2. Dependent to Vitamin D Rachitisme Type II
Resistance to Anderogens:
Complete testicular feminization (Recessive X-linked)
Incomplete testicular feminization (Recessive X-linked)
5-α- Reductase deficiency (Recessive Autosomal)
Infertility in men (Recessive X-linked)
Male Pseudohermaphroditism (Recessive X-linked)
3. Cystic fibrosis:
Unusual response to α-Adrenergics,
β-Adrenergics and Cholinergics
Down syndrome:
More sensitive to Atropine and β-Adrenergics
Riley-Day syndrome:
More sensitive to Norepinephrine
10. Pharmacoethnic differences
Deceased activity in Indians and Eastern people
Disulfiram like reaction
12. Hepatic and Erythropoietic
Congenital and Acquired
Neurologic disorders and Photosensitivity
Increased δ-amino levulinic acid synthase activity
and Heme biosynthesis
Erythropoeitic protoporphyria: Ferrochelatase
deficiency
Congenital Erythropoeitic porphyria:
Uroporphyrinogen III cosynthase deficiency
Acute intermittent porphyria: decreased
Porphobilinogen deaminase
Hexachlorobenzene and TCDD
13. Increased Aryl hydrocarbon hydroxylase P450
Production of toxic, motagen, teratogen and
carcinogen products
P1 450 and P3 450
Relationship between AHH induction and
bronchogenic carcinoma risk in smokers
Relationship between low AHH induction and
Leukemia and Aplastic anemia
14. Relationship between Pharmacologic disorders
and cancer:
Low Isoniaside Acetylator labor in chemical
colors companies: Increased risk of bladder
cancer
High Debrisoquine metabolizers: Increased risk
of hepatic and alimentary cancer and lung
cancer in smokers
High AHH inducers: Increased risk of
bronchogenic carcinoma in smokers
16. Albumin , Pre albumin and TBG
Increased TBG capacity: Dominant Autosomal
Decreased TBG capacity: X-linked
17. Primary idiopathic hemochromatosis:
Two fold increase in Ferrum and occupation
Not change in total Transferrin and tendency
Hereditory hemochromatosis:
Recessive Autosomal
18. Hepatolenticular degeneration
Decreased Ceruloplasmin
Normal amount of Tyrosinase and
Erythrocuprein
Treatement with Penicillamine
20. 5 % of American people
Recessive Autosomal
Ocular products
21. Hypermetabolic state of skeletal muscles
Tachycardia, Arrhythmia, Hyperpyrexia and
Rigidity
Idiopathic increased of sarcoplasm Ca
Three fold increased O2 consumption during
general anesthesia
Inhalation halogens and Succinylcholine
Muscle sample diagnostic test (in-vitro),
sensitivity to Caffeine and Halothane
Recessive Autosomal
22. Dose dependent and rarely dose independent
Anaerobically reduction by P450 II
Last oxidative metabolite is a suicide substrate
and make a covalent bound to P450.
23. Dose dependent and reversible
Dose independent:
Aplasia, A Pharmacogenetic disorder
Oxamyl chloride, covalent binding
24. Gingiva hyperplasia due to Phenytoin
More thromboembolic disorders in A, B and
AB blood groups
26. Effects of genetic differences on acute response
to drugs
Effects of genetic differences on chronic
response to drugs
Natural selection of different genes by
environmental changes
28. Relationship between cancer and acetylation
differences
Relationship between cancer and Lupus
erythematosus and Hemolytic anemia
Relationship between Debrisoquine and Ah
locus
Relationship between neurotoxicity and
acetylation differences
Labor sensitivity
29. Ethnopharmacology
The reason of quantitative differences in drugs
metabolism between different population
Sickle shape anemia:
Hemoglobin S heterozygotes are resistant to
malaria