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Alfonso Valle MuñozENTRUST-AF-PCI
Vranckx P, Valgimigli M, Eckardt L, et al. Lancet. Online first. DOI:https://doi.org/10.1016/S0140-6736(19)31872-0
Alfonso Valle MuñozENTRUST-AF-PCI
AUGUSTUS
ACS/PCI4
(apixaban)
ENTRUST-
AF-PCI5
(edoxabán)
2013
PIONEER
AF-PCI2
(rivaroxaban)
2016
RE-DUAL PCI3
(dabigatrán)
2017 2019
• 1. Dewilde et al. Lancet 2013; 2. Gibson et al. N Engl J Med 2016; 3. Cannon et al. N Engl J Med 2017; 4. Lopes et al N- Engl J Med 2019; 5. ClinicalTrials.gov: NCT02866175
Alfonso Valle MuñozENTRUST-AF-PCI
Vranckx P, Valgimigli M, Eckardt L, et al. Lancet. Online first. DOI:https://doi.org/10.1016/S0140-6736(19)31872-0
- EDOXABAN + P2Y12 vs
- VKA+P2Y12+AAS 12meses
- FA y SCA
- FA y Síndrome coronario crónico con ICP+stent
- Sangrado mayor ISTH
- Sangrado clínicamente relevante no mayor (ISTH)
Alfonso Valle MuñozENTRUST-AF-PCI
Vranckx P, Valgimigli M, Eckardt L, et al. Lancet. Online first. DOI:https://doi.org/10.1016/S0140-6736(19)31872-0
- EDOXABAN + P2Y12 vs
- VKA+P2Y12+AAS 12meses
- FA y SCA
- FA y Síndrome coronario crónico con ICP+stent
- Eficacia:
Exploratorio
Alfonso Valle MuñozENTRUST-AF-PCI
Vranckx P, Valgimigli M, Eckardt L, et al. Lancet. Online first. DOI:https://doi.org/10.1016/S0140-6736(19)31872-0
Alfonso Valle MuñozENTRUST-AF-PCI
Vranckx P, Valgimigli M, Eckardt L, et al. Lancet. Online first. DOI:https://doi.org/10.1016/S0140-6736(19)31872-0
Alfonso Valle MuñozENTRUST-AF-PCI
Vranckx P, Valgimigli M, Eckardt L, et al. Lancet. Online first. DOI:https://doi.org/10.1016/S0140-6736(19)31872-0
Alfonso Valle MuñozENTRUST-AF-PCI
Vranckx P, Valgimigli M, Eckardt L, et al. Lancet. Online first. DOI:https://doi.org/10.1016/S0140-6736(19)31872-0
Alfonso Valle MuñozENTRUST-AF-PCI
Vranckx P, Valgimigli M, Eckardt L, et al. Lancet. Online first. DOI:https://doi.org/10.1016/S0140-6736(19)31872-0
Alfonso Valle MuñozENTRUST-AF-PCI
Vranckx P, Valgimigli M, Eckardt L, et al. Lancet. Online first. DOI:https://doi.org/10.1016/S0140-6736(19)31872-0
Alfonso Valle MuñozENTRUST-AF-PCI
ENTRUST-AF PCI en pacientes con FA y ICP:
• Edoxaban 60 + P2Y12 es no inferior a triple terapia en sangrado
mayor o clínicamente relevante a 12 meses
• La doble terapia con Edoxaban muestra unas tasas de eventos
isquémicos similar a la triple terapia
• En paciente con FA e ICP la terapia dual con edoxaban es NO inferior
en sangrados vs AVK en triple terapia, sin diferencias en eventos
isquémicos

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