Von willebrands disease

Von Willebrand Disease Douglas Montgomery MD 7/10/2008

What is VWD ,[object Object],[object Object],[object Object]

How does VWF promote clotting ,[object Object],[object Object]

How does VWF promote clotting ,[object Object],[object Object],[object Object]

Inherited VWD is classified into Three types ,[object Object],[object Object]

Type II has 4 subtypes ,[object Object],[object Object],[object Object],[object Object]

Pathophysiology and Clinical Presentation ,[object Object],[object Object],[object Object],[object Object]

Delayed, severe Immediate, mild Bleeding after surgery Common Rare Hemarthroses, muscle hematomas Large, palpable Small, superficial Ecchymoses Absent Present Petechiae Not usually Yes Bleeding after minor cuts Deep in soft tissues (joints, muscles) Skin, mucous membranes (gingivae, nares, GI and genitourinary tracts) Site of bleeding Clotting factor deficiency Platelet defect Clinical characteristic

Clinical Presentation for Type III and Type IIN ,[object Object],[object Object]

Clinical Presentation / Diagnosis ,[object Object],[object Object],[object Object],[object Object]

Difficult Diagnosis And Difficult to Asses Response to treatment ,[object Object],[object Object],[object Object]

Some Lab test for VWF ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

What do the test Measure ,[object Object],[object Object],[object Object],[object Object]

Variables that influence TREATMENT ,[object Object],[object Object],[object Object],[object Object]

6 medical treatments ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

TRIAL OF DDAVP ,[object Object],[object Object],[object Object]

dDAVP ,[object Object],[object Object],[object Object],[object Object]

Nasal Spray dDAVP ,[object Object],[object Object]

VWF replacement therapy for dDAVP REFRACTORY PATIENTS ,[object Object],[object Object],[object Object],[object Object],[object Object]

Unresponsive Refractory Bleeding ,[object Object],[object Object]

Other Tricks ,[object Object],[object Object],[object Object]

Summary OB Management ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

HAPPY TO CONSULT ,[object Object],[object Object],[object Object],[object Object],[object Object]

Von willebrands disease

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