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The University of Utah Center for Clinical and Translational Science (CCTS)

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The University of Utah Center for Clinical and Translational Science (CCTS)

  1. 1. The University of Utah CenterThe University of Utah Center for Clinical and Translationalfor Clinical and Translational Science (CCTS)Science (CCTS) Carrie L. Byington, MD HA and Edna Benning Presidential Professor of Pediatrics Associate Vice President for Faculty and Academic Affairs Co-Director CCTS April 30, 2014 Accelerating Discoveries Toward Better HealthAccelerating Discoveries Toward Better Health
  2. 2. What is the University of Utah CCTS? • The CCTS is designed to provide an infrastructure and home for Clinical and Translational Research in Utah and the Intermountain Region – Funded by the NIH/NCRR CTSA Consortium – Funded 2008-2013 – Renewed 2013-2018 – http://www.ccts.utah.edu/
  3. 3. 62 Institutions in 31 States and Washington, DC62 Institutions in 31 States and Washington, DC
  4. 4. CTSA Goals • Maximize investments in Core Resources to increase efficiency of translational research • Engage Community Partners • Train and Sustain Future Leaders
  5. 5. What is Translational Research?
  6. 6. University of Utah CCTS Partners • University of Utah (UU) – School of Medicine – Colleges of Engineering, Health, Nursing, and Pharmacy • Intermountain Healthcare (Intermountain) • The Salt Lake Veteran’s Affairs Health Care System (VA) • Utah Department of Health (UDOH)
  7. 7. Governance • Principal Investigators: – Donald McClain, MD, PhD (Medicine; T1) – Carrie L. Byington, MD (Pediatrics; T2-3) – Associate Directors include • Michael Varner, MD Department of Obstetrics – Associate Director Intermountain • Matthew Samore, MD – Associate Director VA • Wu Xu, PhD – Associate Director UDOH
  8. 8. Governance • Executive Steering Committee (N=20) – Directors of all Cores – Senior leadership of UU, VA, Intermountain, UDOH • Internal Advisory Committee (N=16) – Provide first review for proposals such as KL2 and pilot projects • External Advisory Committee: – U Colorado, Harvard University, Scripps University, Tufts University • Oversight by NIH/NCATS
  9. 9. CCTS Service Cores • Biomedical Informatics-Julio Facelli, PhD • Clinical Services-J. Robinson Singleton, MD • Community Outreach and Collaboration-Louisa Stark, PhD and Steven Alder, PhD • Patient Centered Research Methods-Lucy Savitz, PhD. MBA • Recruitment, Retention, and Safety-Jeffrey Botkin, MD • Research Education, Training, and Career Development- Carol Sweeney, PhD • Study Design and Biostatistics-Tom Greene, PhD • Translational Technology Resources-Felipe Lorenzo, MD, PhD
  10. 10. Biomedical Informatics Core • REDCap-Research Electronic Data Capture • FURTHeR – Capture and query data from the EDW • UDOH – All Patient Claims database – IBIS – BioSample Tracker
  11. 11. Clinical Services Core • A setting for controlled clinical investigation • Located on 5th floor University Hospital • Research Nursing, Infusion, Dietary, Laboratory, and Radiology services
  12. 12. Facilities of the CSC • The CSC is located on the 5th floor of the University of Utah Hospital – Patient registration and waiting area – 5 outpatient exam rooms – 3 procedure suites with recovery area – 7 fully equipped hospital rooms – Nursing station – Dietary kitchen – Bone Density and Body Composition Suite
  13. 13. Community Outreach and Collaboration • Consultation services • Community Faces of Utah – Best of Africa – Calvary Baptist Church – Hispanic Health Care Task Force – Urban Indian Center of Salt Lake – National Tongan American Society
  14. 14. Patient Centered Research Methods • Advancing Methods in PCOR – Pragmatic Trials – Comparative Effectiveness – Mixed-Methods Research • Certificate Program in CER/PCOR – 15 credit hours – Courses taught through MSCI
  15. 15. Recruitment Retention and Safety • Research Participant Advocate – Assistance with IRB • Foreign Language Translation
  16. 16. Research Education, Training, and Career Development • Masters of Science in Clinical Investigation (MSCI) – Track 1 • Inherited basis of human disease • Mechanistic laboratory based clinical research – Track 2 • Epidemiology • Health Services • Bedside to Community Translation • Comparative Effectiveness Research • Patient Centered Outcomes Research Methods
  17. 17. Career Development • TL1 Training Program in Human Genome Analysis (application due May 15, 2014) – Post-Doctoral MD or PhD trainees – Post-Doctoral stipend and travel • KL2 Career Development Program – Translational Research – Personalized Healthcare – Supports junior faculty for 2 years including • 75% FTE salary and benefits • Research support, travel and mentor support
  18. 18. Study Design and Biostatistics • 37 MS and PhD Statisticians and Epidemiologists • Expertise – Cancer – Woman and Child Health – Statistical Genetics and Genomics – Survey Methods – Qualitative analysis
  19. 19. New Translational Technologies • DNA isolation and EBV Transformation • RIA/EIA cytokine measurement • Microarray at HCI • 3D Facial Morphometry • Metabolomics with mass spectroscopy • Mitochondrial function • Metabolic phenotyping
  20. 20. New Cores and Services • Health Economics-Design and Analysis • Systematic Knowledge Review • Study Section
  21. 21. Carrie.byington@hsc.utah.edu

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