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Common genetic association in autoimmune diseases

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Chris Cotsapas
Chris Cotsapas
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Converging on a theme: autoimmune genetic architecture across diseases Chris Cotsapas PhD Daly Lab MGH/Broad Institute [email_address] broad.mit.edu/~cotsapas/autoimm.html
Acknowledgements Mark Daly Steve Rich David Hafler Sarah Krause John Todd Jeff Barrett Tim Behrens Rob Graham John Harley Carl Langefeld Pat Gaffney Kathy Moser JT Elder Goncalo Abecasis Peter Gregersen Lars Klareskog Leonid Padyukov Robert Plenge David van Heel Judy Cho Michel Georges John Rioux Chris Amos
Familial aggregation of autoimmunity ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Autoimmune associations
Genes common to >1 disease
Motivations ,[object Object],[object Object],[object Object],[object Object]
Auto-immune GWAS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
FOCiS/NOC meta-analysis
Locus selection ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Data collection ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Loci ascertained in T1D: Association in RA
 
Next steps ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Overlap between diseases

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