Out Look
 How to Approach
Heal the Feed the
World Fuel the world World

3. Biology Informatics and Research and development Challenges
PhD Students ,Postdoctoral
That’s an Impressive Researchers
introduction and I know ,Professors/Lecturers, Masters
Students , Librarians, Commercial
the PROBLEMS AND R&D Professionals
CHALLENGES you ,Undergraduates, Academic
Researchers Government /NGO
CURRENTLY FACING researchers
Systems
Biology
The Slides will help you to understand the mechanism , workflows , and
Process of different segments in life science Industry

4. Drug Discovery Science
This all Started when you try to
understand the disease
Target Identification
(Choose a molecule to
target with a drug)
When you try to understand
Target validation
how the gene are altered
(Test the Target and
Confirm its role in
Diseases)
How that affects the proteins Drug Discovery
they encode (Find a promising Molecule
(“ a Lead compound”) that
could become a drug)
And how these proteins Interact Early Safety Test
with each other in living cells Perform Initial Tests on
Promising Compounds
Lead optimization
How those affected cell change (Alter the Structure of Lead
the specific tissue they are in Candidates to improve
Properties)
And finally how the diseases
affects the entire patient

5. Today Scientists are facing More Challenges
Biological
network maps
Complexity of
biological
system
Produce better
small molecules
at early drug
discovery
stages
Visualization
Storage ,
retrieval and
Time and Cost analysis of data

6. Systems Biology as Savior
Omics
Molecular Pathway Regulatory Networks
Whole Cells
Organism Systems
Biology
Organs Tissues
Modeling

7. Gene translation
Protein Expression
Signaling Event
Genomics
Metabolite Fluxes Cell
Identify nodes of signaling networks
Identification of Interaction Partners
and Protein Modifications
Knockout Knock In Genes
Proteomics
MODELING
OMICS
Tissue
Epigenomics
Review of Quantitative models of the
System from gene to Physiology
Review of approaches for modeling
Metabolites diseases Organ
Computationally –based Complexity
mathematical model of disease
predicts patient responses to
different therapies

8. Methods to Study Proteins
Determining Establishing
proteins which are Protein- Protein
post translationaly interactions
modified
Computational
Determining the
methods in
existence of
studying protein
proteins in
biomarkers
complex mixtures
Detecting Protein Protein Protein-DNA Protein
Proteins Purification Structures Interactions Curation

9. Informatics Science
Literature Informatics
Imaging Informatics
Clinical Informatics
Public health Informatics
Literature Informatics
Publications of databases of biological information
Microarray datasheets
High Throughput Screening datasets
Other Experimental Data
Well Developed
Chemistry Skills
capable of
offering end to
Establishing Skills end complex
in basic molecular capabilities
biology and
protein
Expression

10. CLINICALLY APPROVED DRUGS
Phase 0
Phase1
Pre- Clinical
Phase
Phase 2
Phase 3
Post
marketing
surveillance
Trial
Translational
research

11. GM CROPS /FOOD/SEEDS
Why are GM food/Crops produced and
Developed????
 Improve crop Protection
 Insect resistance
 Virus resistance
 Herbicide tolerance
 The safety assessment of GM foods
 Allergenicity
 Gene Transfer
 Outcrossing
Examples:
 Drought tolerant Maize
 Protecting Plants against Freezing
 Apple genome sequencing
 Longer shelf life for tomatoes
Biofuels: Ethanol from Biomass

12. DIFFERENT ROLES TO PLAY IN BIOTECHNOLOGY INDUSTRY
Monoclonal
Antibodies Market
Large protein molecules
produced by white blood
cells that seek out and
destroy harmful foreign
substances
Application in many areas
of medicine and biologic
science
Are used in the
identification of organisms
in the bacteriology
laboratory
Also used in the diagnosis
of leukemia
Used in the treatment of
malignancies

13. ENVIRONMENTAL/INDUSTRIAL BIOTECHNOLOGY MARKET
Cells can be Production of
Living cells and
Use of modified to chemicals, pestici
Enzymes can be
microorganisms produce des, biofuels and
used to produce
or biological enzymes, which biodegradable
vitamins,
substances to function plastics made
antibiotics,
perform specific biologically as from renewable
vaccines and
industrial or catalysts to bring raw materials like
proteins for
manufacturing about specific starch, vegetable
medicinal
process biochemical oils, cellulose and
purposes
reaction agricultural waste.

14. INSTRUMENTATION & EQUIPMENT MARKET
Instrumentation would refer to large-scale equipment such as
MRI machines, ultrasound machines, immunoanalyzers and
hemoanalyzers.
Devices used for surgery, such as laparascopes, endoscopes
and arthoscopes. Durable equipment or DME such as medical
beds or chairs, wheelchairs and canes would be part of this
category.
DNA sequencers and high throughput screeners. Mass
spectrometers are currently used for a variety of clinical
applications. Mass spectrometry (MS) is an assessment
technology that identifies the mass-to-charge ratio of charged
particles

15. OUTLOOK
 Mapping of the human genome
 Wave of new biologic drug product approvals by the FDA.
Therapeutic areas offer the best investment
opportunities
Regenerative medicine
Opthalmology
Oncology
Infectious disease
Metabolic
Genetic disorders
0% 20% 40% 60% 80%
Source::http://thomsonreuters.com/content/science/pdf/white_papers/BIO_ThomsonReuters09_study.pdf

16. Q. I Know Industry How to approach ?
Proper Education : To
Masters of Science
excel in biotechnology
,Masters in
Industry you need to Have focused approach
technology, PhD is
have good educational
Preferred
background
Additional short course
Know your Interest Remember Experience
Projects and Industry
/Develop Interest is advantage
Project is Preferred
Keep track of Industry
, follow trends ,Select
Path

17. CONCLUSION
 Biotechnology Industry has changed a lot during last decade , which means
moving ahead from traditional ways to more advanced technological
developments
 2012 Biotechnology Industry is not the same as it was in 2001
 Computational, Mathematics and physics knowledge additions to Biology has
opened many new windows for Investors and for Small and Mid-Sized
Entrepreneurs which again playing very important role .
 Many Students with Diversified Non- life science background are working for
this Industry
 Companies are investing more and more in Lethal Diseases which is a good
sign for the Industry and the society as whole
 FDI and Government policies too play a very important role and need to be
regularly monitored by anyone who want to have a career in Life science
Industry

18. Thank YOU
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