Ocular Pharmacology

Ocular Pharmacology Introduction of drugs used in Eyes Gyanendra Lamichhane, MD LEI, Bhairahawa

Pharmacodynamics ,[object Object],[object Object],[object Object],[object Object]

Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Drug Delivery in Eyes Topical Periocular Intraocular Systemic drop ointment gel Soft contact lens Subconj. Subtenon Peribulbar Retrobulbar Intracameral Intravitreal oral intravenous Intramuscular

Factors influencing local drug penetration into ocular tissue ,[object Object],[object Object],[object Object],[object Object],[object Object]

Factors influencing local drug penetration into ocular tissue ,[object Object],[object Object],[object Object],[object Object]

TOPICAL ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Ointments ,[object Object],[object Object],[object Object]

Peri-ocular injections ,[object Object],[object Object],[object Object],[object Object]

Periocular ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Intraocular injections ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Sustained-release devices ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Common ocular drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Corticosteroids NSAID

Antibacterials( antibiotics) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antibiotics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antibiotics ,[object Object],[object Object],[object Object]

Antivirals ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],INDICATIONS HZ keratitis Viral uveitis

ANTIFUNGAL ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Mydriatics and cycloplegics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Antiglaucoma drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],systemic bradycardia, Sweating anxiety ocular Irritaion Frontal headache Iris cyst Follicular conjuctivitis

[object Object],Systemic topical acetazoamide Dorzolamide brinzolamide Mechanism of action---- reduce aqueous humour formation Side effect Paresthesiae Frequent urination GI disturbances Hypokalamia

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Anti-inflammatory corticosteroid NSAID

stimulus Phospholipase A 2 Lipoxygenases Leukotrines Steroids NSAIDS

Corticosteroids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Indications ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],NEVER GIVE STEROID IF YOU ARE SUSPECTING ACTIVE INFECTION

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

NORMAL CUPPED DISC ENLARGED CUP

Pre-requisite ,[object Object],[object Object],[object Object],[object Object],[object Object]

NSAIDS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Ocular Lubricants ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Ocular diagnostic drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Ocular diagnostic drugs ,[object Object],[object Object],[object Object]

Local anesthetics ,[object Object],[object Object],[object Object],[object Object]

Complications of topical administration ,[object Object],[object Object],[object Object],[object Object],[object Object]

Amiodarone ,[object Object],[object Object],[object Object]

Digitalis ,[object Object],[object Object]

Chloroquines ,[object Object],[object Object],[object Object],[object Object]

Chorpromazine ,[object Object],[object Object],[object Object],[object Object]

Thioridazine ,[object Object],[object Object]

Ethambutol ,[object Object],[object Object],[object Object]

Ocular Pharmacology

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