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PURE Study

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La Dra. Silvia Valbuena López analiza los resultados del estudio presentado en ESC Congress 2019.

Publicado en: Salud y medicina
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PURE Study

  1. 1. Silvia Valbuena LópezPURE Study PURE – Contrasting patterns of CV disease, cancer and related mortality between high- versus low-middle income countries in 21 countries PURE - Impact of modifiable risk factors on CV disease and mortality Lancet. https://doi.org/10.1016/S0140-6736(19)32008-2 Lancet. https://doi.org/10.1016/S0140-6736(19)32008-2 On behalf of the Prospective Urban Rural Epidemiology (PURE) Study investigators
  2. 2. Silvia Valbuena LópezPURE Study PURE Study Total of 202000 from 27 countries: ongoing follow-up Now included 167000 from 21 countries with follow-up data (4 HIC, 12 MIC, 5 LIC) Adults: 35-70 years Follow-up 9.5 years
  3. 3. Silvia Valbuena LópezPURE Study AIM 1. To describe the incidence of various diseases and related deaths in countries at different economic levels (high, middle and low income countries, HIC, MIC and LIC) 1. To document relative importance of risk factors for CVD and mortality overall and in HIC, MIC and LIC
  4. 4. Silvia Valbuena LópezPURE Study BASELINE CHARACTERISTICS
  5. 5. Silvia Valbuena LópezPURE Study CAUSE OF DEATH. OVERALL
  6. 6. Silvia Valbuena LópezPURE Study CAUSE OF DEATH BY COUNTRY INCOME LEVEL
  7. 7. Silvia Valbuena LópezPURE Study IMPACT OF MODIFIABLE RISK FACTORS ON CVD AND MORTALITY OBJECTIVE • Quantify risk for CVD and death associated with 14 common, modifiable risk factors • Document the variations in the importance of risk factors by HIC, MIC and LIC
  8. 8. Silvia Valbuena LópezPURE Study METHODS • N 152722 individuals without CVD • Risk factors - Behavioural  tobacco, diet, alcohol, physical activity and salt intake - Metabolic  HTN, DM, obesity and lipids - Psychosocial  education, depression - Grip strengh - Air pollution  household (solid fuel use) and ambient air pollution
  9. 9. Silvia Valbuena LópezPURE Study POPULATION ATRIBUTABLE FRACTION CVD Mortality
  10. 10. Silvia Valbuena LópezPURE Study POPULATION ATRIBUTABLE FRACTION. CVD
  11. 11. Silvia Valbuena LópezPURE Study POPULATION ATRIBUTABLE FRACTION. MORTALITY
  12. 12. Silvia Valbuena LópezPURE Study • CVD is the most common cause of death globally (40%) and in LIC • Cancer deaths more frequent in many HIC • Modifiable risk factors explain around 70% of the risk of CVD and death • Hypertension is by large the most relevant risk factor for CVD • Importance of air pollution, grip strength and education previously underappreciated IN SUMMARY
  13. 13. Silvia Valbuena LópezPURE Study CONCLUSIONS Reduction in CVD and mortality requires • Modifying risk factors with larger effects, with emphasis on low cost proven interventions • Improving healthcare, education and reducing indoor and outdoor air pollution, specially in poorer countries

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