015.effect of periodontal diseases on outcome of various systemic conditions

1. Dr Jaffar Raza Syed Page 1
Effect of PDD on outcome of various SYSTEMIC Conditions
There is definite association between oral infection and systemic diseases e.g.
--atherosclerosis,
--cardiovascular diseases,
--cerebrovascular diseases,
--premature low-birth infants  Adverse pregnancy outcomes
--pulmonary diseases

2. Dr Jaffar Raza Syed Page 2
Periodontal Disease And Coronary Heart Disease/Atherosclerosis
--correlation between the PD disease and degree of coronary atheromatosus
--periodontal disease is a risk factor for CHD, independent of other classic
risk factors
--other risk factors are smoking, diabetes and low socioeconomic status

3. Dr Jaffar Raza Syed Page 3
Effect Of Periodontal Infection On Ischemic Heart Diseases
--IHD is associated with the process of atherogenesis and thrombogenesis.
--Increased viscosity of blood may promote major ischemic heart disease
and stroke by increasing the thrombus formation
--Increased plasma fibrinogen is a recognized risk factor
--elevated white blood cell count and coagulation factor VIII has
been associated with risk of ischemic heart disease

4. Dr Jaffar Raza Syed Page 4

5. Dr Jaffar Raza Syed Page 5

6. Dr Jaffar Raza Syed
Atherosclerosis
Page 6

7. Dr Jaffar Raza Syed Page 7
Periodontal Disease And Diabetes Mellitus
--Systemic infection increases tissue resistance to insulin,
--preventing glucose from entering target cells causing elevated blood
glucose level and requiring increased pancreatic insulin production
to maintain normoglycemia.
--possible that chronic Gram-negative periodontal infection may also result
in increased insulin resistance and poor glycemic control.

8. Dr Jaffar Raza Syed Page 8
Role Of Periodontitis In Pregnancy Outcome
--role in preterm low birth weight and preeclampsia.
--Periodontopathic organisms  Host cytokines production
--P.g  associated with significant increase in fetal death and a decrease
in fetal birth weight
--significant increase in TNF- α and PGE2 levels
--correlation between TNF- α and PGE2 levels, as well as fetal death and
growth retardation
--women with severe periodontitis are 7.5 times more likely than
women without periodontal disease to have an infant with preterm
low-birth weight.

9. Dr Jaffar Raza Syed Page 9