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JSS Medical College, Mysuru
Imaging in Scurvy
-Dr.Shilpa
Resident,
JSS Medical College ,Mysuru
Please visit www.jssmcradiology.com for more Radiology education
For more Radiology Education
visit www.jssmcradiology.com
JSS Medical College, Mysuru
Introduction..
(Barlow’s disease, hypovitaminosis C)
• Pathology:
• Vitamin C necessary for Endothelial lining :
deficiency causes increased vascular fragility
• Decreased osteoblastic activity and cartilage
proliferation resulting in decreased formation of
bony matrix
• Normal mineralisation
• Osteoporosis
JSS Medical College, Mysuru
Radiologic features
1.Dense zone of provisional calcification (white line of
Frankel).
2.Corner (angle) sign-Corner (angle) sign.
Irregularity of the metaphyseal margins frequently
occurs secondary to infarctions of the epiphyseal-
metaphyseal junction.
3. Pelken’s spurs.
4. Scorbutic zone (Trümmerfeld’s zone).
5.Subperiosteal hemorrhage.
JSS Medical College, Mysuru
PA Knee:
Characteristic changes:
1. Generalized osteopenia,
2. Dense zone of provisional calcification,
3. Scorbutic zone,
4. Pelken’s spurs ,
5. Wimberger’s sign (ring epiphyses) and
6. Subperiosteal hemorrhages
JSS Medical College, Mysuru
WHITE LINE OF FRENKEL
• White line in the zone of provisional
calcification at the growing metaphysis
• Dense zone of provisional calcification
(white line of Frankel).
• Cartilage proliferation decreased with
normal mineralisation resulting in
widened and dense zone of provisional
calcification
JSS Medical College, Mysuru
WIMBERGER SIGN
• Epiphysis is small sharply
marginated by sclerotic rim
with central portion more
radiolucent.
• Due to decrease cartilage
proliferation and unimpaired
mineralization (sclerosis)
JSS Medical College, Mysuru
TRUMMERFELD ZONE (SCORBUTIC ZONE)
• Transverse radiolucent band adjacent
to zone of provisonal calcification due
to suppressed osteoblastic activity
with normal mineralisation
• Trabecular bone mass is decreased in
zone of primary and secondary
spongiosa. Scorbutic zone
(Trümmerfeld’s zone).
JSS Medical College, Mysuru
PELKAN’S SPUR
• Zone of provisional calcification extends
beyond the margins of the metaphysis
resulting in periosteal elevation and marginal
spur formation
• These bony protuberances occur at the
metaphyseal margins and extend at right
angles away from the shaft axis.
JSS Medical College, Mysuru
CORNER (ANGLE) SIGN
• Irregularity of the metaphyseal
margins secondary to infractions
of the epiphyseal-metaphyseal
junction
JSS Medical College, Mysuru
SUBPERIOSTEAL HEMORRAGES
• Due to increased capillary
permeability
• Seen in ends of long
bones(femur,tibia, humerus)
• May cause periosteal elevation and
new bone formation
JSS Medical College, Mysuru
Thank You
For more Radiology Education visit
www.jssmcradiology.com

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Imaging in scurvy

  • 1. JSS Medical College, Mysuru Imaging in Scurvy -Dr.Shilpa Resident, JSS Medical College ,Mysuru Please visit www.jssmcradiology.com for more Radiology education For more Radiology Education visit www.jssmcradiology.com
  • 2. JSS Medical College, Mysuru Introduction.. (Barlow’s disease, hypovitaminosis C) • Pathology: • Vitamin C necessary for Endothelial lining : deficiency causes increased vascular fragility • Decreased osteoblastic activity and cartilage proliferation resulting in decreased formation of bony matrix • Normal mineralisation • Osteoporosis
  • 3. JSS Medical College, Mysuru Radiologic features 1.Dense zone of provisional calcification (white line of Frankel). 2.Corner (angle) sign-Corner (angle) sign. Irregularity of the metaphyseal margins frequently occurs secondary to infarctions of the epiphyseal- metaphyseal junction. 3. Pelken’s spurs. 4. Scorbutic zone (Trümmerfeld’s zone). 5.Subperiosteal hemorrhage.
  • 4. JSS Medical College, Mysuru PA Knee: Characteristic changes: 1. Generalized osteopenia, 2. Dense zone of provisional calcification, 3. Scorbutic zone, 4. Pelken’s spurs , 5. Wimberger’s sign (ring epiphyses) and 6. Subperiosteal hemorrhages
  • 5. JSS Medical College, Mysuru WHITE LINE OF FRENKEL • White line in the zone of provisional calcification at the growing metaphysis • Dense zone of provisional calcification (white line of Frankel). • Cartilage proliferation decreased with normal mineralisation resulting in widened and dense zone of provisional calcification
  • 6. JSS Medical College, Mysuru WIMBERGER SIGN • Epiphysis is small sharply marginated by sclerotic rim with central portion more radiolucent. • Due to decrease cartilage proliferation and unimpaired mineralization (sclerosis)
  • 7. JSS Medical College, Mysuru TRUMMERFELD ZONE (SCORBUTIC ZONE) • Transverse radiolucent band adjacent to zone of provisonal calcification due to suppressed osteoblastic activity with normal mineralisation • Trabecular bone mass is decreased in zone of primary and secondary spongiosa. Scorbutic zone (Trümmerfeld’s zone).
  • 8. JSS Medical College, Mysuru PELKAN’S SPUR • Zone of provisional calcification extends beyond the margins of the metaphysis resulting in periosteal elevation and marginal spur formation • These bony protuberances occur at the metaphyseal margins and extend at right angles away from the shaft axis.
  • 9. JSS Medical College, Mysuru CORNER (ANGLE) SIGN • Irregularity of the metaphyseal margins secondary to infractions of the epiphyseal-metaphyseal junction
  • 10. JSS Medical College, Mysuru SUBPERIOSTEAL HEMORRAGES • Due to increased capillary permeability • Seen in ends of long bones(femur,tibia, humerus) • May cause periosteal elevation and new bone formation
  • 11. JSS Medical College, Mysuru Thank You For more Radiology Education visit www.jssmcradiology.com