ICAWC 2014 Istanbul - Cagri Akkin's presentation on Canine Parvovirus covers diagnosis, treatment, protection and vaccination.

2. WHAT IS CPV?
Çağrı AKKIN DVM
vet_cagriakkin@hotmail.com +90542 202 37 10

3. CONTENTS
CANINE PARVOVIRAL ENTERITIS
Vomiting
Diarrhea
Severe dehydration
Endotoxic or septic shock
Multiple organ failure
Without treatment
WHICH BREEDS ARE UNDER RISK
ETIOLOGY
HOW CPV INFECTS A DOG
PATHOPHYSIOLOGY
CLINICAL FINDINGS
DIAGNOSIS
TREATMENT
Fluid Therapy
Systemic Antibiotics
Anti-Emetics
Aggressive Adjunctive Treatments
Eradication of Intestinal Parasites
PREVENTION AND CONTROL

4. WHAT IS CPV?
CANINE PARVOVIRAL ENTERITIS
Vomiting

5. WHAT IS CPV?
CANINE PARVOVIRAL ENTERITIS
Diarrhea

6. WHAT IS CPV?
CANINE PARVOVIRAL ENTERITIS
Severe dehydration

7. WHAT IS CPV?
CANINE PARVOVIRAL ENTERITIS
Endotoxic or septic shock

8. WHAT IS CPV?
CANINE PARVOVIRAL ENTERITIS
Multiple organ failure

9. WHAT IS CPV?
CANINE PARVOVIRAL ENTERITIS
Without treatment

10. Which breeds are under risk

11. Etiology
DNA
1970
CPV-2b

12. HOW CPV INFECTS A DOG

13. HOW CPV INFECTS A DOG

14. HOW CPV INFECTS A DOG

15. Pathophysiology

16. Pathophysiology
Infection in utero or in pups <8wk old or born
to unvaccinated dams

17. 4–5 days later

19. Clinical Findings
Physical examination findings can include depression,
fever, dehydration, and intestinal loops that are dilated
and fluid filled. Abdominal pain warrants further
investigation to rule out the potential complication of
intussusception. Severely affected animals may present
collapsed with prolonged capillary refill time, poor pulse
quality, tachycardia, and hypothermia—signs potentially
consistent with septic shock. Although CPV-associated
leukoencephalomalacia has been reported, CNS signs
are more commonly attributable to hypoglycemia, sepsis,
or acid-base and electrolyte abnormalities. Inapparent or
subclinical infection is common.

20. Diagnosis
Clinical signs
Leukopenia, lymphopenia
ELISA PCR Rapid test kits

21. Treatment
Fluid Therapy

22. Treatment
Systemic Antibiotics

23. Treatment
Anti-Emetics

24. Treatment
Aggressive Adjunctive Treatments
A polyvalent equine origin antiserum against LPS
endotoxin
Antiserum
Convalescent serum
Recombinant granulocyte colony stimulating factor (rG-CSF)
Oseltamivir

25. Treatment
Eradication of Intestinal Parasites

26. Treatment
Nutrition
PPN
A liquid diet

27. Prevention and Control
Vaccination for puppies
6–8, 10–12, and 14–16 wk

28. Prevention and Control
Vaccination for adults
Once a year

29. Prevention and Control
Isolation housing
Gowning and gloving of personnel
Frequent and thorough cleaning

30. Prevention and Control
1:30

31. BIBLIOGRAPHY
Openi.nlm.nih.gov
Histology-world.com
dvm360.com
The Merck Veterinary Manual
8th edition

32. Thank you for listening!
Any questions?
Learn from yesterday, live for today, hope for
tomorrow. The important thing is not to stop
questioning.
A. Einstein