1) Diabetic nephropathy is a kidney disease caused by damage from uncontrolled diabetes, often accompanied by high blood pressure. It involves thickening and scarring of the kidney's filtering units called glomeruli. 2) The trial drug formula, containing herbs like Berberis vulgaris and Solanum nigrum, improved creatinine clearance in 65.71% of patients with mild to moderate renal impairment after 120 days. For patients with severe impairment, a slower response was seen. 3) The formulation acts as a renal function modulator through vasodilation and improved blood flow. It is recommended for early stages of diabetic nephropathy and was found to be an effective and affordable