This document summarizes hypertension and hypertensive disorders in pregnancy. It discusses normal hemodynamic changes in pregnancy, classification and treatment of hypertension, preeclampsia and eclampsia. Conditions like acute fatty liver of pregnancy, thrombotic thrombocytopenic purpura-hemolytic uremic syndrome and systemic lupus erythematosus flares are also mentioned as they can present similarly to preeclampsia/eclampsia. First line antihypertensive agents during pregnancy include methyldopa, labetalol and nifedipine. Delivery is the only cure for preeclampsia.

1. Hypertension in Pregnancy and Women of Childbearing Age American Journal of Medicine 2009

8. Rx of essential HTN in women of childbearing age Part 1

11. FDA pregnancy drug categories A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester. C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans , but potential benefits may warrant use of the drug in pregnant women despite potential risks. D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks. X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.

16. Normal hemodynamic changes in Pregnancy Part 2

20. Approach to HTN during pregnancy Part 3

31. HTN drugs for use during pregnancy Apresolin 0.5 amp IM PRN Q20~30min if SBP>170mmHg or DBP>110mmHg Trandate Adalat Aprezin Apresolin Hydrochlorothiazide

32. Hypertensive disorders of pregnancy Part 4

52. Rx of HTN during breastfeeding Part 5

54. Drugs often prescribed during lactation

55. Take Home Messages