168. Normally, a single transmembrane protein with EXC domain, binds to GF, dimerizes, leads to autophosphorylation and activation
169. In mutated form, muscle tropomysoin dimerizes transmembrane and cytoplasmic domains of the receptor b/c each polypeptide that forms muscle tropomysin binds to the transmembrane or is expressed as the link to a transmembrane domain and cytoplasmic domain.
170. Linked as if dimerized by receptor and then autophosphorylated and activated all the time
171. This Trk oncoprotein is the result of this DNA rearrangement event where tropomysoin, which is normally an actin binding protein in muscle, is now linked up with GF receptor, leading to unrestricted cell growth