1. Building on Our Industry
Leadership
The world leader in serving science
Marc N. Casper
Chief Operating Officer
Ian D. Jardine, PhD
Vice President, Global R&D
Pittcon 2009 Press Conference
March 9, 2009

2. The World Leader in Serving Science
We are the leading provider of analytical instruments,
equipment, reagents and consumables, software and services
for research, analysis, discovery and diagnostics.
Leading Brands
Size and Scale Unmatched Capabilities
Complete portfolio
$10.5 billion in revenues
World-class technologies
34,000+ employees in 40 countries
Commercial and service strength
Serving 350,000 customers
in 150 countries
Fortune 300 company
2

3. A Mission We are Proud of
Safer
Healthier Cleaner
We enable our customers to make the world
healthier, cleaner and safer
3

4. Our Strengths
Global industry leadership Ability to continuously invest
in growth opportunities
Key competitive • Developing innovative products
advantages
• Invested $250 million in R&D in 2008
Broad portfolio
• • Strengthening commercial capabilities
Diverse customer base
• • Extending our channel reach
Global reach
• • Expanding in growing markets
Strong balance sheet
• • Focus on China and India
Excellent track record
of financial performance
A partner you can count on
4

5. A Compelling Value Proposition
Targeted
Innovation
We deliver unmatched scientific
productivity through our innovative
technologies, services and systems.
Scientific
Productivity
Extended
Business
Partner
5

6. Thermo Scientific: New Products for Today’s Demands
Better analytical Greater efficiency
Voice of Customer
performance and productivity
Speed and sensitivity Integrated workflows
Precise quantitation Data management
Ease of use Broad applications
Advanced technologies
Laboratory
for non-experts
Industrial and field
Sustainability
Energy efficiency
Reduced solvent usage
Differentiated in performance and productivity
6

7. Fisher Scientific: One Source, Infinite Solutions
Providing customers with a growing portfolio
of convenient sourcing and service options
7

8. Helping our Customers Achieve their Goals
Pharmaceutical Customer
Targeted Laboratory Business
Innovation Productivity Partner
Equipment standardization Consolidated ordering
Scientific collaboration
Methods development Standard operating E-commerce platform
procedures and validation
Application-based Third-party sourcing
workflows Global logistics network Outsourced services
Data management and asset management
8

9. Expanding our Capabilities with Strategic Acquisitions
Equipment
Instrumentation
Chemito Technologies: FiberLite: Carbon fiber centrifuge rotors
Routine analytical instruments
Consumables and Reagents Customer Channels
Open Biosystems: RNAi Hucoa Erloss, Afora, Bonsai:
Affinity Bioreagents: Antibodies Extends European channels
9

10. The World Leader in Serving Science
10

11. Pittcon 2009: New Products for Key Applications
Sample Analysis
Sample Preparation
Data Interpretation
11

12. Pittcon 2009: New Products for Sample Preparation
Sample Analysis
Sample Preparation
Data Interpretation
12

13. Pittcon 2009: New Products for Sample Preparation
Hamilton
Distinction II
Green Lab
Meters
Furniture
Hamilton Infinity
Fume Hood
Electrodes
siRNA, shRNA, miRNA
Bioreagents
Protein Catalogs
13

14. Pittcon 2009: New Products for Sample Analysis
Sample Analysis
Sample Preparation
Data Interpretation
14

15. New Thermo Scientific Products for Sample Analysis
Industrial &
Drug Discovery Petroleum &
Environmental &
Basic
Product Testing
& Development Chemical
Food Screening
Research
TSQ Vantage™
LCMS
Access Max™
Transcend TLX™
Accela Exactive™ LCMS
™
NanoDrop
2000/2000c
UV/Vis
Titan 4000™
Niton XRF GOLDD™ NSX Analyzer
R
Arena™
Chemistry Analyzer
A range of innovations, from research to routine testing
15

16. Revolutionary New Micro UV-Vis Capability
Basic Research
Customer Needs: Thermo Scientific NanoDrop
Quick, easy, accurate UV-Vis analysis
Low or no sample prep, reduced solvents
More sensitivity
Our Response:
Unique “all-in-one” Spectrophotometer
Ideal for DNA, RNA, proteins, cell cultures
Patent-pending combination of micro-volume
pedestal and built-in cuvette capability
200X concentration vs. conventional specs
Broad wavelength range
Kinetics capability
Dramatic advances in UV-Vis performance
16

17. Leading-Edge Performance
Thermo Scientific
NanoDrop 2000c
Key Specifications
Broad: concentration range (ng/µl) 0.4 – 15,000 ng/ul (dsDNA)
Broad: wavelength range (nm) 190 - 840
Accurate: absorbance accuracy and precision 2% and .002
Fast: measurement time (secs) <5 (pedestal)
Fast: measurement time (secs) <3 (cuvette)
Versatile: number of path lengths 7
Advanced: custom methods capability yes
Small: minimum sample size (µl) 0.5
Compact: footprint (cm) 14 x 20
17

18. Intuitive, Clear, Easy-to-Use Software
18

19. Highest Triple Quad Sensitivity
Drug Discovery & Development
Customer Needs: Thermo Scientific TSQ Vantage Mass Spec
Greater sensitivity (S/N) for
Hesi II probe
ultralow-level quantitation
Precision and reproducibility
Multiple analytes per run
New
Our Response:
sweep
10X more sensitivity than cap
any other triple quad
1,000 SRMs per second and
3,000 timed SRMs per LC run
Full peptide, protein quantitation
TSQ series 2.0.0 software
Patented S-lens
Unmatched signal-to-noise performance exceeds
customer expectations
19

20. TSQ Vantage Beats Existing Systems
Sample Name: quot;Std 0.01quot; Sample ID: quot;quot; File: quot;08305rlc39a PPT Evap 8Mar08 4.wiffquot;
Peak Name: quot;Dextromethorphan-d3quot; Mass(es): quot;275.2/171.2 amuquot;
RT: 0.98 - 3.96
Comment: quot;quot; Annotation: quot;quot;
Sample Index: 31
NL: 1.35E4
RT: 3.04
Sample Type: Standard 2.68
100
Concentration: 0.0100
TIC F: + c ESI
Calculated Conc: 0.0109 740
Acq. Date: 3/9/2008
SRMms2 275.180
Acq. Time: 2:11:48 PM
720
95 [171.049-171.051]
Modified: No
Proc. Algorithm: IntelliQuan - MQII 700
MS ICIS
Noise Percentage: 93
Base. Sub. Window: 1.00 min
680
competitor 90 tt-test_mix_124
Peak-Split. Factor: 2
Report Largest Peak: No
660
Min. Peak Height: 200.00 cps
Min. Peak Width: 4.00 sec
Smoothing Width: 3 points
85
640
RT Window: 30.0 sec
Expected RT: 2.72 min
620
Use Relative RT: No
80
Int. Type: Base To Base 600
Retention Time: 2.69 min
Area: 1892.34 counts
580
Height: 5.72e+002 cps
75
Start Time: 2.63 min
Dextromethorphan-d3
560
End Time: 2.74 min
540
70
In Rat Plasma
520
500
65
(LLOQ at 0.01 ng/mL)
TSQ Vantage
480
460
60
Relative Abundance
440
420
55
>10X LOQ
400
In t e n s it y , c p s
50
380
360
better than
45
340 2.59
3.23
320
40
competitor’s
300
2.82
280 3.07
2.78
35
260 3.41
best efforts
2.85 3.13
2.95 3.58
240 2.40 3.34
30
220
200
25
180
160
20
140
15
120
100
10
80
60
5
40
20
0
0
1.0 1.5 2.0 2.5 3.0 3.5
1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 3.0 3.1 3.2 3.3 3.4 3.5 3.6
Time, min
Time (min)
Unsurpassed triple quad performance
20

21. High Performance for Routine Applications
Environmental & Food Screening
Customer Needs:
Thermo Scientific Workflow Solution
Advanced screening for routine
applications
Higher sensitivity and throughput
Streamlined method development
Our Response:
Simultaneous quantitation and
structural confirmation
Fast +/- switching for high-
speed multi-component trace
analysis
3000 timed SRMs per LC run
New TraceFinder software
Quantum
TraceFinder™ Software
Accela UHPLC Access MAX™
™
The value choice for routine food safety,
pharma, environmental and clinical applications
21

22. Accela-Access Max Performance in Pesticide Screening
Tricyclazole
Carbaryl
Carbofuran
Diuron
Siduron
Daimuron
Carpropamine
Time (minutes)
Complex multi-residue pesticide analysis (10 ppt) in <3 minutes
22

23. End-to-End Workflow for Multiplexing LC/MS/MS
Drug Discovery & Development
Customer Needs:
Thermo Scientific Workflow Solution
In-line sample extraction
End-to-end workflow analysis
Our Response:
Doubles sample analysis
throughput
Increases detection limits
New high performance ultralow
dead volume LC pumps
Fully integrated software for
multiplexed LC-MS
™
Accela UHPLC™ TSQ Vantage
Transcend TLX™
High-throughput benchmark for clinical and drug analysis
23

24. A Revolution in LC-MS
Environmental & Food Screening
Customer Needs:
Thermo Scientific Exactive
Cost effective target ID and
compound identification
Higher throughput analysis with
advanced mass accuracy
Easy-to-use workflow enabler and
productivity platform
Our Response:
Full scan MS with HCD scanning
Walk-up compound identification
• Pesticides, metabolites, tox screening
New quantitation capabilities
Accela UHPLC™
Powerful Pathfinder™ software
Speed, spectra, ultrahigh resolution, superb accurate mass,
and precise quantitation all in an affordable bench-top system
24

25. The Value of Reproducible High Mass Accuracy
Total of about 110 pesticides Component Elemental Composition [M+H] Error [ppm]
(each ~ 250 ug/L) Propoxur C11H15NO3 210.1125 1.10
in very complex horse feed matrix Chlortoluron C10H13ClN2O 213.0789 1.20
Metribuzin C8H14N4OS 215.0961 2.00
Atrazine C8H14ClN5 216.1011 2.50
Diuron C9H10Cl2N2O 233.0243 2.00
Carbetamide C12H16N2O3 237.1234 1.20
Pirimicarb C11H18N4O2 239.1503 6.50
Clomazone C12H14ClNO2 240.0786 0.10
Cyanazine C9H13ClN6 241.0963 0.90
Linuron C9H10Cl2N2O2 249.0192 1.20
Thiacloprid C10H9ClN4S 253.0309 0.70
Triadimefon C14H16ClN3O2 294.1004 0.30
Paclobutrazol C15H20ClN3O 294.1368 1.40
Fenthion-
sulfoxide
Fast chromatography (<15mins) C10H15O4PS2 295.0222 2.00
Triadimenol
Exactive running at 15,000 resolution C14H18ClN3O2 296.1161 0.20
Imazalil C14H14Cl2N2O 297.0556 1.70
Spiroxamine C18H35NO2 298.2741 1.20
All molecular weight masses within 2.5 ppm except…
25

26. The Value of Reproducible High Mass Accuracy
Total of about 110 pesticides Component Elemental Composition [M+H] Error [ppm]
(each ~ 250 ug/L) Propoxur C11H15NO3 210.1125 1.10
in very complex horse feed matrix Chlortoluron C10H13ClN2O 213.0789 1.20
Metribuzin C8H14N4OS 215.0961 2.00
Atrazine C8H14ClN5 216.1011 2.50
Diuron C9H10Cl2N2O 233.0243 2.00
Carbetamide C12H16N2O3 237.1234 1.20
6.50
Pirimicarb C11H18N4O2 239.1503 6.50
Clomazone C12H14ClNO2 240.0786 0.10
Pirimicarb
Cyanazine C9H13ClN6 241.0963 0.90
Linuron C9H10Cl2N2O2 249.0192 1.20
Thiacloprid C10H9ClN4S 253.0309 0.70
Triadimefon C14H16ClN3O2 294.1004 0.30
Paclobutrazol C15H20ClN3O 294.1368 1.40
Fenthion-
Unusually high error of 6.5 ppm sulfoxide C10H15O4PS2 295.0222 2.00
Re-analyze @ higher resolution of 80,000 Triadimenol C14H18ClN3O2 296.1161 0.20
Imazalil C14H14Cl2N2O 297.0556 1.70
Spiroxamine C18H35NO2 298.2741 1.20
Only Orbitrap technology allows this level of confidence
26

27. The world leader in serving science

28. The Value of High Mass Accuracy and
Ultrahigh Resolution
The Case for Exactive
100%
A mixture of >100 pesticides,
Detected compounds ppm
10
250
mycotoxins and veterinary 45%
drugs at different concentration
99%
levels in horse feed matrix
50
analyzed at two resolution 32%
settings utilizing full scan
accurate mass measurements 93%
250
10
(+/- 2ppm)
11%
0 20 40 60 80 100
100k
% Detected
10K
10K resolution can’t detect known chemicals
The power of 100K resolution
Vastly superior analytical results with Orbitrap performance
28

29. The Value of High Mass Accuracy and
Ultrahigh Resolution – Quantitation
Concentration
ranging from
0.2 ppb to 500
ppb
Lowest
Data point
Dextrorphan
profile
with internal
+/- 5 ppm
standard
0.5 - 500 pg
on-column
29

30. New Pathfinder Screening Software for Exactive
Drug Discovery & Development
Thermo Scientific Pathfinder
Enabling the right workflow for
the right user Experienced user
Walk-up user
Developed methods
significantly streamline
analysis
Links into other software:
• Thermo Scientific ToxID
• Thermo Scientific Xcalibur
Reports
Pathfinder leverages full instrument capabilities
30

31. Orbitrap Technology for Routine Screening Applications
Thermo Scientific Exactive
Exactive™ will displace TOFs and QTOFs!
31

32. Superior Total NSX Analysis in a Small Footprint
Petroleum & Chemical
Customer Needs:
Thermo Scientific
Easy sample introduction TITAN 4000 NSX Analyzer
Simple operation
Increased analysis speed and sensitivity
Our Response:
Total nitrogen and total sulfur (TN/TS)
analysis in <2 minutes
Up to 60% reduction in bench space
New nebulizing injection technique with
high efficiency folded combustion tube
NSX visual software EST Analytical
Booth 1816
New capability for QC with increased productivity and lower
operating costs for petrochemical and refinery industries
32

33. Next-Generation Portable XRF Elemental Analysis
Industrial & Product Testing
Customer Needs: Thermo Scientific Niton XL3t GOLDD
Speed and sensitivity
Portable and field rugged
Identify multiple elements
Other Thermo Scientific
Real time data and simple
Technology Niton XL3t GOLDD
software interface
Samples
Our Response:
10x faster than conventional
detectors
3x more precise than traditional
silicon drift detectors Smaller Area
Detector Large Area
Proprietary GOLDDTM Large Area Detector
Drift Detector
Light element detection without
helium or vacuum purging
Breakthrough lab-quality performance in a handheld detector
33

34. “Clinical Chemistry” Analyzer for Non-clinical Labs
Industrial & Product Testing
Customer Needs:
Thermo Scientific Arena Analyzer
Easy and rapid automated methods
Walk-away analysis
Single system for multiple applications
Our Response:
Fast and efficient analysis in an advanced
all-in-one system
• Colorimetric and enzymatic applications
• 45 reagent positions
• Wavelength range 340 to 880 nm
• Automatic barcode ID
Accurate QC and analysis for pharma,
agricultural, food
• Example: Asparagine + glucose = potential
acrylamide formation
Sample throughput up to 600 tests per hour
34

35. Pittcon 2009: New Data Interpretation Solutions
Sample Analysis
Sample Preparation
Data Interpretation
35

36. Pittcon 2009: New Data Interpretation Solutions
Pathfinder TraceFinder
Connects
Enterprise
Insights
OMNIC Specta on Raman
36

37. Pittcon 2009: New Data Interpretation Solutions
0001110101010010010110101001010100101010100011010010101011010101010101010101010101010110101010101010
Maximize customer ROI from previous software investments
37

38. A Mission We are Proud of
Safer
Healthier Cleaner
Environmental &
Food Safety
Pharma & Biotech Industrial
Screening
Quantitation Portability
Confirmation
Speed Speed
Throughput
Selectivity Sensitivity
Ease of use
Data management Robustness
We enable our customers to make the world
healthier, cleaner and safer
38

39. See it All!
Information
Mass Spectrometry Chromatography
Molecular Spectroscopy and Chromatography Consumables
Fisherbrand and Fisher Scientific products Nucleus
LIMS, COS and
Elemental Analysis Chemicals
Spectroscopy
Software
HandheldXRF Analyzers
Mass Spectrometry
and Chromatography
Water Purification Life Science
Discrete Photometric Blue Crew
Analyzers
Sample
Particle Technology Chromatography Preparation
Laboratory Furniture
and Fume Hoods
Elemental Analysis
UV-Visible
Fisherbrand and
Spectroscopy
and Fluorescence Micro/Analytical
Water Analysis Instruments Fisher Scientific products Technologies
TRAM
39

40. Your Passport to Scientific Innovation
Visit Thermo Scientific Booth 1432
Information
Mass Spectrometry Chromatography
Molecular Spectroscopy and Chromatography Consumables
LIMS, COS and
Elemental Analysis
Spectroscopy
Software
HandheldXRF Analyzers
Mass Spectrometry
and Chromatography
Water Purification
Discrete Photometric
Analyzers
Particle Technology
Laboratory Furniture
and Fume Hoods
Elemental Analysis
UV-Visible
and Fluorescence
Water Analysis Instruments
40