NSAIDs such as aspirin and ibuprofen work by blocking the synthesis of prostaglandins, lipids involved in inflammation. They do this by inhibiting cyclooxygenase enzymes. This lipid-blocking mechanism explains their anti-inflammatory effects but also causes stomach pain as prostaglandins protect the stomach lining. The document then asks a series of questions about the function of different lipoproteins like HDL, LDL, VLDL, and chylomicrons that transport lipids through the bloodstream. It also asks about the purpose of protein and phospholipid components of lipoproteins.

1. please answer the sections of the page
n-steroidal Anti-Inflam work by block heti-Infammatory Drugs (NSAIDs) such as aspirin,
ibuprofen, and naproxen, blockin the synthesis of a particular type of lipid, as described in class.
Briefy nov they work, and why they also cause stomach pain for many people. The structure at
the right represents a lipoprotein, as shown in class. a. What is the function of high-density
lipoproteins (HDLs)? (2 points) b. What is the function of LDLs? (2 points) c. What is the
function of VLDLs? (2 points) d. What is the function of chylomicrons? (2 points) c. What is the
function of the protein components in a lipoprotein? (2 points) d. What is the purpose of the
phosphoglycerides in a lipoprotein? (2 points) g. If someone has familial hypercholesterolemia,
which type of phospholipid will be found in the blood stream in very high levels? Explain why it
builds up to such high levels in the blood stream. (2 points)
Solution
a) HDL is reaponsible for the transportation of cholesterol to the liver from cells and tissue.It
helps in the removal of extra cholesterol from the cells as well as from the blood vessels.
b) LDL works opposite to HDL as it transport cholesterol to the cells which helps in the
synthesis of steroid hormones and membranes.
c) It helps in the tranport of lipids in the internal body.It also transport intracellular messenger
which are hydrophobic in nature.
d) It helps in the transportation of lipids which are absorbed by the intestine to adipose, cardiac
and skeletal muscle.These lipids are then acted upon by lipase due to which fatty acids are
released and absorb by the tissue.