SlideShare una empresa de Scribd logo

Introduction To Drug Discovery

•Descargar como PPT, PDF•
•
ubio Biotechnology Systems Pvt Ltd
ubio Biotechnology Systems Pvt Ltd

an introduction to drug discovery

TecnologíaEmpresariales
1 de 42
HERBAL AND DRUG DESIGN TECHNOLOGY Selma Siyavudeen
(IUPAC Recommendations 1997) ,[object Object],[object Object]
The process of drug discovery ,[object Object],[object Object],[object Object]
Drug discovery / design - steps IDENTIFICATION OPTIMISATION DEVELOPMENT FINDING A LEAD COMPOUND / NCE QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS, ASSAYS – in vitro and in vivo PHARMACOKINETIC STUDIES TOXICOLOGY TESTING FORMULATION DEVELOPMENT CLINICAL TRIALS REGULATORY APPROVAL LEAD
Drug design (ligand design) ,[object Object],[object Object],[object Object],[object Object],[object Object]
sources of lead compounds ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
An Example of CADD: Carbonic anhydrase ,[object Object],[object Object],[object Object],[object Object]
[object Object]
CADD Advantages & Limitations ,[object Object],[object Object],[object Object],[object Object]
STEP II LEAD OPTIMISATION ,[object Object]
Synthesis of homologues and analogues from a prototype ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
design of variants ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
QSAR ,[object Object],[object Object]
QSAR ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Step iii Lead Development ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Animal pharmacokinetic studies ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Toxicity testing
Formulation development ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical trials
REVOLUTIONS IN DRUG DESIGN technology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Advances in molecular biology-newer targets for drugs ,[object Object],[object Object],[object Object],[object Object]
Advances in recombinant DNA technology - biopharmaceuticals ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Advances in genomics & Microarray Technology Drug development Tracking disease progression Disease risk assessment Genotyping Drug development Drug response Tracking disease progression Therapy development Drug mechanism of action Applications Detect mutations/polymorphisms Analysis of gene expression levels Breif description Mutation/polymorphism analysis Expression analysis Microarray type
Herbal drug design ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Historical perspective anticancer Vinca rosea vincristine anticancer Vinca rosea vincaleukoblastine Hypotensive,tranquilizer rauwolfia reserpine foxflove digitoxin cocaine cinchona quinine opium morphine
What should be the approach? ,[object Object],[object Object],[object Object],[object Object],[object Object]
Fractionation of tumor inhibitory extract ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Recent discoveries Galanthus Woronowii Losinsk . Alzheimer”s disease Galanthamine Artemesia annua L. Antimalarial drug Arteether Taxus brevifolia Nutt. Camptotheca acuminata Decne. Catharanthus roseus G.Don plant Anticancer agents properties Paclitaxel Camptothecin Vinflunine Drug
Papaver somniferum L. Pain medication Morphine 6-gluconoride Calophyllum lanigerum var. austrocoriaceum Atropa belladona L. Anti HIV drugs antiretroviral and anti mycobacterial agent , n on-nucleoside reverse transcriptase inhibitor of type 1 HIV Effective against AZT resistant strains of HIV Chronic obstructive pulmonary disease inhaled bronchodialator Calanolide A Tiotropium
NCE s from India Coleus forskohlii Briq. Dysoxylum binectariferum Hook. Potent adenylate cyclase activator Semisynthetic derivative is approved for treatment of glaucoma tyrosine kinase activity and potent growth inhibitory activity against breast and lung carcinoma cell lines. Forskolin Flavopiridol
Commiphora mukul (Stocks)Engl. Lowers serum LDL and triglyceride levels highly efficacious antagonist of FXR (farnesoid X receptor) Guggulsterone, [4,17,(20)-pregnadiene-3,16-dione]
Herbal product development ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
DNA Microarray - applications
Microarray-based gene expression analysis of multi-component mixtures.
[object Object],[object Object],[object Object]
[object Object],[object Object]
Conclusion ,[object Object],[object Object]
[object Object]

Recomendados

Pharmacophore
PharmacophorePharmacophore
Pharmacophoresachin panwar
 
Structure base drug design
Structure base drug designStructure base drug design
Structure base drug designJayshreeUpadhyay
 
SlideShare on Traditional drug design methods
SlideShare on Traditional drug design methods SlideShare on Traditional drug design methods
SlideShare on Traditional drug design methods Naveen K L
 
Traditional and Rational Drug Designing
Traditional and Rational Drug DesigningTraditional and Rational Drug Designing
Traditional and Rational Drug DesigningManish Kumar
 
3d qsar
3d qsar3d qsar
3d qsarMahendra G S
 
Presentation on concept of pharmacophore mapping and pharmacophore based scre...
Presentation on concept of pharmacophore mapping and pharmacophore based scre...Presentation on concept of pharmacophore mapping and pharmacophore based scre...
Presentation on concept of pharmacophore mapping and pharmacophore based scre...B V V S Hanagal Shri Kumareshwar College of Pharmacy, Bagalkote
 
Pharmacophore modeling
Pharmacophore modelingPharmacophore modeling
Pharmacophore modelingDevika Rana
 
Computer aided drug design
Computer aided drug designComputer aided drug design
Computer aided drug designN K
 

Recomendados

Pharmacophore
PharmacophorePharmacophore
Pharmacophoresachin panwar
 
Structure base drug design
Structure base drug designStructure base drug design
Structure base drug designJayshreeUpadhyay
 
SlideShare on Traditional drug design methods
SlideShare on Traditional drug design methods SlideShare on Traditional drug design methods
SlideShare on Traditional drug design methods Naveen K L
 
Traditional and Rational Drug Designing
Traditional and Rational Drug DesigningTraditional and Rational Drug Designing
Traditional and Rational Drug DesigningManish Kumar
 
3d qsar
3d qsar3d qsar
3d qsarMahendra G S
 
Presentation on concept of pharmacophore mapping and pharmacophore based scre...
Presentation on concept of pharmacophore mapping and pharmacophore based scre...Presentation on concept of pharmacophore mapping and pharmacophore based scre...
Presentation on concept of pharmacophore mapping and pharmacophore based scre...B V V S Hanagal Shri Kumareshwar College of Pharmacy, Bagalkote
 
Pharmacophore modeling
Pharmacophore modelingPharmacophore modeling
Pharmacophore modelingDevika Rana
 
Computer aided drug design
Computer aided drug designComputer aided drug design
Computer aided drug designN K
 
Lead identification
Lead identification Lead identification
Lead identification Vikram Choudhary
 
Rational drug design
Rational drug designRational drug design
Rational drug designNavpreetSingh132
 
RATIONAL AND TRADITIONAL DRUG DESIGN Drug Discovery.pptx
RATIONAL AND TRADITIONAL DRUG DESIGN Drug Discovery.pptxRATIONAL AND TRADITIONAL DRUG DESIGN Drug Discovery.pptx
RATIONAL AND TRADITIONAL DRUG DESIGN Drug Discovery.pptxsakshinalkande
 
drug discovery- history, evolution and stages
drug discovery- history, evolution and stagesdrug discovery- history, evolution and stages
drug discovery- history, evolution and stagesaiswarya thomas
 
Virtual sreening
Virtual sreeningVirtual sreening
Virtual sreeningMahendra G S
 
LEAD IDENTIFICATION BY SUHAS PATIL (S.K.)
LEAD IDENTIFICATION BY SUHAS PATIL (S.K.)LEAD IDENTIFICATION BY SUHAS PATIL (S.K.)
LEAD IDENTIFICATION BY SUHAS PATIL (S.K.)suhaspatil114
 
Genomics and proteomics in drug discovery and development
Genomics and proteomics in drug discovery and developmentGenomics and proteomics in drug discovery and development
Genomics and proteomics in drug discovery and developmentSuchittaU
 
PHARMACOHORE MAPPING AND VIRTUAL SCRRENING FOR RESEARCH DEPARTMENT
PHARMACOHORE MAPPING AND VIRTUAL SCRRENING FOR RESEARCH DEPARTMENTPHARMACOHORE MAPPING AND VIRTUAL SCRRENING FOR RESEARCH DEPARTMENT
PHARMACOHORE MAPPING AND VIRTUAL SCRRENING FOR RESEARCH DEPARTMENTShikha Popali
 
Rational drug design
Rational drug designRational drug design
Rational drug designNaresh Juttu
 
Drug discovery
Drug discoveryDrug discovery
Drug discoverySaba Ahmed
 
Role of Target Identification and Target Validation in Drug Discovery Process
Role of Target Identification and Target Validation in Drug Discovery ProcessRole of Target Identification and Target Validation in Drug Discovery Process
Role of Target Identification and Target Validation in Drug Discovery ProcessPallavi Duggal
 
Traditional drug design
Traditional drug designTraditional drug design
Traditional drug designSanchit Dhankhar
 
drug discovery & development
drug discovery & developmentdrug discovery & development
drug discovery & developmentRohit K.
 
Drug design and discovery ppt
Drug design and discovery pptDrug design and discovery ppt
Drug design and discovery pptDr NEETHU ASOKAN
 
DRUG DISCOVERY & COMPUTER-AIDED DRUG DESIGN
DRUG DISCOVERY & COMPUTER-AIDED DRUG DESIGNDRUG DISCOVERY & COMPUTER-AIDED DRUG DESIGN
DRUG DISCOVERY & COMPUTER-AIDED DRUG DESIGNAshwani Dhingra
 
Virtual screening techniques
Virtual screening techniquesVirtual screening techniques
Virtual screening techniquesROHIT PAL
 
In silico drug desigining
In silico drug desiginingIn silico drug desigining
In silico drug desiginingDevesh Shukla
 
3D QSAR
3D QSAR3D QSAR
3D QSARsuraj wanjari
 
SAR & QSAR
SAR & QSARSAR & QSAR
SAR & QSARBharat Kumar
 
Pharmacophore mapping
Pharmacophore mapping Pharmacophore mapping
Pharmacophore mapping GamitKinjal
 
Research Avenues in Drug discovery of natural products
Research Avenues in Drug discovery of natural productsResearch Avenues in Drug discovery of natural products
Research Avenues in Drug discovery of natural productsDevakumar Jain
 
Drug Design:Discovery, Development and Delivery
Drug Design:Discovery, Development and DeliveryDrug Design:Discovery, Development and Delivery
Drug Design:Discovery, Development and DeliveryProf. Dr. Basavaraj Nanjwade
 

Más contenido relacionado

La actualidad más candente

RATIONAL AND TRADITIONAL DRUG DESIGN Drug Discovery.pptx
RATIONAL AND TRADITIONAL DRUG DESIGN Drug Discovery.pptxRATIONAL AND TRADITIONAL DRUG DESIGN Drug Discovery.pptx
RATIONAL AND TRADITIONAL DRUG DESIGN Drug Discovery.pptxsakshinalkande
 
drug discovery- history, evolution and stages
drug discovery- history, evolution and stagesdrug discovery- history, evolution and stages
drug discovery- history, evolution and stagesaiswarya thomas
 
LEAD IDENTIFICATION BY SUHAS PATIL (S.K.)
LEAD IDENTIFICATION BY SUHAS PATIL (S.K.)LEAD IDENTIFICATION BY SUHAS PATIL (S.K.)
LEAD IDENTIFICATION BY SUHAS PATIL (S.K.)suhaspatil114
 
Genomics and proteomics in drug discovery and development
Genomics and proteomics in drug discovery and developmentGenomics and proteomics in drug discovery and development
Genomics and proteomics in drug discovery and developmentSuchittaU
 
PHARMACOHORE MAPPING AND VIRTUAL SCRRENING FOR RESEARCH DEPARTMENT
PHARMACOHORE MAPPING AND VIRTUAL SCRRENING FOR RESEARCH DEPARTMENTPHARMACOHORE MAPPING AND VIRTUAL SCRRENING FOR RESEARCH DEPARTMENT
PHARMACOHORE MAPPING AND VIRTUAL SCRRENING FOR RESEARCH DEPARTMENTShikha Popali
 
Rational drug design
Rational drug designRational drug design
Rational drug designNaresh Juttu
 
Drug discovery
Drug discoveryDrug discovery
Drug discoverySaba Ahmed
 
Role of Target Identification and Target Validation in Drug Discovery Process
Role of Target Identification and Target Validation in Drug Discovery ProcessRole of Target Identification and Target Validation in Drug Discovery Process
Role of Target Identification and Target Validation in Drug Discovery ProcessPallavi Duggal
 
drug discovery & development
drug discovery & developmentdrug discovery & development
drug discovery & developmentRohit K.
 
Drug design and discovery ppt
Drug design and discovery pptDrug design and discovery ppt
Drug design and discovery pptDr NEETHU ASOKAN
 
DRUG DISCOVERY & COMPUTER-AIDED DRUG DESIGN
DRUG DISCOVERY & COMPUTER-AIDED DRUG DESIGNDRUG DISCOVERY & COMPUTER-AIDED DRUG DESIGN
DRUG DISCOVERY & COMPUTER-AIDED DRUG DESIGNAshwani Dhingra
 
Virtual screening techniques
Virtual screening techniquesVirtual screening techniques
Virtual screening techniquesROHIT PAL
 
In silico drug desigining
In silico drug desiginingIn silico drug desigining
In silico drug desiginingDevesh Shukla
 
Pharmacophore mapping
Pharmacophore mapping Pharmacophore mapping
Pharmacophore mapping GamitKinjal
 

La actualidad más candente (20)

Lead identification
Lead identification Lead identification
Lead identification
 
Rational drug design
Rational drug designRational drug design
Rational drug design
 
RATIONAL AND TRADITIONAL DRUG DESIGN Drug Discovery.pptx
RATIONAL AND TRADITIONAL DRUG DESIGN Drug Discovery.pptxRATIONAL AND TRADITIONAL DRUG DESIGN Drug Discovery.pptx
RATIONAL AND TRADITIONAL DRUG DESIGN Drug Discovery.pptx
 
drug discovery- history, evolution and stages
drug discovery- history, evolution and stagesdrug discovery- history, evolution and stages
drug discovery- history, evolution and stages
 
Virtual sreening
Virtual sreeningVirtual sreening
Virtual sreening
 
LEAD IDENTIFICATION BY SUHAS PATIL (S.K.)
LEAD IDENTIFICATION BY SUHAS PATIL (S.K.)LEAD IDENTIFICATION BY SUHAS PATIL (S.K.)
LEAD IDENTIFICATION BY SUHAS PATIL (S.K.)
 
Genomics and proteomics in drug discovery and development
Genomics and proteomics in drug discovery and developmentGenomics and proteomics in drug discovery and development
Genomics and proteomics in drug discovery and development
 
PHARMACOHORE MAPPING AND VIRTUAL SCRRENING FOR RESEARCH DEPARTMENT
PHARMACOHORE MAPPING AND VIRTUAL SCRRENING FOR RESEARCH DEPARTMENTPHARMACOHORE MAPPING AND VIRTUAL SCRRENING FOR RESEARCH DEPARTMENT
PHARMACOHORE MAPPING AND VIRTUAL SCRRENING FOR RESEARCH DEPARTMENT
 
Rational drug design
Rational drug designRational drug design
Rational drug design
 
Drug discovery
Drug discoveryDrug discovery
Drug discovery
 
Role of Target Identification and Target Validation in Drug Discovery Process
Role of Target Identification and Target Validation in Drug Discovery ProcessRole of Target Identification and Target Validation in Drug Discovery Process
Role of Target Identification and Target Validation in Drug Discovery Process
 
Traditional drug design
Traditional drug designTraditional drug design
Traditional drug design
 
drug discovery & development
drug discovery & developmentdrug discovery & development
drug discovery & development
 
Drug design and discovery ppt
Drug design and discovery pptDrug design and discovery ppt
Drug design and discovery ppt
 
DRUG DISCOVERY & COMPUTER-AIDED DRUG DESIGN
DRUG DISCOVERY & COMPUTER-AIDED DRUG DESIGNDRUG DISCOVERY & COMPUTER-AIDED DRUG DESIGN
DRUG DISCOVERY & COMPUTER-AIDED DRUG DESIGN
 
Virtual screening techniques
Virtual screening techniquesVirtual screening techniques
Virtual screening techniques
 
In silico drug desigining
In silico drug desiginingIn silico drug desigining
In silico drug desigining
 
3D QSAR
3D QSAR3D QSAR
3D QSAR
 
SAR & QSAR
SAR & QSARSAR & QSAR
SAR & QSAR
 
Pharmacophore mapping
Pharmacophore mapping Pharmacophore mapping
Pharmacophore mapping
 

Similar a Introduction To Drug Discovery

Research Avenues in Drug discovery of natural products
Research Avenues in Drug discovery of natural productsResearch Avenues in Drug discovery of natural products
Research Avenues in Drug discovery of natural productsDevakumar Jain
 
Drug design, discovery and development
Drug design, discovery and developmentDrug design, discovery and development
Drug design, discovery and developmentFarzana Sultana
 
Introduction to the drug discovery process
Introduction to the drug discovery processIntroduction to the drug discovery process
Introduction to the drug discovery processThanh Truong
 
Some building blocks for Rational Drug Design
Some building blocks for Rational Drug Design Some building blocks for Rational Drug Design
Some building blocks for Rational Drug Design samthamby79
 
Unc slides on computational toxicology
Unc slides on computational toxicologyUnc slides on computational toxicology
Unc slides on computational toxicologySean Ekins
 
Towards Personalized Medicine
Towards Personalized MedicineTowards Personalized Medicine
Towards Personalized MedicineMichel Dumontier
 
Drug discovery and development
Drug discovery and developmentDrug discovery and development
Drug discovery and developmentSharafudheenKa4
 
Using antitumor agents to probe the sensitivity contexts of cancer cells and ...
Using antitumor agents to probe the sensitivity contexts of cancer cells and ...Using antitumor agents to probe the sensitivity contexts of cancer cells and ...
Using antitumor agents to probe the sensitivity contexts of cancer cells and ...Laura Berry
 
Drug discovery process.
Drug discovery process.Drug discovery process.
Drug discovery process.borude123
 
Bioinformatics t9-t10-biocheminformatics v2014
Bioinformatics t9-t10-biocheminformatics v2014Bioinformatics t9-t10-biocheminformatics v2014
Bioinformatics t9-t10-biocheminformatics v2014Prof. Wim Van Criekinge
 
Treatment of breast cancer by TDDS
Treatment of breast cancer by TDDSTreatment of breast cancer by TDDS
Treatment of breast cancer by TDDSRaman Deep
 
Session 1 part 3
Session 1 part 3Session 1 part 3
Session 1 part 3plmiami
 
Bioanalysis significance 12 oct 2022.ppt
Bioanalysis significance 12 oct 2022.pptBioanalysis significance 12 oct 2022.ppt
Bioanalysis significance 12 oct 2022.pptDr. Manoj Kumbhare
 
Metabolic engineering approaches in medicinal plants
Metabolic engineering approaches in medicinal plantsMetabolic engineering approaches in medicinal plants
Metabolic engineering approaches in medicinal plantsN Poorin
 
A Systematic Review and Meta-Analysis of Plant cell technology for Production...
A Systematic Review and Meta-Analysis of Plant cell technology for Production...A Systematic Review and Meta-Analysis of Plant cell technology for Production...
A Systematic Review and Meta-Analysis of Plant cell technology for Production...Pubrica
 

Similar a Introduction To Drug Discovery (20)

Research Avenues in Drug discovery of natural products
Research Avenues in Drug discovery of natural productsResearch Avenues in Drug discovery of natural products
Research Avenues in Drug discovery of natural products
 
Drug Design:Discovery, Development and Delivery
Drug Design:Discovery, Development and DeliveryDrug Design:Discovery, Development and Delivery
Drug Design:Discovery, Development and Delivery
 
Drug discovery anthony crasto
Drug discovery anthony crastoDrug discovery anthony crasto
Drug discovery anthony crasto
 
Drug design, discovery and development
Drug design, discovery and developmentDrug design, discovery and development
Drug design, discovery and development
 
Introduction to the drug discovery process
Introduction to the drug discovery processIntroduction to the drug discovery process
Introduction to the drug discovery process
 
Some building blocks for Rational Drug Design
Some building blocks for Rational Drug Design Some building blocks for Rational Drug Design
Some building blocks for Rational Drug Design
 
Computer Aided Drug Design
Computer Aided Drug DesignComputer Aided Drug Design
Computer Aided Drug Design
 
Drug discovery hit to lead
Drug discovery hit to leadDrug discovery hit to lead
Drug discovery hit to lead
 
Unc slides on computational toxicology
Unc slides on computational toxicologyUnc slides on computational toxicology
Unc slides on computational toxicology
 
Towards Personalized Medicine
Towards Personalized MedicineTowards Personalized Medicine
Towards Personalized Medicine
 
Drug discovery and development
Drug discovery and developmentDrug discovery and development
Drug discovery and development
 
Using antitumor agents to probe the sensitivity contexts of cancer cells and ...
Using antitumor agents to probe the sensitivity contexts of cancer cells and ...Using antitumor agents to probe the sensitivity contexts of cancer cells and ...
Using antitumor agents to probe the sensitivity contexts of cancer cells and ...
 
Drug discovery process.
Drug discovery process.Drug discovery process.
Drug discovery process.
 
Bioinformatics t9-t10-biocheminformatics v2014
Bioinformatics t9-t10-biocheminformatics v2014Bioinformatics t9-t10-biocheminformatics v2014
Bioinformatics t9-t10-biocheminformatics v2014
 
Treatment of breast cancer by TDDS
Treatment of breast cancer by TDDSTreatment of breast cancer by TDDS
Treatment of breast cancer by TDDS
 
Opensourcepharma Dr Nibedita rath
Opensourcepharma Dr Nibedita rathOpensourcepharma Dr Nibedita rath
Opensourcepharma Dr Nibedita rath
 
Session 1 part 3
Session 1 part 3Session 1 part 3
Session 1 part 3
 
Bioanalysis significance 12 oct 2022.ppt
Bioanalysis significance 12 oct 2022.pptBioanalysis significance 12 oct 2022.ppt
Bioanalysis significance 12 oct 2022.ppt
 
Metabolic engineering approaches in medicinal plants
Metabolic engineering approaches in medicinal plantsMetabolic engineering approaches in medicinal plants
Metabolic engineering approaches in medicinal plants
 
A Systematic Review and Meta-Analysis of Plant cell technology for Production...
A Systematic Review and Meta-Analysis of Plant cell technology for Production...A Systematic Review and Meta-Analysis of Plant cell technology for Production...
A Systematic Review and Meta-Analysis of Plant cell technology for Production...
 

Más de ubio Biotechnology Systems Pvt Ltd

Más de ubio Biotechnology Systems Pvt Ltd (20)

UBIO PROJECT TRAINING
UBIO PROJECT TRAININGUBIO PROJECT TRAINING
UBIO PROJECT TRAINING
 
ubio Human Diagnostics
ubio Human Diagnosticsubio Human Diagnostics
ubio Human Diagnostics
 
sensit Rapid tests
sensit Rapid testssensit Rapid tests
sensit Rapid tests
 
ubio New Catalog
ubio New Catalogubio New Catalog
ubio New Catalog
 
ubio sensit Filariasis Antibody rapid test
ubio sensit Filariasis Antibody rapid testubio sensit Filariasis Antibody rapid test
ubio sensit Filariasis Antibody rapid test
 
Sensit MPT 64 TB Antigen rapid test
Sensit MPT 64 TB Antigen rapid testSensit MPT 64 TB Antigen rapid test
Sensit MPT 64 TB Antigen rapid test
 
Ubio catalogue
Ubio catalogueUbio catalogue
Ubio catalogue
 
Canine Parvovirus Rapid Test
Canine Parvovirus Rapid TestCanine Parvovirus Rapid Test
Canine Parvovirus Rapid Test
 
Biotechnology Industry in Kerala: a View from the Trenches
Biotechnology Industry in Kerala: a View from the TrenchesBiotechnology Industry in Kerala: a View from the Trenches
Biotechnology Industry in Kerala: a View from the Trenches
 
Biotechnology Industry in Kerala: A view from the Trenches
Biotechnology Industry in Kerala: A view from the TrenchesBiotechnology Industry in Kerala: A view from the Trenches
Biotechnology Industry in Kerala: A view from the Trenches
 
ubio Veterinary Test Product List
ubio Veterinary Test Product Listubio Veterinary Test Product List
ubio Veterinary Test Product List
 
Ubio vet pregnancy_kit_technical_bulletin
Ubio vet pregnancy_kit_technical_bulletinUbio vet pregnancy_kit_technical_bulletin
Ubio vet pregnancy_kit_technical_bulletin
 
Pregnancy test in cow
Pregnancy test in cowPregnancy test in cow
Pregnancy test in cow
 
Canine Coronavirus Infection
Canine Coronavirus InfectionCanine Coronavirus Infection
Canine Coronavirus Infection
 
lateral flow assays
lateral flow assayslateral flow assays
lateral flow assays
 
Fmd control strategies in kerala
Fmd control strategies in keralaFmd control strategies in kerala
Fmd control strategies in kerala
 
Foot and Mouth Disese control strategies
Foot and Mouth Disese control strategiesFoot and Mouth Disese control strategies
Foot and Mouth Disese control strategies
 
Biology for Computer Engineers, Part 2: The Cell
Biology for Computer Engineers, Part 2: The CellBiology for Computer Engineers, Part 2: The Cell
Biology for Computer Engineers, Part 2: The Cell
 
Making of a Veterinarian
Making of a VeterinarianMaking of a Veterinarian
Making of a Veterinarian
 
Biology for Computer Engineers:Part 1(www.ubio.in)
Biology for Computer Engineers:Part 1(www.ubio.in)Biology for Computer Engineers:Part 1(www.ubio.in)
Biology for Computer Engineers:Part 1(www.ubio.in)
 

Último

SIP trunking in Janus @ Kamailio World 2024
SIP trunking in Janus @ Kamailio World 2024SIP trunking in Janus @ Kamailio World 2024
SIP trunking in Janus @ Kamailio World 2024Lorenzo Miniero
 
"Debugging python applications inside k8s environment", Andrii Soldatenko
"Debugging python applications inside k8s environment", Andrii Soldatenko"Debugging python applications inside k8s environment", Andrii Soldatenko
"Debugging python applications inside k8s environment", Andrii SoldatenkoFwdays
 
Streamlining Python Development: A Guide to a Modern Project Setup
Streamlining Python Development: A Guide to a Modern Project SetupStreamlining Python Development: A Guide to a Modern Project Setup
Streamlining Python Development: A Guide to a Modern Project SetupFlorian Wilhelm
 
DevoxxFR 2024 Reproducible Builds with Apache Maven
DevoxxFR 2024 Reproducible Builds with Apache MavenDevoxxFR 2024 Reproducible Builds with Apache Maven
DevoxxFR 2024 Reproducible Builds with Apache MavenHervé Boutemy
 
Dev Dives: Streamline document processing with UiPath Studio Web
Dev Dives: Streamline document processing with UiPath Studio WebDev Dives: Streamline document processing with UiPath Studio Web
Dev Dives: Streamline document processing with UiPath Studio WebUiPathCommunity
 
A Deep Dive on Passkeys: FIDO Paris Seminar.pptx
A Deep Dive on Passkeys: FIDO Paris Seminar.pptxA Deep Dive on Passkeys: FIDO Paris Seminar.pptx
A Deep Dive on Passkeys: FIDO Paris Seminar.pptxLoriGlavin3
 
"ML in Production",Oleksandr Bagan
"ML in Production",Oleksandr Bagan"ML in Production",Oleksandr Bagan
"ML in Production",Oleksandr BaganFwdays
 
Scanning the Internet for External Cloud Exposures via SSL Certs
Scanning the Internet for External Cloud Exposures via SSL CertsScanning the Internet for External Cloud Exposures via SSL Certs
Scanning the Internet for External Cloud Exposures via SSL CertsRizwan Syed
 
Ensuring Technical Readiness For Copilot in Microsoft 365
Ensuring Technical Readiness For Copilot in Microsoft 365Ensuring Technical Readiness For Copilot in Microsoft 365
Ensuring Technical Readiness For Copilot in Microsoft 3652toLead Limited
 
Gen AI in Business - Global Trends Report 2024.pdf
Gen AI in Business - Global Trends Report 2024.pdfGen AI in Business - Global Trends Report 2024.pdf
Gen AI in Business - Global Trends Report 2024.pdfAddepto
 
"Subclassing and Composition – A Pythonic Tour of Trade-Offs", Hynek Schlawack
"Subclassing and Composition – A Pythonic Tour of Trade-Offs", Hynek Schlawack"Subclassing and Composition – A Pythonic Tour of Trade-Offs", Hynek Schlawack
"Subclassing and Composition – A Pythonic Tour of Trade-Offs", Hynek SchlawackFwdays
 
WordPress Websites for Engineers: Elevate Your Brand
WordPress Websites for Engineers: Elevate Your BrandWordPress Websites for Engineers: Elevate Your Brand
WordPress Websites for Engineers: Elevate Your Brandgvaughan
 
Nell’iperspazio con Rocket: il Framework Web di Rust!
Nell’iperspazio con Rocket: il Framework Web di Rust!Nell’iperspazio con Rocket: il Framework Web di Rust!
Nell’iperspazio con Rocket: il Framework Web di Rust!Commit University
 
Tampa BSides - Chef's Tour of Microsoft Security Adoption Framework (SAF)
Tampa BSides - Chef's Tour of Microsoft Security Adoption Framework (SAF)Tampa BSides - Chef's Tour of Microsoft Security Adoption Framework (SAF)
Tampa BSides - Chef's Tour of Microsoft Security Adoption Framework (SAF)Mark Simos
 
The Fit for Passkeys for Employee and Consumer Sign-ins: FIDO Paris Seminar.pptx
The Fit for Passkeys for Employee and Consumer Sign-ins: FIDO Paris Seminar.pptxThe Fit for Passkeys for Employee and Consumer Sign-ins: FIDO Paris Seminar.pptx
The Fit for Passkeys for Employee and Consumer Sign-ins: FIDO Paris Seminar.pptxLoriGlavin3
 
TeamStation AI System Report LATAM IT Salaries 2024
TeamStation AI System Report LATAM IT Salaries 2024TeamStation AI System Report LATAM IT Salaries 2024
TeamStation AI System Report LATAM IT Salaries 2024Lonnie McRorey
 
Passkey Providers and Enabling Portability: FIDO Paris Seminar.pptx
Passkey Providers and Enabling Portability: FIDO Paris Seminar.pptxPasskey Providers and Enabling Portability: FIDO Paris Seminar.pptx
Passkey Providers and Enabling Portability: FIDO Paris Seminar.pptxLoriGlavin3
 
From Family Reminiscence to Scholarly Archive .
From Family Reminiscence to Scholarly Archive .From Family Reminiscence to Scholarly Archive .
From Family Reminiscence to Scholarly Archive .Alan Dix
 
The Role of FIDO in a Cyber Secure Netherlands: FIDO Paris Seminar.pptx
The Role of FIDO in a Cyber Secure Netherlands: FIDO Paris Seminar.pptxThe Role of FIDO in a Cyber Secure Netherlands: FIDO Paris Seminar.pptx
The Role of FIDO in a Cyber Secure Netherlands: FIDO Paris Seminar.pptxLoriGlavin3
 
How to write a Business Continuity Plan
How to write a Business Continuity PlanHow to write a Business Continuity Plan
How to write a Business Continuity PlanDatabarracks
 

Último (20)

SIP trunking in Janus @ Kamailio World 2024
SIP trunking in Janus @ Kamailio World 2024SIP trunking in Janus @ Kamailio World 2024
SIP trunking in Janus @ Kamailio World 2024
 
"Debugging python applications inside k8s environment", Andrii Soldatenko
"Debugging python applications inside k8s environment", Andrii Soldatenko"Debugging python applications inside k8s environment", Andrii Soldatenko
"Debugging python applications inside k8s environment", Andrii Soldatenko
 
Streamlining Python Development: A Guide to a Modern Project Setup
Streamlining Python Development: A Guide to a Modern Project SetupStreamlining Python Development: A Guide to a Modern Project Setup
Streamlining Python Development: A Guide to a Modern Project Setup
 
DevoxxFR 2024 Reproducible Builds with Apache Maven
DevoxxFR 2024 Reproducible Builds with Apache MavenDevoxxFR 2024 Reproducible Builds with Apache Maven
DevoxxFR 2024 Reproducible Builds with Apache Maven
 
Dev Dives: Streamline document processing with UiPath Studio Web
Dev Dives: Streamline document processing with UiPath Studio WebDev Dives: Streamline document processing with UiPath Studio Web
Dev Dives: Streamline document processing with UiPath Studio Web
 
A Deep Dive on Passkeys: FIDO Paris Seminar.pptx
A Deep Dive on Passkeys: FIDO Paris Seminar.pptxA Deep Dive on Passkeys: FIDO Paris Seminar.pptx
A Deep Dive on Passkeys: FIDO Paris Seminar.pptx
 
"ML in Production",Oleksandr Bagan
"ML in Production",Oleksandr Bagan"ML in Production",Oleksandr Bagan
"ML in Production",Oleksandr Bagan
 
Scanning the Internet for External Cloud Exposures via SSL Certs
Scanning the Internet for External Cloud Exposures via SSL CertsScanning the Internet for External Cloud Exposures via SSL Certs
Scanning the Internet for External Cloud Exposures via SSL Certs
 
Ensuring Technical Readiness For Copilot in Microsoft 365
Ensuring Technical Readiness For Copilot in Microsoft 365Ensuring Technical Readiness For Copilot in Microsoft 365
Ensuring Technical Readiness For Copilot in Microsoft 365
 
Gen AI in Business - Global Trends Report 2024.pdf
Gen AI in Business - Global Trends Report 2024.pdfGen AI in Business - Global Trends Report 2024.pdf
Gen AI in Business - Global Trends Report 2024.pdf
 
"Subclassing and Composition – A Pythonic Tour of Trade-Offs", Hynek Schlawack
"Subclassing and Composition – A Pythonic Tour of Trade-Offs", Hynek Schlawack"Subclassing and Composition – A Pythonic Tour of Trade-Offs", Hynek Schlawack
"Subclassing and Composition – A Pythonic Tour of Trade-Offs", Hynek Schlawack
 
WordPress Websites for Engineers: Elevate Your Brand
WordPress Websites for Engineers: Elevate Your BrandWordPress Websites for Engineers: Elevate Your Brand
WordPress Websites for Engineers: Elevate Your Brand
 
Nell’iperspazio con Rocket: il Framework Web di Rust!
Nell’iperspazio con Rocket: il Framework Web di Rust!Nell’iperspazio con Rocket: il Framework Web di Rust!
Nell’iperspazio con Rocket: il Framework Web di Rust!
 
Tampa BSides - Chef's Tour of Microsoft Security Adoption Framework (SAF)
Tampa BSides - Chef's Tour of Microsoft Security Adoption Framework (SAF)Tampa BSides - Chef's Tour of Microsoft Security Adoption Framework (SAF)
Tampa BSides - Chef's Tour of Microsoft Security Adoption Framework (SAF)
 
The Fit for Passkeys for Employee and Consumer Sign-ins: FIDO Paris Seminar.pptx
The Fit for Passkeys for Employee and Consumer Sign-ins: FIDO Paris Seminar.pptxThe Fit for Passkeys for Employee and Consumer Sign-ins: FIDO Paris Seminar.pptx
The Fit for Passkeys for Employee and Consumer Sign-ins: FIDO Paris Seminar.pptx
 
TeamStation AI System Report LATAM IT Salaries 2024
TeamStation AI System Report LATAM IT Salaries 2024TeamStation AI System Report LATAM IT Salaries 2024
TeamStation AI System Report LATAM IT Salaries 2024
 
Passkey Providers and Enabling Portability: FIDO Paris Seminar.pptx
Passkey Providers and Enabling Portability: FIDO Paris Seminar.pptxPasskey Providers and Enabling Portability: FIDO Paris Seminar.pptx
Passkey Providers and Enabling Portability: FIDO Paris Seminar.pptx
 
From Family Reminiscence to Scholarly Archive .
From Family Reminiscence to Scholarly Archive .From Family Reminiscence to Scholarly Archive .
From Family Reminiscence to Scholarly Archive .
 
The Role of FIDO in a Cyber Secure Netherlands: FIDO Paris Seminar.pptx
The Role of FIDO in a Cyber Secure Netherlands: FIDO Paris Seminar.pptxThe Role of FIDO in a Cyber Secure Netherlands: FIDO Paris Seminar.pptx
The Role of FIDO in a Cyber Secure Netherlands: FIDO Paris Seminar.pptx
 
How to write a Business Continuity Plan
How to write a Business Continuity PlanHow to write a Business Continuity Plan
How to write a Business Continuity Plan
 

Introduction To Drug Discovery

  • 1. HERBAL AND DRUG DESIGN TECHNOLOGY Selma Siyavudeen
  • 2.
  • 3.
  • 4. Drug discovery / design - steps IDENTIFICATION OPTIMISATION DEVELOPMENT FINDING A LEAD COMPOUND / NCE QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS, ASSAYS – in vitro and in vivo PHARMACOKINETIC STUDIES TOXICOLOGY TESTING FORMULATION DEVELOPMENT CLINICAL TRIALS REGULATORY APPROVAL LEAD
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15.
  • 16.
  • 17.
  • 18.
  • 19.
  • 20.
  • 22.
  • 23.
  • 24.
  • 25.  
  • 26. Advances in genomics & Microarray Technology Drug development Tracking disease progression Disease risk assessment Genotyping Drug development Drug response Tracking disease progression Therapy development Drug mechanism of action Applications Detect mutations/polymorphisms Analysis of gene expression levels Breif description Mutation/polymorphism analysis Expression analysis Microarray type
  • 27.
  • 28. Historical perspective anticancer Vinca rosea vincristine anticancer Vinca rosea vincaleukoblastine Hypotensive,tranquilizer rauwolfia reserpine foxflove digitoxin cocaine cinchona quinine opium morphine
  • 29.
  • 30.
  • 31. Recent discoveries Galanthus Woronowii Losinsk . Alzheimer”s disease Galanthamine Artemesia annua L. Antimalarial drug Arteether Taxus brevifolia Nutt. Camptotheca acuminata Decne. Catharanthus roseus G.Don plant Anticancer agents properties Paclitaxel Camptothecin Vinflunine Drug
  • 32. Papaver somniferum L. Pain medication Morphine 6-gluconoride Calophyllum lanigerum var. austrocoriaceum Atropa belladona L. Anti HIV drugs antiretroviral and anti mycobacterial agent , n on-nucleoside reverse transcriptase inhibitor of type 1 HIV Effective against AZT resistant strains of HIV Chronic obstructive pulmonary disease inhaled bronchodialator Calanolide A Tiotropium
  • 33. NCE s from India Coleus forskohlii Briq. Dysoxylum binectariferum Hook. Potent adenylate cyclase activator Semisynthetic derivative is approved for treatment of glaucoma tyrosine kinase activity and potent growth inhibitory activity against breast and lung carcinoma cell lines. Forskolin Flavopiridol
  • 34. Commiphora mukul (Stocks)Engl. Lowers serum LDL and triglyceride levels highly efficacious antagonist of FXR (farnesoid X receptor) Guggulsterone, [4,17,(20)-pregnadiene-3,16-dione]
  • 35.
  • 36.
  • 37. DNA Microarray - applications
  • 38. Microarray-based gene expression analysis of multi-component mixtures.
  • 39.
  • 40.
  • 41.
  • 42.