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ICH Guideline 2010 :
         Enigma
“One would think that we would know exactly what to do by now,
          and we should have the pathophysiology well in hand.
                  Unfortunately, we are left with only guidelines,
                                which essentially are admissions
                               that we don’t know what to do.”
                                              -- Roberts JR, 2011
The issues


                                       Glucose &
                                      temperature

                            Seizure
Neuroimaging
                            control


                   ED
               management


 Prehospital
management
..and the most confusing issues

                                BP
                            management




                      ICP
                   monitoring




                                 Surgery &
                                Clot removal
Should we reduce BP in acute ICH?
                        No,               Yes,
                  increased BP is   increased BP is
                     necessary          harmful




Is there evidence of                            Hematoma expansion
perihematoma ischemia??                         is a reality
Best timing for Clot Removal
              Recommendation:
              < 7 hours, may be useful
              not significant

(too) Early     • Rebleeding
 12 hour        • Not significant
 24 hour        • Not significant
 48 hour        • Not significant
 96 hour        • Not significant


 No Surgery ?
ICP monitor in Stroke, not useful?

  For most patients with ICH, the           Ventricular drainage as treatment for
usefulness of surgery is uncertain.           hydrocephalus is “reasonable”..



                         GCS 8 or lower, transtentorial
                          herniation, significant IVH /
                         hydrocephalus  “might be
                              considered” for ICP
                          monitoring and treatment.

                                           ..no clear evidence at present indicates
                                          that ultra-early removal of supratentorial
MAP >130 + increase ICP  CPP 60            ICH improves functional out- come or
                                          mortality rate. Very early craniotomy may
                                                          be harmful..
Conclusion :




               New “eye”

               Compare
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ICH Guideline 2010: Enigma of Management

  • 2. “One would think that we would know exactly what to do by now, and we should have the pathophysiology well in hand. Unfortunately, we are left with only guidelines, which essentially are admissions that we don’t know what to do.” -- Roberts JR, 2011
  • 3. The issues Glucose & temperature Seizure Neuroimaging control ED management Prehospital management
  • 4. ..and the most confusing issues BP management ICP monitoring Surgery & Clot removal
  • 5. Should we reduce BP in acute ICH? No, Yes, increased BP is increased BP is necessary harmful Is there evidence of Hematoma expansion perihematoma ischemia?? is a reality
  • 6. Best timing for Clot Removal Recommendation: < 7 hours, may be useful not significant (too) Early • Rebleeding 12 hour • Not significant 24 hour • Not significant 48 hour • Not significant 96 hour • Not significant No Surgery ?
  • 7. ICP monitor in Stroke, not useful? For most patients with ICH, the Ventricular drainage as treatment for usefulness of surgery is uncertain. hydrocephalus is “reasonable”.. GCS 8 or lower, transtentorial herniation, significant IVH / hydrocephalus  “might be considered” for ICP monitoring and treatment. ..no clear evidence at present indicates that ultra-early removal of supratentorial MAP >130 + increase ICP  CPP 60 ICH improves functional out- come or mortality rate. Very early craniotomy may be harmful..
  • 8. Conclusion : New “eye” Compare (other guidelines & literature) Keep searching