Se ha denunciado esta presentación.
Se está descargando tu SlideShare. ×

VITAMIN B1 THIAMINE MUHAMMAD MUSTANSAR

Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Próximo SlideShare
vitamin B1
vitamin B1
Cargando en…3
×

Eche un vistazo a continuación

1 de 38 Anuncio
Anuncio

Más Contenido Relacionado

Presentaciones para usted (20)

Similares a VITAMIN B1 THIAMINE MUHAMMAD MUSTANSAR (20)

Anuncio

Más de Dr Muhammad Mustansar (20)

Más reciente (20)

Anuncio

VITAMIN B1 THIAMINE MUHAMMAD MUSTANSAR

  1. 1. 1
  2. 2. • THIAMINE •B1 • By •DR MUSTANSAR
  3. 3. • Thiamine was the first of the water soluble B vitamins to be identified as an essential nutrient. Chemically, it consists of a substituted pyrimidine ring (A) and a thiazole, connected by a methyl group. The term vitamin B1 encompasses several compounds with thiamine-like effects.
  4. 4. • Naturally occurring B1 consists mostly of thiamine phosphates. In pharmaceuticals, water-soluble thiamine derivatives like thiamine hydrochloride or nitrate as well as lipophilic thiamine analogues like benfo-thiamine or fursulthiamine are used.
  5. 5. B1: structure & function
  6. 6. 7 THIAMINE (VIT B1) It is also called Anti Beri-Beri factor, Anti Neuritic factor. It is colorless basic organic compound composed of a sulfated pyramidine ring.
  7. 7. 8 Source • PLANTCEREALS, PEAS, BEANS, NUTS VEGETABLES • ANIMALLIVER, KIDNEY, EGGS, PORK MEAT, MILK
  8. 8. Vitamin B1 (Thiamine) SOURCES  Cereals  Pulses  Oil seeds  Nuts  Yeast  Meat  Fish  Egg  Milk RDA: Adults 1.2-1.5 mg/day
  9. 9. 10 Absorption and excretion It is readily absorbed from both small & large intestine. The capacity of human intestine to absorb this vitamin is limited to about 5mg per day. Any excess supply of thiamine is excreted in the urine.
  10. 10. BIOCHEMICAL FUNCTIONS: THIAMINE • TPP [cocaroxylase] being an essential part of the decarboxylating dehydrogenases acts as a cofactor in many important reactions in carbohydrate metabolism i.e., dehydrogenase [PDH] complex and α-ketoglutarate dehydrogenase [αKGDH] complex i. Oxidative Decarboxylation of α-ketoacids
  11. 11. ii. Conversion of α-Ketoglutarate to succinyl- SCoA iii. TPP acts as coenzyme in reactions catalyzed by transketolase iv. Tryptophan metabolism: Tryptophan pyrrolase Tryptophan N-formylkynurenine O2
  12. 12. v. TPP is a coenzyme for mitochondrial branched chain α-ketoacid dehydrogenases [decarboxylases] which oxidatively decarboxylate α-ketoacids formed in the catabolsim of valine, leucine and isoleucline.
  13. 13. v. In the nervous system: TPP is a cofactor for the synthesis of acetylcholine. vi. TPP also acts as a coenzyme [co- carboxylase] for pyruvate carboxylase in yeast for non-oxidative decaroxylation of pyruvate to acetaldehyde.
  14. 14. THIAMIN IMPORTANCE
  15. 15. 18 Functions Essential for normal growth and development Essential for maintaining nerves in normal condition Nervous tissue – it plays important role in the normal functioning of the entire nervous system. Digestion – it aids in the digestion especially that of carbohydrates.
  16. 16. FUNCTIONS Essential for normal functioning of nerves Co-enzymatic activities- carbohydrate, nucleic acid and energy synthesis
  17. 17. 20 Daily requirement Men – 1.3 mg women – 1.0 mg Pregnancy and lactation 2mg Children – 1.1mg.
  18. 18. DEFICIENCY  Beri beri Earliest symptoms: anorexia dyspepsia heaviness and weakness of legs. calf tenderness
  19. 19. 22 Deficiency Nervous disorders – when cells cannot metabolize glucose, it affects the nervous system first, since it depends entirely on glucose for its energy requirement. & There is mental depression.
  20. 20. Digestive symptoms- it occurs due to defective hydrochloric acid production in the stomach patient complains of loss of appetite, poor digestion, loss of weight.
  21. 21. 24 PROLONGED DEFICIENCY BERI BERI a) DRY BERI BERI b) WET BERI BERI.. c) INFANTILE BERI BERI Other diseases which can be associated with it are wernickes encephalopathy peripheral neuritis korsakoff’s psychosis.
  22. 22. 25 BERI-BERI Early symptoms: Irritability, fatigue, restlessness, decreased appetite. Later symptoms:  tingling numbness in the extremities  dyspnoea  cyanosis  unusual behaviour  seizures  loss of conscious
  23. 23. 26 DRY BERI BERI Clinical features:-  it is peripheral neuropathy.  In long standing cases, there is degeneration and demyelination of both sensory & motor nerve INFANTILE BERI BERI  Vomiting  Weight loss  Convulsions
  24. 24. Wet beri beri Dry Beri beri  Oedema of legs, face Progressive muscle weaknes and trunk and serous cavities. disability  Calf muscles are swollen and tender Neurological manifestations  Palpitation and breathlessness  Low diastolic BP, high systolic.  Fast pulse  Heart becomes weaker and patient dies of heart failure
  25. 25. 28 Wet beri beri It is marked by cardiac dilation with four chamber enlargement, pallor and flabbiness of myocardium. Etiology :- Diet  Alcoholics- interferes with intestinal absorption of thiamine
  26. 26. Infantile Beri beri  Infants born to mother with low thiamine in their breast milk.  Restlessness and sleeplessness  Anorexia, vomiting and breathlessness  cardiac dilatation and failure.  Sudden death if not treated urgently with thiamine.
  27. 27. 30
  28. 28. Wernicke-korsakoff psychosis Seen mostly in chronic alcoholics Body demand of thiamine increases in alcoholism Characterized by: • Dementia • Apathy • Nystagmus
  29. 29. Clinical features  Odema- leg, face. Anorexia Dyspepsia Rapid pulse
  30. 30. 36 Oral manifestation There is hypersensitivity of oral mucosa Pain in tongue, teeth, jaw, and face
  31. 31. 37 Pathogenesis- Deficiency Incomplete metabolism of glucose Accumulation of pyruvic acid & lactic acid in tissue & body fluid Dilation of peripheral blood vessels Fluid may leak out through capillaries, producing edema High cardiac output, heart dilation.
  32. 32. 38 Management Complete rest Thiamine 50mg IM for 3 days then 10mg 3 times daily by oral route.  Infantile beriberi is treated via mothers milk. The mother should receive 10,000mcg twice daily, in addition infant should be given thiamine in doses of 10,000 to 20,000 mcg IM once in a day for 3 days

×