Ab Formation 2001

Hallmarks of the Immune Response ,[object Object],[object Object],[object Object]

Fate of the Immunogen ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Immune Elimination Phase Days after Injection 2 4 6 8 12 10 Amount of Circulating Ag (%) 25 75 100 50 Equilibrium Phase Catabolic Decay Phase

Kinetics of the Ab Response T-dependent Ag; 1 o Response ,[object Object],[object Object],[object Object],[object Object],Ag D a y s A f t e r I m m u n i z a t i o n A b T i t e r LAG LOG DECLINE PLATEAU

Kinetics of the Ab Response T-dependent Ag; 2 o Response * Specificity ,[object Object],[object Object],[object Object],[object Object],1 o Ag 2 o Ag D a y s A f t e r I m m u n i z a t i o n A b T i t e r

Qualitative Ab Changes during 1 o and 2 o Responses ,[object Object],[object Object],[object Object],1 o Ag 2 o Ag Total Ab IgM Ab IgG Ab D a y s A f t e r I m m u n i z a t i o n A b T i t e r

Qualitative Ab Changes during 1 o and 2 o Responses ,[object Object],[object Object],[object Object],1 o Ag D a y s A f t e r I m m u n i z a t i o n A f f I n I t y 2 o Ag IgG Ab IgM Ab High Dose Low Dose

Qualitative Ab Changes during 1 o and 2 o Responses ,[object Object],[object Object],[object Object],[object Object],10 10 10 8 10 6 10 5 10 9 10 7 High Ag Concentration 10 10 10 8 10 6 10 5 10 9 10 7 Low Ag Concentration Moderate Affinity Ab High Affinity Ab

Qualitative Ab Changes during 1 o and 2 o Responses ,[object Object],[object Object],[object Object],[object Object]

Cellular Events in 1 o Response to T-dependent Ags ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],IgM Memory Cells IgG 1 o Ag

Cellular Events in 2 o Response to T-dependent Ags ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],IgM Memory Cells IgG IgG Memory Cells Memory Pool Virgin B cell

Memory T cells ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Th Memory Cells Th Th Memory Cells Memory Pool Virgin cell

Kinetics of Ab Response to T-independent Ags ,[object Object],[object Object],[object Object],1 o Ag 2 o Ag D a y s A f t e r I m m u n i z a t i o n A b T i t e r IgM Ab

Class Switching ,[object Object],[object Object],[object Object],[object Object],[object Object],  L    3   2  1  4  1  2 P L V D J S S S S S S S S P L S   1  2 S S  Primary Transcript IgM or IgD Primary Transcript IgE RNA DNA DNA DNA Rearrangement L V D J V D J V D J

Membrane vs Secreted Ig ,[object Object],[object Object],[object Object],[object Object],mRNA Primary Transcript H3 H4 M M H3 H4 M M AAAA Membrane Bound H3 H4 AAAA Secreted H3 H4 AAAA H3 H4 M M AAAA DNA Polyadenylation Sites

Ab Formation 2001

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Ab Formation 2001