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Semantic Web Technologies as a Framework for Clinical Informatics Chimezie Ogbuji (CCF) Chris Pierce (CCF) Chris Deaton (Cycorp) Semantic Technology Conference 16 June 2009
Me ,[object Object],[object Object],[object Object],[object Object]
Outline ,[object Object],[object Object],[object Object],[object Object],[object Object]
What is Informatics? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Bioinformatics ,[object Object],[object Object]
Medical Informatics ,[object Object],[object Object]
Cohort Studies ,[object Object],[object Object],[object Object],[object Object]
Retrospective Cohort Studies ,[object Object],[object Object],[object Object],[object Object]
Reasoning Methods in Biomedical Informatics
Areas of Applied Ontology ,[object Object],[object Object],[object Object],[object Object]
Challenges in  Traditional C ohort Identification ,[object Object],[object Object],[object Object],[object Object]
Patient Records ,[object Object],[object Object]
Patient Records Cont. ,[object Object],[object Object]
RDF Datasets ,[object Object]
RDF Datasets Cont. ,[object Object],[object Object]
SPARQL &Cohort Identification ,[object Object],[object Object],[object Object],[object Object]
Use of Named Graphs ,[object Object],[object Object],[object Object]
Use of Named Graphs Cont. ,[object Object],[object Object]
 
Patient Record Ontology ,[object Object],[object Object],[object Object],[object Object]
Ontology: Diagnoses
Ontology: Coronary Anatomy
Ontology: Pathogens
Ontologies: Family History
Integration with Cyc KB ,[object Object],[object Object],[object Object]
Semantic Research Assistant ,[object Object],[object Object],[object Object],[object Object]
“ Semantic Interface” ,[object Object],[object Object],[object Object]
Screenshots
 
 
 
 
 
 
 
 
CycL Query (thereExists ?ID (thereExists ?PATIENT (and (cCFhasLeftAtriumDiameter ?CATH-OR-ECHO ?DISTANCE) (patientTreated ?CATH-OR-ECHO ?PATIENT) (cCFCCFID ?PATIENT ?ID) (isa ?CATH-OR-ECHO Echocardiogram) (patientTreated ?CATH-OR-ECHO ?PATIENT) (or (and (patientSex ?PATIENT MaleHuman) (greaterThan ?DISTANCE ( (Centi Meter) 4.2))) (and (patientSex ?PATIENT FemaleHuman) (greaterThan ?DISTANCE ( (Centi Meter) 3.8)))) (temporallyBetween-Inclusive ?CATH-OR-ECHO (MonthFn January (YearFn 2008)) (DayFn 15 (MonthFn March (YearFn 2008)))))))
SPARQL Queries SELECT ?VAR0 ?VAR1 ?VAR2 ?VAR3 ?VAR4 ?VAR5 ?VAR6 WHERE { ?VAR0 ptrec:hasSex ptrec:Sex_female . ?VAR0 a ptrec:Patient . ?VAR1 dnode:contains ?VAR0 . ?VAR1 a ptrec:PatientRecord . ?VAR1 dnode:contains ?VAR2 . ?VAR2 a ptrec:Event_evaluation_echocardiogram> . ?VAR2 ptrec:hasLeftAtriumDiameter ?VAR3 . FILTER (?VAR3 > xsd:float(3.8)) ?VAR2 dnode:contains ?VAR4 . ?VAR4 a ptrec:EventStartDate . ?VAR4 ptrec:hasDateTimeMax ?VAR5 . FILTER (?VAR5 > xsd:dateTime("2007-12-31T23:59:59")) FILTER (xsd:dateTime("2008-03-16T00:00:00") > ?VAR5) ?VAR0 ptrec:hasCCFID ?VAR6 . }
 
Challenges ,[object Object],[object Object],[object Object],[object Object]
Challenges Cont. ,[object Object],[object Object],[object Object],[object Object]
Questions? ,[object Object],[object Object],[object Object]

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Semantic Web Technologies as a Framework for Clinical Informatics

  • 1. Semantic Web Technologies as a Framework for Clinical Informatics Chimezie Ogbuji (CCF) Chris Pierce (CCF) Chris Deaton (Cycorp) Semantic Technology Conference 16 June 2009
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  • 9. Reasoning Methods in Biomedical Informatics
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  • 37. CycL Query (thereExists ?ID (thereExists ?PATIENT (and (cCFhasLeftAtriumDiameter ?CATH-OR-ECHO ?DISTANCE) (patientTreated ?CATH-OR-ECHO ?PATIENT) (cCFCCFID ?PATIENT ?ID) (isa ?CATH-OR-ECHO Echocardiogram) (patientTreated ?CATH-OR-ECHO ?PATIENT) (or (and (patientSex ?PATIENT MaleHuman) (greaterThan ?DISTANCE ( (Centi Meter) 4.2))) (and (patientSex ?PATIENT FemaleHuman) (greaterThan ?DISTANCE ( (Centi Meter) 3.8)))) (temporallyBetween-Inclusive ?CATH-OR-ECHO (MonthFn January (YearFn 2008)) (DayFn 15 (MonthFn March (YearFn 2008)))))))
  • 38. SPARQL Queries SELECT ?VAR0 ?VAR1 ?VAR2 ?VAR3 ?VAR4 ?VAR5 ?VAR6 WHERE { ?VAR0 ptrec:hasSex ptrec:Sex_female . ?VAR0 a ptrec:Patient . ?VAR1 dnode:contains ?VAR0 . ?VAR1 a ptrec:PatientRecord . ?VAR1 dnode:contains ?VAR2 . ?VAR2 a ptrec:Event_evaluation_echocardiogram> . ?VAR2 ptrec:hasLeftAtriumDiameter ?VAR3 . FILTER (?VAR3 > xsd:float(3.8)) ?VAR2 dnode:contains ?VAR4 . ?VAR4 a ptrec:EventStartDate . ?VAR4 ptrec:hasDateTimeMax ?VAR5 . FILTER (?VAR5 > xsd:dateTime("2007-12-31T23:59:59")) FILTER (xsd:dateTime("2008-03-16T00:00:00") > ?VAR5) ?VAR0 ptrec:hasCCFID ?VAR6 . }
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Notas del editor

  1. This is a usecase exploring the use of SW technologies for managing and identifying patient populations
  2. CWRU research is regarding efficient RDF querying and applications of clinical ontologies
  3. Drag & Drop “DISTANCE” onto QUANTITY to connect the meaurement to the Left Atrium Diameter. Do the same for both, male & female.
  4. Click on the blue ball in the upper left hand corner of each box containing the male & female data and drag them into the Group Box
  5. Right click on the blue ball in the upper left-hand corner of the Group Box and change group type to “Either of the following is true.”