During the 10 years of Hackteria.org we have established a global network and online knowledge base enabling practioners from diverse backgrounds to experiment with life science methodologies, from laboratory biology and genetics to environmental monitoring or fermentation. We have explored methods of collaboration, established in the early interenet culture, such as hackathons or docusprints as offline physical face-to-face production sessions, aswell as online tools for co-writing text-based instructions and lab notes. In this talk, I will give an overview of how our DIWO (Do-It-With-Others) method has lead to highly innovative projects, low-cost laboratory infrastructures, playful and critical prototypes, new workshop methods embracing a radically transdisciplinary approach to bridge the arts and the sciences.